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- W2015778757 abstract "Periventricular white matter injury (PWMI) is the leading cause of chronic neurologic injury among survivors of preterm birth. The hallmark of PWMI is hypomyelination and a lack of mature, myelinating oligodendrocytes. Oligodendrocytes undergo a well-characterized lineage progression from neural stem cell to mature oligodendrocyte. Oligodendrocyte precursors have increased susceptibility to oxidative and free radical-mediated injury compared with mature oligodendrocytes as a result of lower levels of antioxidant enzymes and free radical scavengers. In this study, we show that oxidative stress disrupts oligodendrocyte differentiation by two mechanisms. First, oxidizing agents decrease the expression of key genes that promote oligodendrocyte differentiation from neural stem cells and increase the expression of genes known to inhibit differentiation. Second, global histone acetylation persists under conditions of oxidative stress, further contributing to the prevention of oligodendrocyte differentiation. Both of these mechanisms result in the arrest of oligodendrocyte differentiation without an increase in cell death. © 2009 Wiley-Liss, Inc." @default.
- W2015778757 created "2016-06-24" @default.
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- W2015778757 date "2009-11-01" @default.
- W2015778757 modified "2023-10-16" @default.
- W2015778757 title "Oxidative stress disrupts oligodendrocyte maturation" @default.
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- W2015778757 doi "https://doi.org/10.1002/jnr.22139" @default.
- W2015778757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3138415" @default.
- W2015778757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19479983" @default.
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