FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015779621> ?p ?o ?g. }

• W2015779621 endingPage "135" @default.
• W2015779621 startingPage "129" @default.
• W2015779621 abstract "The objective of this study was to ascertain the ability of a single subcutaneous injection of a sustained-release (SR) formulation of moxidectin to protect dogs against challenge inoculation with infective Dirofilaria immitis larvae 364 days after administration. Twenty four purpose-bred adult mixed-breed dogs were grouped into three blocks of eight based on weight and sex. Saline solution (0.9% NaCl) or a moxidectin SR formulation at volumes designed to deliver 0.17 or 0.27 mg moxidectin/kg b.w. was injected subcutaneously on day 0. Throughout the post-treatment period, injection sites of all dogs were periodically examined visually and by palpation. Palpable swellings were characterized as to size, consistency and the presence of associated pain or erythema. On day 364, each dog was inoculated subcutaneously with 50 D. immitis L3. On days 510 and 511, dogs were euthanatized, and their hearts, lungs and thoracic cavities were inspected for the presence of adult heartworms. number, sex and viability of recovered heartworms were determined. The mean number of heartworms recovered from dogs that had received the saline control injection was 35.7. No heartworms were recovered from any dog treated with either 0.17 or 0.27 mg moxidectin/kg b.w. For variable periods of time following treatment, small (1–4 mm diameter), firm, subcutaneous swellings could be palpated at the injection sites of dogs treated with 0.17 or 0.27 mg moxidectin/kg b.w. These swellings contracted progressively and eventually disappeared except for the case of one animal treated with 0.27 mg/kg, in which the swelling persisted for the entire study period. At no time during the study was pain or erythema noted at the injection site of any dog, and no dog exhibited any adverse systemic reaction related to treatment. We conclude that under conditions pertaining in this study, a single subcutaneous injection of a moxidectin SR formulation at dosing rates of either 0.17 or 0.27 mg/kg b.w. can safely protect adult dogs against experimental challenge inoculation with infective heartworm larvae for a period of 12 months." @default.
• W2015779621 created "2016-06-24" @default.
• W2015779621 creator A5003117151 @default.
• W2015779621 creator A5028180388 @default.
• W2015779621 creator A5033479574 @default.
• W2015779621 creator A5044737607 @default.
• W2015779621 creator A5072671523 @default.
• W2015779621 creator A5078721320 @default.
• W2015779621 date "2005-03-01" @default.
• W2015779621 modified "2023-09-25" @default.
• W2015779621 title "Efficacy of an injectable, sustained-release formulation of moxidectin in preventing experimental heartworm infection in mongrel dogs challenged 12 months after administration" @default.
• W2015779621 cites W1969965688 @default.
• W2015779621 cites W1995590338 @default.
• W2015779621 cites W1998289188 @default.
• W2015779621 cites W2013856271 @default.
• W2015779621 cites W2107832593 @default.
• W2015779621 cites W2111459950 @default.
• W2015779621 cites W2111544310 @default.
• W2015779621 cites W2129744147 @default.
• W2015779621 cites W2316048116 @default.
• W2015779621 doi "https://doi.org/10.1016/j.vetpar.2004.11.010" @default.
• W2015779621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15725542" @default.
• W2015779621 hasPublicationYear "2005" @default.
• W2015779621 type Work @default.
• W2015779621 sameAs 2015779621 @default.
• W2015779621 citedByCount "15" @default.
• W2015779621 countsByYear W20157796212013 @default.
• W2015779621 countsByYear W20157796212014 @default.
• W2015779621 countsByYear W20157796212017 @default.
• W2015779621 countsByYear W20157796212019 @default.
• W2015779621 countsByYear W20157796212022 @default.
• W2015779621 crossrefType "journal-article" @default.
• W2015779621 hasAuthorship W2015779621A5003117151 @default.
• W2015779621 hasAuthorship W2015779621A5028180388 @default.
• W2015779621 hasAuthorship W2015779621A5033479574 @default.
• W2015779621 hasAuthorship W2015779621A5044737607 @default.
• W2015779621 hasAuthorship W2015779621A5072671523 @default.
• W2015779621 hasAuthorship W2015779621A5078721320 @default.
• W2015779621 hasConcept C126322002 @default.
• W2015779621 hasConcept C165901193 @default.
• W2015779621 hasConcept C203014093 @default.
• W2015779621 hasConcept C2776186584 @default.
• W2015779621 hasConcept C2776355835 @default.
• W2015779621 hasConcept C2776390293 @default.
• W2015779621 hasConcept C2777397205 @default.
• W2015779621 hasConcept C2777499811 @default.
• W2015779621 hasConcept C42219234 @default.
• W2015779621 hasConcept C42972112 @default.
• W2015779621 hasConcept C71924100 @default.
• W2015779621 hasConcept C86803240 @default.
• W2015779621 hasConceptScore W2015779621C126322002 @default.
• W2015779621 hasConceptScore W2015779621C165901193 @default.
• W2015779621 hasConceptScore W2015779621C203014093 @default.
• W2015779621 hasConceptScore W2015779621C2776186584 @default.
• W2015779621 hasConceptScore W2015779621C2776355835 @default.
• W2015779621 hasConceptScore W2015779621C2776390293 @default.
• W2015779621 hasConceptScore W2015779621C2777397205 @default.
• W2015779621 hasConceptScore W2015779621C2777499811 @default.
• W2015779621 hasConceptScore W2015779621C42219234 @default.
• W2015779621 hasConceptScore W2015779621C42972112 @default.
• W2015779621 hasConceptScore W2015779621C71924100 @default.
• W2015779621 hasConceptScore W2015779621C86803240 @default.
• W2015779621 hasIssue "1-2" @default.
• W2015779621 hasLocation W20157796211 @default.
• W2015779621 hasLocation W20157796212 @default.
• W2015779621 hasOpenAccess W2015779621 @default.
• W2015779621 hasPrimaryLocation W20157796211 @default.
• W2015779621 hasRelatedWork W2001512823 @default.
• W2015779621 hasRelatedWork W2015779621 @default.
• W2015779621 hasRelatedWork W2020578582 @default.
• W2015779621 hasRelatedWork W2096701712 @default.
• W2015779621 hasRelatedWork W2129762128 @default.
• W2015779621 hasRelatedWork W2767643954 @default.
• W2015779621 hasRelatedWork W2767935125 @default.
• W2015779621 hasRelatedWork W2789954415 @default.
• W2015779621 hasRelatedWork W2912891654 @default.
• W2015779621 hasRelatedWork W4284898302 @default.
• W2015779621 hasVolume "128" @default.
• W2015779621 isParatext "false" @default.
• W2015779621 isRetracted "false" @default.
• W2015779621 magId "2015779621" @default.
• W2015779621 workType "article" @default.