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- W2015792302 abstract "We describe the rational design of a novel class of magnetic resonance imaging (MRI) contrast agents with engineered proteins (CAi.CD2, i = 1, 2,..., 9) chelated with gadolinium. The design of protein-based contrast agents involves creating high-coordination Gd3+ binding sites in a stable host protein using amino acid residues and water molecules as metal coordinating ligands. Designed proteins show strong selectivity for Gd3+ over physiological metal ions such as Ca2+, Zn2+, and Mg2+. These agents exhibit a 20-fold increase in longitudinal and transverse relaxation rate values over the conventional small-molecule contrast agents, e.g., Gd−DTPA (diethylene triamine pentaacetic acid), used clinically. Furthermore, they exhibit much stronger contrast enhancement and much longer blood retention time than Gd−DTPA in mice. With good biocompatibility and potential functionalities, these protein contrast agents may be used as molecular imaging probes to target disease markers, thereby extending applications of MRI." @default.
- W2015792302 created "2016-06-24" @default.
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- W2015792302 date "2008-06-25" @default.
- W2015792302 modified "2023-09-23" @default.
- W2015792302 title "Rational Design of Protein-Based MRI Contrast Agents" @default.
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- W2015792302 doi "https://doi.org/10.1021/ja800736h" @default.
- W2015792302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2692035" @default.
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