FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015799969> ?p ?o ?g. }

• W2015799969 endingPage "558" @default.
• W2015799969 startingPage "552" @default.
• W2015799969 abstract "BACKGROUND: In accordance with the Bethesda Guidelines, Auckland's metropolitan hospitals routinely perform immunohistochemistry for mismatch repair proteins on the tumor specimens of all patients with colorectal cancer aged 50 years and younger. When loss of expression is evident, patients are offered genetic counseling and gene mutation analysis. OBJECTIVES: This study aimed to determine the completeness of young patient capture over the first 7 years of routine testing, to find whether patients were referred for genetic testing, and to determine the proportion of patients found to have a mismatch repair gene mutation. DESIGN: This study retrospectively reviewed clinical, pathological, and genetic data. SETTINGS: The study was conducted at 3 public hospitals in Auckland, New Zealand. PATIENTS: All patients aged 50 years and younger treated for colorectal cancer at Auckland's metropolitan hospitals between January 2001 and December 2007 (n = 243) were included. MAIN OUTCOME MEASURES: The loss of expression of mismatch repair proteins by immunohistochemistry, referral for genetic testing, and proportion with mismatch repair gene mutation were the main outcome measures. RESULTS: Two hundred fourteen (88%) eligible patients had immunohistochemical analysis of their tumor and 33 (14%) had loss of expression of one or more mismatch repair proteins. Twenty-six patients were referred for genetic counseling, of whom 22 underwent genetic testing. A mismatch repair gene mutation was identified in 10 patients. LIMITATIONS: Seven patients with loss of expression of mismatch repair proteins by immunohistochemistry were not referred for genetic assessment. CONCLUSIONS: We have identified a mismatch repair gene mutation diagnostic of hereditary nonpolyposis colorectal cancer in 5% of all patients with colorectal cancer who were aged 50 years and younger. Routine immunohistochemical prescreening has important clinical benefit for these patients and their relatives." @default.
• W2015799969 created "2016-06-24" @default.
• W2015799969 creator A5044191451 @default.
• W2015799969 creator A5065121702 @default.
• W2015799969 creator A5071686356 @default.
• W2015799969 creator A5072633053 @default.
• W2015799969 creator A5076928530 @default.
• W2015799969 creator A5091011830 @default.
• W2015799969 date "2011-05-01" @default.
• W2015799969 modified "2023-10-16" @default.
• W2015799969 title "Immunohistochemistry to Detect Hereditary Nonpolyposis Colorectal Cancer in Young Patients: the 7-Year Auckland Experience" @default.
• W2015799969 cites W1893792948 @default.
• W2015799969 cites W1976786479 @default.
• W2015799969 cites W1990603731 @default.
• W2015799969 cites W1994439601 @default.
• W2015799969 cites W2013795843 @default.
• W2015799969 cites W2019829644 @default.
• W2015799969 cites W2024346369 @default.
• W2015799969 cites W2032131734 @default.
• W2015799969 cites W2038332913 @default.
• W2015799969 cites W2068906373 @default.
• W2015799969 cites W2071508642 @default.
• W2015799969 cites W2093401382 @default.
• W2015799969 cites W2128793721 @default.
• W2015799969 cites W2130830134 @default.
• W2015799969 cites W2145297551 @default.
• W2015799969 cites W2156299764 @default.
• W2015799969 cites W2158153435 @default.
• W2015799969 cites W2162362353 @default.
• W2015799969 cites W4237862172 @default.
• W2015799969 doi "https://doi.org/10.1007/dcr.0b013e31820e3265" @default.
• W2015799969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21471755" @default.
• W2015799969 hasPublicationYear "2011" @default.
• W2015799969 type Work @default.
• W2015799969 sameAs 2015799969 @default.
• W2015799969 citedByCount "16" @default.
• W2015799969 countsByYear W20157999692012 @default.
• W2015799969 countsByYear W20157999692014 @default.
• W2015799969 countsByYear W20157999692015 @default.
• W2015799969 countsByYear W20157999692017 @default.
• W2015799969 countsByYear W20157999692018 @default.
• W2015799969 countsByYear W20157999692019 @default.
• W2015799969 countsByYear W20157999692020 @default.
• W2015799969 countsByYear W20157999692022 @default.
• W2015799969 crossrefType "journal-article" @default.
• W2015799969 hasAuthorship W2015799969A5044191451 @default.
• W2015799969 hasAuthorship W2015799969A5065121702 @default.
• W2015799969 hasAuthorship W2015799969A5071686356 @default.
• W2015799969 hasAuthorship W2015799969A5072633053 @default.
• W2015799969 hasAuthorship W2015799969A5076928530 @default.
• W2015799969 hasAuthorship W2015799969A5091011830 @default.
• W2015799969 hasConcept C104317684 @default.
• W2015799969 hasConcept C121608353 @default.
• W2015799969 hasConcept C126322002 @default.
• W2015799969 hasConcept C142724271 @default.
• W2015799969 hasConcept C143998085 @default.
• W2015799969 hasConcept C180754005 @default.
• W2015799969 hasConcept C204232928 @default.
• W2015799969 hasConcept C207886595 @default.
• W2015799969 hasConcept C2779767149 @default.
• W2015799969 hasConcept C2780140570 @default.
• W2015799969 hasConcept C2780673598 @default.
• W2015799969 hasConcept C2994225774 @default.
• W2015799969 hasConcept C501734568 @default.
• W2015799969 hasConcept C526805850 @default.
• W2015799969 hasConcept C54355233 @default.
• W2015799969 hasConcept C60748783 @default.
• W2015799969 hasConcept C61320498 @default.
• W2015799969 hasConcept C71924100 @default.
• W2015799969 hasConcept C80227256 @default.
• W2015799969 hasConcept C86803240 @default.
• W2015799969 hasConceptScore W2015799969C104317684 @default.
• W2015799969 hasConceptScore W2015799969C121608353 @default.
• W2015799969 hasConceptScore W2015799969C126322002 @default.
• W2015799969 hasConceptScore W2015799969C142724271 @default.
• W2015799969 hasConceptScore W2015799969C143998085 @default.
• W2015799969 hasConceptScore W2015799969C180754005 @default.
• W2015799969 hasConceptScore W2015799969C204232928 @default.
• W2015799969 hasConceptScore W2015799969C207886595 @default.
• W2015799969 hasConceptScore W2015799969C2779767149 @default.
• W2015799969 hasConceptScore W2015799969C2780140570 @default.
• W2015799969 hasConceptScore W2015799969C2780673598 @default.
• W2015799969 hasConceptScore W2015799969C2994225774 @default.
• W2015799969 hasConceptScore W2015799969C501734568 @default.
• W2015799969 hasConceptScore W2015799969C526805850 @default.
• W2015799969 hasConceptScore W2015799969C54355233 @default.
• W2015799969 hasConceptScore W2015799969C60748783 @default.
• W2015799969 hasConceptScore W2015799969C61320498 @default.
• W2015799969 hasConceptScore W2015799969C71924100 @default.
• W2015799969 hasConceptScore W2015799969C80227256 @default.
• W2015799969 hasConceptScore W2015799969C86803240 @default.
• W2015799969 hasIssue "5" @default.
• W2015799969 hasLocation W20157999691 @default.
• W2015799969 hasLocation W20157999692 @default.
• W2015799969 hasOpenAccess W2015799969 @default.
• W2015799969 hasPrimaryLocation W20157999691 @default.
• W2015799969 hasRelatedWork W1446253238 @default.
• W2015799969 hasRelatedWork W1967432094 @default.

• next