FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015804516> ?p ?o ?g. }

• W2015804516 endingPage "955" @default.
• W2015804516 startingPage "947" @default.
• W2015804516 abstract "The present study examines the effect of PAT (peptide analogue of thymulin) in two rat models of inflammatory hyperalgesia induced by either i.pl. (1.25 μg in 50 μl saline) or i.p. (50 μg in 100 μl) injections of endotoxin ET. Pretreatment with PAT (1, 5 or 25 μg in 100 μl saline, i.p.) decreased, in a dose dependent manner, both mechanical hyperalgesia, determined by the paw pressure (PP) test and thermal hyperalgesia determined by the hot plate (HP), the paw immersion (PI) and the tail flick (TF) tests. Compared to the tripeptides K(D)PT and K(D)PV, known to antagonize interleukin (IL)‐1β or IL‐1β and PGE 2 mechanisms, PAT, at lower dosages, exerted stronger anti‐hyperalgesic effects. When compared with the effect of a steroidal (dexamethasone) and a non‐steroidal (indomethacin) anti‐inflammatory drugs (NSAID), PAT demonstrated equal analgesic actions. Pretreatment with PAT, reduced significantly the increased concentration of IL‐1β, IL‐6, TNF‐α and NGF due to i.pl. injection of ET. Injection of i.p. ET produced sickness behaviour characterized by hyperalgesia and fever. Pretreatment with PAT prevented the hyperalgesia and maintained the body temperature within the normal range and was accompanied by a down‐regulation of the levels of pro‐inflammatory cytokines and PGE 2 in the liver. PAT, in all doses used, did not result in any evident changes in the physiological parameters or in the normal behaviour of the rats. The anti‐hyperalgesic and anti‐inflammatory effects of PAT can be attributed, at least partially, to the down‐regulation of pro‐inflammatory mediators. British Journal of Pharmacology (2002) 136 , 947–955. doi: 10.1038/sj.bjp.0704793" @default.
• W2015804516 created "2016-06-24" @default.
• W2015804516 creator A5005945559 @default.
• W2015804516 creator A5049430192 @default.
• W2015804516 creator A5069628546 @default.
• W2015804516 creator A5074941589 @default.
• W2015804516 date "2002-07-01" @default.
• W2015804516 modified "2023-10-18" @default.
• W2015804516 title "Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat" @default.
• W2015804516 cites W13793788 @default.
• W2015804516 cites W185614599 @default.
• W2015804516 cites W1971721309 @default.
• W2015804516 cites W1973380568 @default.
• W2015804516 cites W1974450761 @default.
• W2015804516 cites W1978020711 @default.
• W2015804516 cites W1984632338 @default.
• W2015804516 cites W1989231576 @default.
• W2015804516 cites W1990540517 @default.
• W2015804516 cites W1999382750 @default.
• W2015804516 cites W1999953665 @default.
• W2015804516 cites W2001162433 @default.
• W2015804516 cites W2005211946 @default.
• W2015804516 cites W2008574207 @default.
• W2015804516 cites W2017040808 @default.
• W2015804516 cites W2018317606 @default.
• W2015804516 cites W2025474689 @default.
• W2015804516 cites W2030033188 @default.
• W2015804516 cites W2030368271 @default.
• W2015804516 cites W2043069609 @default.
• W2015804516 cites W2047955328 @default.
• W2015804516 cites W2048734145 @default.
• W2015804516 cites W2054653908 @default.
• W2015804516 cites W2057385802 @default.
• W2015804516 cites W2069718130 @default.
• W2015804516 cites W2076480922 @default.
• W2015804516 cites W2081102214 @default.
• W2015804516 cites W2085356629 @default.
• W2015804516 cites W2087214422 @default.
• W2015804516 cites W2087677773 @default.
• W2015804516 cites W2091414062 @default.
• W2015804516 cites W2097518116 @default.
• W2015804516 cites W2098245604 @default.
• W2015804516 cites W2113683216 @default.
• W2015804516 cites W2120987567 @default.
• W2015804516 cites W2155973578 @default.
• W2015804516 cites W2158686638 @default.
• W2015804516 cites W2281386564 @default.
• W2015804516 doi "https://doi.org/10.1038/sj.bjp.0704793" @default.
• W2015804516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1573422" @default.
• W2015804516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12110619" @default.
• W2015804516 hasPublicationYear "2002" @default.
• W2015804516 type Work @default.
• W2015804516 sameAs 2015804516 @default.
• W2015804516 citedByCount "32" @default.
• W2015804516 countsByYear W20158045162012 @default.
• W2015804516 countsByYear W20158045162013 @default.
• W2015804516 countsByYear W20158045162014 @default.
• W2015804516 countsByYear W20158045162015 @default.
• W2015804516 countsByYear W20158045162016 @default.
• W2015804516 countsByYear W20158045162017 @default.
• W2015804516 countsByYear W20158045162018 @default.
• W2015804516 countsByYear W20158045162019 @default.
• W2015804516 countsByYear W20158045162020 @default.
• W2015804516 countsByYear W20158045162022 @default.
• W2015804516 crossrefType "journal-article" @default.
• W2015804516 hasAuthorship W2015804516A5005945559 @default.
• W2015804516 hasAuthorship W2015804516A5049430192 @default.
• W2015804516 hasAuthorship W2015804516A5069628546 @default.
• W2015804516 hasAuthorship W2015804516A5074941589 @default.
• W2015804516 hasBestOaLocation W20158045162 @default.
• W2015804516 hasConcept C11988809 @default.
• W2015804516 hasConcept C126322002 @default.
• W2015804516 hasConcept C134018914 @default.
• W2015804516 hasConcept C15490471 @default.
• W2015804516 hasConcept C162156334 @default.
• W2015804516 hasConcept C167392928 @default.
• W2015804516 hasConcept C170493617 @default.
• W2015804516 hasConcept C185592680 @default.
• W2015804516 hasConcept C2776914184 @default.
• W2015804516 hasConcept C2777397205 @default.
• W2015804516 hasConcept C2779245659 @default.
• W2015804516 hasConcept C2779281246 @default.
• W2015804516 hasConcept C2780820201 @default.
• W2015804516 hasConcept C55493867 @default.
• W2015804516 hasConcept C71924100 @default.
• W2015804516 hasConcept C98274493 @default.
• W2015804516 hasConceptScore W2015804516C11988809 @default.
• W2015804516 hasConceptScore W2015804516C126322002 @default.
• W2015804516 hasConceptScore W2015804516C134018914 @default.
• W2015804516 hasConceptScore W2015804516C15490471 @default.
• W2015804516 hasConceptScore W2015804516C162156334 @default.
• W2015804516 hasConceptScore W2015804516C167392928 @default.
• W2015804516 hasConceptScore W2015804516C170493617 @default.
• W2015804516 hasConceptScore W2015804516C185592680 @default.
• W2015804516 hasConceptScore W2015804516C2776914184 @default.
• W2015804516 hasConceptScore W2015804516C2777397205 @default.
• W2015804516 hasConceptScore W2015804516C2779245659 @default.
• W2015804516 hasConceptScore W2015804516C2779281246 @default.

• next