FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015810488> ?p ?o ?g. }

• W2015810488 endingPage "132" @default.
• W2015810488 startingPage "127" @default.
• W2015810488 abstract "Recent reports point to a role for the nitric oxide/nitric oxide synthase (NO/NOS) system in implantation. It has been suggested that inducible NOS expressed at peri-implantation would lead to enhanced NO production, which could promote the attachment of the blastocyst. Short-term administration of NO donors during the pre-implantation period reduced the pregnancy rate in a dose-dependent manner. Thus, it is thought that optimal levels of NO are critical for embryo implantation, so regulation of NOS must be crucial. Taking this into consideration, interleukin-10 (IL-10), synthesized and secreted by the embryo, could be modulating NOS during implantation. In this study we have investigated the in vitro effect of IL-10 on NOS in the uterus.To determine the effect of IL-10, slices of uterus from estrogenized mice were pre-incubated for 60 min with different concentrations of IL-10 and NOS activity was measured.IL-10 (50 and 100 ng/ml in vitro) diminished NOS activity. The in vivo administration of lipopolysaccharide (LPS; 8 mg/kg) significantly increased the conversion of arginine into citrulline. This effect was abolished after 60 min of preincubation with IL-10 (100 ng/ml). The stimulatory effect of LPS and estrogen on NOS activity is exerted on the Ca-independent isoform and IL-10 in vitro abolished this increase. We observed that the uterus of pregnant mice on day 5 of gestation synthesized NO. This production was significantly inhibited by preincubation with IL-10 (100 ng/ml).This report demonstrates that IL-10 is capable of inhibiting NO synthesis in estrogenized, LPS-treated and pregnant rat uterus." @default.
• W2015810488 created "2016-06-24" @default.
• W2015810488 creator A5048560817 @default.
• W2015810488 creator A5060018437 @default.
• W2015810488 creator A5064822800 @default.
• W2015810488 creator A5065436861 @default.
• W2015810488 creator A5087227623 @default.
• W2015810488 creator A5090468995 @default.
• W2015810488 date "2004-01-01" @default.
• W2015810488 modified "2023-09-24" @default.
• W2015810488 title "IL-10 Inhibits Nitric Oxide Synthesis in Murine Uterus" @default.
• W2015810488 cites W1488479689 @default.
• W2015810488 cites W1897632974 @default.
• W2015810488 cites W1966420005 @default.
• W2015810488 cites W1966752321 @default.
• W2015810488 cites W1969682877 @default.
• W2015810488 cites W1973958825 @default.
• W2015810488 cites W1974656070 @default.
• W2015810488 cites W1977958742 @default.
• W2015810488 cites W1987095481 @default.
• W2015810488 cites W1988358557 @default.
• W2015810488 cites W1990503476 @default.
• W2015810488 cites W2000364461 @default.
• W2015810488 cites W2000690104 @default.
• W2015810488 cites W2002623546 @default.
• W2015810488 cites W2004489644 @default.
• W2015810488 cites W2010316210 @default.
• W2015810488 cites W2013150268 @default.
• W2015810488 cites W2015260577 @default.
• W2015810488 cites W2025959352 @default.
• W2015810488 cites W2038992843 @default.
• W2015810488 cites W2047750374 @default.
• W2015810488 cites W2063390572 @default.
• W2015810488 cites W2074459416 @default.
• W2015810488 cites W2092800628 @default.
• W2015810488 cites W2099426850 @default.
• W2015810488 cites W2119769457 @default.
• W2015810488 cites W2128635872 @default.
• W2015810488 cites W2131225362 @default.
• W2015810488 cites W2131342021 @default.
• W2015810488 cites W2161221714 @default.
• W2015810488 cites W2170775733 @default.
• W2015810488 cites W2183995663 @default.
• W2015810488 cites W2242363322 @default.
• W2015810488 doi "https://doi.org/10.1159/000075322" @default.
• W2015810488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14758059" @default.
• W2015810488 hasPublicationYear "2004" @default.
• W2015810488 type Work @default.
• W2015810488 sameAs 2015810488 @default.
• W2015810488 citedByCount "9" @default.
• W2015810488 countsByYear W20158104882014 @default.
• W2015810488 countsByYear W20158104882017 @default.
• W2015810488 countsByYear W20158104882020 @default.
• W2015810488 countsByYear W20158104882023 @default.
• W2015810488 crossrefType "journal-article" @default.
• W2015810488 hasAuthorship W2015810488A5048560817 @default.
• W2015810488 hasAuthorship W2015810488A5060018437 @default.
• W2015810488 hasAuthorship W2015810488A5064822800 @default.
• W2015810488 hasAuthorship W2015810488A5065436861 @default.
• W2015810488 hasAuthorship W2015810488A5087227623 @default.
• W2015810488 hasAuthorship W2015810488A5090468995 @default.
• W2015810488 hasConcept C126322002 @default.
• W2015810488 hasConcept C134018914 @default.
• W2015810488 hasConcept C150903083 @default.
• W2015810488 hasConcept C16685009 @default.
• W2015810488 hasConcept C185592680 @default.
• W2015810488 hasConcept C196843134 @default.
• W2015810488 hasConcept C202751555 @default.
• W2015810488 hasConcept C207001950 @default.
• W2015810488 hasConcept C2777164284 @default.
• W2015810488 hasConcept C2777468819 @default.
• W2015810488 hasConcept C2777622882 @default.
• W2015810488 hasConcept C2778177303 @default.
• W2015810488 hasConcept C2778754761 @default.
• W2015810488 hasConcept C2779066055 @default.
• W2015810488 hasConcept C2779129087 @default.
• W2015810488 hasConcept C515207424 @default.
• W2015810488 hasConcept C519581460 @default.
• W2015810488 hasConcept C55493867 @default.
• W2015810488 hasConcept C71924100 @default.
• W2015810488 hasConcept C86803240 @default.
• W2015810488 hasConcept C87073359 @default.
• W2015810488 hasConcept C95444343 @default.
• W2015810488 hasConceptScore W2015810488C126322002 @default.
• W2015810488 hasConceptScore W2015810488C134018914 @default.
• W2015810488 hasConceptScore W2015810488C150903083 @default.
• W2015810488 hasConceptScore W2015810488C16685009 @default.
• W2015810488 hasConceptScore W2015810488C185592680 @default.
• W2015810488 hasConceptScore W2015810488C196843134 @default.
• W2015810488 hasConceptScore W2015810488C202751555 @default.
• W2015810488 hasConceptScore W2015810488C207001950 @default.
• W2015810488 hasConceptScore W2015810488C2777164284 @default.
• W2015810488 hasConceptScore W2015810488C2777468819 @default.
• W2015810488 hasConceptScore W2015810488C2777622882 @default.
• W2015810488 hasConceptScore W2015810488C2778177303 @default.
• W2015810488 hasConceptScore W2015810488C2778754761 @default.
• W2015810488 hasConceptScore W2015810488C2779066055 @default.
• W2015810488 hasConceptScore W2015810488C2779129087 @default.

• next