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- W2015815501 abstract "Somatostatin is known to be a powerful inhibitor of insulin release, but its cellular mechanism has not been established. We studied the effects of somatostatin on insulin release from digitonin-permeabilized rat pancreatic islets. A rise a free Ca 2+ concentration in the medium of 0.1μM to 1-10 μM induced insulin release in a concentration-dependent manner when the islets had been treated with digitonin. Forskolin, an activator of adenylate cyclase, cAMP and 12-O-tetradecanoyl-phorbol-13-acetate, an activator of protein kinase C, augmented insulin release induced by 1 μM Ca 2+" @default.
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- W2015815501 date "1993-01-01" @default.
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- W2015815501 title "<b>EFFECTS OF SOMATOSTATIN ON INSULIN RELEASE FROM DIGITONIN-PERMEABILIZED </b><b>ISLETS </b>" @default.
- W2015815501 doi "https://doi.org/10.2220/biomedres.14.337" @default.
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