FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015816559> ?p ?o ?g. }

• W2015816559 endingPage "203" @default.
• W2015816559 startingPage "195" @default.
• W2015816559 abstract "A new prototype of polymer-derived drug delivery system, the nanoconjugate Polycefin, was tested for its ability to accumulate in tumors based on enhanced permeability and retention (EPR) effect and receptor mediated endocytosis. Polycefin was synthesized for targeted delivery of Morpholino antisense oligonucleotides into certain tumors. It consists of units that are covalently conjugated with poly(β-l-malic acid) (Mw 50,000, Mw/Mn 1.3) highly purified from cultures of myxomycete Physarum polycephalum. The units are active in endosomal uptake, disruption of endosomal membranes, oligonucleotide release in the cytoplasm, and protection against enzymatic degradation in the vascular system. The polymer is biodegradable, non-immunogenic and non-toxic. Polycefin was also coupled with AlexaFluor 680 C2-maleimide dye for in vivo detection. Nude mice received subcutaneous injections of MDA-MB 468 human breast cancer cells into the left posterior mid-dorsum or intracranial injections of human glioma cell line U87MG. Polycefin at concentration of 2.5 mg/kg was injected via the tail vein. In vivo fluorescence tumor imaging was performed at different time points, 0–180 min up to 24 h after the drug injection. The custom-made macro-illumination imaging MISTI system was used to examine the in vivo drug accumulation in animals bearing human breast and brain tumors. In breast tumors the fluorescence signal in large blood vessels and in the tumor increased rapidly until 60 min and remained in the tumor at a level 6 times higher than in non-tumor tissue (180 min) (p < 0.003). In brain tumors drug accumulated selectively in 24 h without any detectable signal in non-tumor areas. The results of live imaging were corroborated histologically by fluorescence microscopic examination of various organs. In addition to tumors, only kidney and liver showed some fluorescent signal." @default.
• W2015816559 created "2016-06-24" @default.
• W2015816559 creator A5001987431 @default.
• W2015816559 creator A5014932947 @default.
• W2015816559 creator A5019253871 @default.
• W2015816559 creator A5021159504 @default.
• W2015816559 creator A5039833815 @default.
• W2015816559 creator A5040529135 @default.
• W2015816559 creator A5069211990 @default.
• W2015816559 creator A5088187575 @default.
• W2015816559 date "2008-01-01" @default.
• W2015816559 modified "2023-10-17" @default.
• W2015816559 title "Nanoconjugate based on polymalic acid for tumor targeting" @default.
• W2015816559 cites W1515660230 @default.
• W2015816559 cites W1601529652 @default.
• W2015816559 cites W1796651434 @default.
• W2015816559 cites W1883170909 @default.
• W2015816559 cites W1966882402 @default.
• W2015816559 cites W1978948741 @default.
• W2015816559 cites W1981290470 @default.
• W2015816559 cites W1982749356 @default.
• W2015816559 cites W1986818072 @default.
• W2015816559 cites W1997771130 @default.
• W2015816559 cites W1998821590 @default.
• W2015816559 cites W2002274759 @default.
• W2015816559 cites W2004616019 @default.
• W2015816559 cites W2007879491 @default.
• W2015816559 cites W2011471236 @default.
• W2015816559 cites W2013749488 @default.
• W2015816559 cites W2015224238 @default.
• W2015816559 cites W2023298707 @default.
• W2015816559 cites W2029250456 @default.
• W2015816559 cites W2030307106 @default.
• W2015816559 cites W2034179078 @default.
• W2015816559 cites W2034464848 @default.
• W2015816559 cites W2044030495 @default.
• W2015816559 cites W2045867269 @default.
• W2015816559 cites W2046851174 @default.
• W2015816559 cites W2047423258 @default.
• W2015816559 cites W2051160517 @default.
• W2015816559 cites W2057343423 @default.
• W2015816559 cites W2061034345 @default.
• W2015816559 cites W2071635215 @default.
• W2015816559 cites W2081666018 @default.
• W2015816559 cites W2083870878 @default.
• W2015816559 cites W2084858608 @default.
• W2015816559 cites W2090514007 @default.
• W2015816559 cites W2091927838 @default.
• W2015816559 cites W2108524724 @default.
• W2015816559 cites W2123175900 @default.
• W2015816559 cites W2134468042 @default.
• W2015816559 cites W2147794687 @default.
• W2015816559 cites W2159556195 @default.
• W2015816559 cites W2166415547 @default.
• W2015816559 doi "https://doi.org/10.1016/j.cbi.2007.01.015" @default.
• W2015816559 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2329596" @default.
• W2015816559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17376417" @default.
• W2015816559 hasPublicationYear "2008" @default.
• W2015816559 type Work @default.
• W2015816559 sameAs 2015816559 @default.
• W2015816559 citedByCount "81" @default.
• W2015816559 countsByYear W20158165592012 @default.
• W2015816559 countsByYear W20158165592013 @default.
• W2015816559 countsByYear W20158165592014 @default.
• W2015816559 countsByYear W20158165592015 @default.
• W2015816559 countsByYear W20158165592016 @default.
• W2015816559 countsByYear W20158165592017 @default.
• W2015816559 countsByYear W20158165592018 @default.
• W2015816559 countsByYear W20158165592019 @default.
• W2015816559 countsByYear W20158165592020 @default.
• W2015816559 countsByYear W20158165592021 @default.
• W2015816559 countsByYear W20158165592022 @default.
• W2015816559 countsByYear W20158165592023 @default.
• W2015816559 crossrefType "journal-article" @default.
• W2015816559 hasAuthorship W2015816559A5001987431 @default.
• W2015816559 hasAuthorship W2015816559A5014932947 @default.
• W2015816559 hasAuthorship W2015816559A5019253871 @default.
• W2015816559 hasAuthorship W2015816559A5021159504 @default.
• W2015816559 hasAuthorship W2015816559A5039833815 @default.
• W2015816559 hasAuthorship W2015816559A5040529135 @default.
• W2015816559 hasAuthorship W2015816559A5069211990 @default.
• W2015816559 hasAuthorship W2015816559A5088187575 @default.
• W2015816559 hasBestOaLocation W20158165592 @default.
• W2015816559 hasConcept C150903083 @default.
• W2015816559 hasConcept C153911025 @default.
• W2015816559 hasConcept C178790620 @default.
• W2015816559 hasConcept C185592680 @default.
• W2015816559 hasConcept C207001950 @default.
• W2015816559 hasConcept C2779820397 @default.
• W2015816559 hasConcept C502942594 @default.
• W2015816559 hasConcept C55493867 @default.
• W2015816559 hasConcept C86803240 @default.
• W2015816559 hasConceptScore W2015816559C150903083 @default.
• W2015816559 hasConceptScore W2015816559C153911025 @default.
• W2015816559 hasConceptScore W2015816559C178790620 @default.
• W2015816559 hasConceptScore W2015816559C185592680 @default.
• W2015816559 hasConceptScore W2015816559C207001950 @default.
• W2015816559 hasConceptScore W2015816559C2779820397 @default.

• next