FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015840315> ?p ?o ?g. }

• W2015840315 endingPage "87" @default.
• W2015840315 startingPage "83" @default.
• W2015840315 abstract "Abstract Many lineage-specific developmental regulator genes are transcriptionally primed in embryonic stem (ES) cells; RNA PolII is bound at their promoters but is prevented from productive elongation by the activity of polycomb repressive complexes (PRC) 1 and 2. This epigenetically poised state is thought to enable ES cells to rapidly execute multiple differentiation programs and is recognized by a simultaneous enrichment for trimethylation of lysine 4 and trimethylation of lysine 27 of histone H3 (bivalent chromatin) across promoter regions. Here we show that the chromatin profile of this important cohort of genes is progressively modified as ES cells differentiate toward blood-forming precursors. Surprisingly however, neural specifying genes, such as Nkx2-2, Nkx2-9, and Sox1, remain bivalent and primed even in committed hemangioblasts, as conditional deletion of PRC1 results in overt and inappropriate expression of neural genes in hemangioblasts. These data reinforce the importance of PRC1 for normal hematopoietic differentiation and reveal an unexpected epigenetic plasticity of mesoderm-committed hemangioblasts." @default.
• W2015840315 created "2016-06-24" @default.
• W2015840315 creator A5013394786 @default.
• W2015840315 creator A5020380959 @default.
• W2015840315 creator A5021026821 @default.
• W2015840315 creator A5022535195 @default.
• W2015840315 creator A5041171993 @default.
• W2015840315 creator A5042037475 @default.
• W2015840315 creator A5073285869 @default.
• W2015840315 creator A5089481521 @default.
• W2015840315 creator A5089672501 @default.
• W2015840315 date "2011-01-06" @default.
• W2015840315 modified "2023-09-26" @default.
• W2015840315 title "Embryonic stem cell–derived hemangioblasts remain epigenetically plastic and require PRC1 to prevent neural gene expression" @default.
• W2015840315 cites W1967269362 @default.
• W2015840315 cites W1968931043 @default.
• W2015840315 cites W1969015262 @default.
• W2015840315 cites W1969993190 @default.
• W2015840315 cites W1979245454 @default.
• W2015840315 cites W1980274173 @default.
• W2015840315 cites W2000519327 @default.
• W2015840315 cites W2003750107 @default.
• W2015840315 cites W2004196170 @default.
• W2015840315 cites W2013935392 @default.
• W2015840315 cites W2017840637 @default.
• W2015840315 cites W2018235103 @default.
• W2015840315 cites W2030523067 @default.
• W2015840315 cites W2062759109 @default.
• W2015840315 cites W2070015044 @default.
• W2015840315 cites W2070451931 @default.
• W2015840315 cites W2073920108 @default.
• W2015840315 cites W2133938268 @default.
• W2015840315 cites W2134466644 @default.
• W2015840315 cites W2143597290 @default.
• W2015840315 cites W2144141448 @default.
• W2015840315 cites W2157251845 @default.
• W2015840315 cites W2168967248 @default.
• W2015840315 cites W4248042899 @default.
• W2015840315 cites W4298410792 @default.
• W2015840315 doi "https://doi.org/10.1182/blood-2010-03-273128" @default.
• W2015840315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20876850" @default.
• W2015840315 hasPublicationYear "2011" @default.
• W2015840315 type Work @default.
• W2015840315 sameAs 2015840315 @default.
• W2015840315 citedByCount "16" @default.
• W2015840315 countsByYear W20158403152012 @default.
• W2015840315 countsByYear W20158403152013 @default.
• W2015840315 countsByYear W20158403152014 @default.
• W2015840315 countsByYear W20158403152016 @default.
• W2015840315 countsByYear W20158403152017 @default.
• W2015840315 countsByYear W20158403152018 @default.
• W2015840315 countsByYear W20158403152020 @default.
• W2015840315 countsByYear W20158403152023 @default.
• W2015840315 crossrefType "journal-article" @default.
• W2015840315 hasAuthorship W2015840315A5013394786 @default.
• W2015840315 hasAuthorship W2015840315A5020380959 @default.
• W2015840315 hasAuthorship W2015840315A5021026821 @default.
• W2015840315 hasAuthorship W2015840315A5022535195 @default.
• W2015840315 hasAuthorship W2015840315A5041171993 @default.
• W2015840315 hasAuthorship W2015840315A5042037475 @default.
• W2015840315 hasAuthorship W2015840315A5073285869 @default.
• W2015840315 hasAuthorship W2015840315A5089481521 @default.
• W2015840315 hasAuthorship W2015840315A5089672501 @default.
• W2015840315 hasBestOaLocation W20158403151 @default.
• W2015840315 hasConcept C104317684 @default.
• W2015840315 hasConcept C145103041 @default.
• W2015840315 hasConcept C148738053 @default.
• W2015840315 hasConcept C150194340 @default.
• W2015840315 hasConcept C158448853 @default.
• W2015840315 hasConcept C2777116130 @default.
• W2015840315 hasConcept C2780915607 @default.
• W2015840315 hasConcept C41091548 @default.
• W2015840315 hasConcept C54355233 @default.
• W2015840315 hasConcept C64927066 @default.
• W2015840315 hasConcept C83640560 @default.
• W2015840315 hasConcept C86803240 @default.
• W2015840315 hasConcept C95444343 @default.
• W2015840315 hasConcept C99854124 @default.
• W2015840315 hasConceptScore W2015840315C104317684 @default.
• W2015840315 hasConceptScore W2015840315C145103041 @default.
• W2015840315 hasConceptScore W2015840315C148738053 @default.
• W2015840315 hasConceptScore W2015840315C150194340 @default.
• W2015840315 hasConceptScore W2015840315C158448853 @default.
• W2015840315 hasConceptScore W2015840315C2777116130 @default.
• W2015840315 hasConceptScore W2015840315C2780915607 @default.
• W2015840315 hasConceptScore W2015840315C41091548 @default.
• W2015840315 hasConceptScore W2015840315C54355233 @default.
• W2015840315 hasConceptScore W2015840315C64927066 @default.
• W2015840315 hasConceptScore W2015840315C83640560 @default.
• W2015840315 hasConceptScore W2015840315C86803240 @default.
• W2015840315 hasConceptScore W2015840315C95444343 @default.
• W2015840315 hasConceptScore W2015840315C99854124 @default.
• W2015840315 hasIssue "1" @default.
• W2015840315 hasLocation W20158403151 @default.
• W2015840315 hasLocation W20158403152 @default.
• W2015840315 hasLocation W20158403153 @default.
• W2015840315 hasLocation W20158403154 @default.
• W2015840315 hasOpenAccess W2015840315 @default.

• next