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• W2015841298 abstract "Although mutations in the filaggrin gene (FLG) have been shown to be associated with ichthyosis vulgaris and atopic dermatitis, the function and regulation of filaggrin remain incompletely understood. In this issue, Hoste et al. report that filaggrin is directly cleaved by caspase-14. Acting in concert with other proteases, caspase-14 controls the breakdown of filaggrin to free amino acids and amino acid derivatives that contribute to the hydration and UVB absorption capacity of the stratum corneum. These findings identify a new layer of complexity in the regulation of epidermal barrier function." @default.
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• W2015841298 date "2011-11-01" @default.
• W2015841298 modified "2023-10-16" @default.
• W2015841298 title "Cuts by Caspase-14 Control the Proteolysis of Filaggrin" @default.
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• W2015841298 doi "https://doi.org/10.1038/jid.2011.282" @default.
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