FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015842304> ?p ?o ?g. }

• W2015842304 endingPage "363" @default.
• W2015842304 startingPage "357" @default.
• W2015842304 abstract "Cyclosporine A (CsA) is a potent and effective immunosuppressive agent, but its action is frequently accompanied by severe renal toxicity. The precise mechanism by which CsA causes renal injury is not known. Reactive oxygen species (ROS) have been shown to play a role, since CsA-induced renal lipid peroxidation is attenuated in vivo and in vitro by the concomitant administration of antioxidants such as vitamin E. We show here the effect of the antioxidant melatonin (MLT), a hormone produced by the pineal gland during the dark phase of the circadian cycle, in a model of CsA nephrotoxicity in the isolated and perfused rat kidney. Kidneys isolated from rats were divided into seven groups. At the end of perfusion, malondialdehyde and 4-hydroxyalkenals (MDA+4-HDA), metabolites of nitric oxide N O 2 &#109 +N O 3 &#109 were measured and histopathological examination was performed. CsA treatment induced a significant increase in MDA+4-HDA while not affecting the nitric oxide metabolite level. MLT remarkably prevented glomerular collapse and tubular damage as revealed by morphometric analysis. Our study suggests that lipid peroxidation is an early important event in the pathogenesis of CsA nephrotoxicity and that MLT is able to protect kidneys from CsA at a relatively low concentration." @default.
• W2015842304 created "2016-06-24" @default.
• W2015842304 creator A5034178337 @default.
• W2015842304 creator A5040642194 @default.
• W2015842304 creator A5041027656 @default.
• W2015842304 creator A5049957859 @default.
• W2015842304 creator A5052107768 @default.
• W2015842304 creator A5052506425 @default.
• W2015842304 creator A5069772556 @default.
• W2015842304 creator A5072567218 @default.
• W2015842304 creator A5072691840 @default.
• W2015842304 creator A5075277587 @default.
• W2015842304 date "2002-01-01" @default.
• W2015842304 modified "2023-09-27" @default.
• W2015842304 title "Melatonin Prevents Cyclosporine-induced Nephrotoxicity in Isolated and Perfused Rat Kidney" @default.
• W2015842304 cites W1491535877 @default.
• W2015842304 cites W1775749144 @default.
• W2015842304 cites W1964777340 @default.
• W2015842304 cites W1970585069 @default.
• W2015842304 cites W1972578850 @default.
• W2015842304 cites W1974250843 @default.
• W2015842304 cites W1975366846 @default.
• W2015842304 cites W1975715446 @default.
• W2015842304 cites W1980975219 @default.
• W2015842304 cites W1989893606 @default.
• W2015842304 cites W1990802251 @default.
• W2015842304 cites W2010037068 @default.
• W2015842304 cites W2011179099 @default.
• W2015842304 cites W2011445126 @default.
• W2015842304 cites W2020694286 @default.
• W2015842304 cites W2021492411 @default.
• W2015842304 cites W2035763067 @default.
• W2015842304 cites W2039705433 @default.
• W2015842304 cites W2041459681 @default.
• W2015842304 cites W2044283979 @default.
• W2015842304 cites W2046221239 @default.
• W2015842304 cites W2049155769 @default.
• W2015842304 cites W2056882404 @default.
• W2015842304 cites W2061608793 @default.
• W2015842304 cites W2063678928 @default.
• W2015842304 cites W2065633930 @default.
• W2015842304 cites W2072445299 @default.
• W2015842304 cites W2075696839 @default.
• W2015842304 cites W2085069461 @default.
• W2015842304 cites W2085198452 @default.
• W2015842304 cites W2091094196 @default.
• W2015842304 cites W2099000346 @default.
• W2015842304 cites W2117997371 @default.
• W2015842304 cites W2122283727 @default.
• W2015842304 cites W2127084081 @default.
• W2015842304 cites W2146381268 @default.
• W2015842304 cites W2160917955 @default.
• W2015842304 cites W2171390294 @default.
• W2015842304 cites W2171561094 @default.
• W2015842304 cites W2332176860 @default.
• W2015842304 cites W2409227388 @default.
• W2015842304 cites W2409931111 @default.
• W2015842304 cites W2411874599 @default.
• W2015842304 cites W2411939800 @default.
• W2015842304 cites W2413194698 @default.
• W2015842304 cites W2416866980 @default.
• W2015842304 cites W3216624875 @default.
• W2015842304 doi "https://doi.org/10.1080/10715760290019381" @default.
• W2015842304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12071355" @default.
• W2015842304 hasPublicationYear "2002" @default.
• W2015842304 type Work @default.
• W2015842304 sameAs 2015842304 @default.
• W2015842304 citedByCount "29" @default.
• W2015842304 countsByYear W20158423042012 @default.
• W2015842304 countsByYear W20158423042013 @default.
• W2015842304 countsByYear W20158423042014 @default.
• W2015842304 countsByYear W20158423042019 @default.
• W2015842304 countsByYear W20158423042020 @default.
• W2015842304 countsByYear W20158423042021 @default.
• W2015842304 crossrefType "journal-article" @default.
• W2015842304 hasAuthorship W2015842304A5034178337 @default.
• W2015842304 hasAuthorship W2015842304A5040642194 @default.
• W2015842304 hasAuthorship W2015842304A5041027656 @default.
• W2015842304 hasAuthorship W2015842304A5049957859 @default.
• W2015842304 hasAuthorship W2015842304A5052107768 @default.
• W2015842304 hasAuthorship W2015842304A5052506425 @default.
• W2015842304 hasAuthorship W2015842304A5069772556 @default.
• W2015842304 hasAuthorship W2015842304A5072567218 @default.
• W2015842304 hasAuthorship W2015842304A5072691840 @default.
• W2015842304 hasAuthorship W2015842304A5075277587 @default.
• W2015842304 hasConcept C126189478 @default.
• W2015842304 hasConcept C126322002 @default.
• W2015842304 hasConcept C134018914 @default.
• W2015842304 hasConcept C185592680 @default.
• W2015842304 hasConcept C2776151105 @default.
• W2015842304 hasConcept C2777477808 @default.
• W2015842304 hasConcept C2778182776 @default.
• W2015842304 hasConcept C2778401633 @default.
• W2015842304 hasConcept C2780091579 @default.
• W2015842304 hasConcept C2780829032 @default.
• W2015842304 hasConcept C48349386 @default.
• W2015842304 hasConcept C519581460 @default.
• W2015842304 hasConcept C55493867 @default.

• next