FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015848106> ?p ?o ?g. }

• W2015848106 endingPage "432" @default.
• W2015848106 startingPage "427" @default.
• W2015848106 abstract "An in vitro model was designed to evaluate the efficacy of instilled antimicrobials to reduce or eliminate intraluminal microbial colonization. Minimal inhibitory concentration and minimal bactericidal concentration activity of appropriate test anti-infectives were determined using standard methodology against clinically derived and reference test strains commonly associated with catheter-related infection. Drug activity was validated by bioassay for the test anti-infectives. Reference and clinical test strains were inoculated to the intraluminal surface of silicone catheter segments and incubated for 30 min, after which the inoculum was replaced with total parenteral nutrition (TPN) solution and reincubated for 12 h. For 7 d, instillation of antibiotic and TPN solution was alternated every 12 h to simulate clinical conditions. On days 1, 4, and 7, catheter segments were rinsed, bisected, and sonicated for quantitative plate count to determine mean microbial counts per centimeter of catheter surface. Catheter segments were also prepared for scanning electron microscopy. A significant decrease in staphylococcal intraluminal colonization after instillation of nafcillin, ceftriaxone, gentamicin, and vancomycin was demonstrated (P < 0.001). Aztreonam, ceftriaxone, and gentamicin completely eliminated gram-negative catheter colonization (P < 0.001). Yeast was eradicated from the internal catheter surface after treatment with amphoteracin B, and fluconazole significantly decreased intraluminal colonization (P < 0.001). Results show a significant decrease in staphylococcal, gram-negative, and fungal intraluminal colonization after instillation of appropriate antimicrobial. In vitro results support early clinical success using this technique. Future studies are warranted to identify optimal drug concentrations and dosing intervals." @default.
• W2015848106 created "2016-06-24" @default.
• W2015848106 creator A5001986585 @default.
• W2015848106 creator A5014575450 @default.
• W2015848106 creator A5087622470 @default.
• W2015848106 creator A5088557193 @default.
• W2015848106 creator A5090413943 @default.
• W2015848106 date "1998-05-01" @default.
• W2015848106 modified "2023-09-23" @default.
• W2015848106 title "Elimination of Intraluminal Colonization by Antibiotic Lock in Silicone Vascular Catheters" @default.
• W2015848106 cites W1605229291 @default.
• W2015848106 cites W1851660612 @default.
• W2015848106 cites W1928272017 @default.
• W2015848106 cites W1949131150 @default.
• W2015848106 cites W1975311646 @default.
• W2015848106 cites W1981264854 @default.
• W2015848106 cites W1988804370 @default.
• W2015848106 cites W1991425986 @default.
• W2015848106 cites W1995077462 @default.
• W2015848106 cites W2004383745 @default.
• W2015848106 cites W2005815739 @default.
• W2015848106 cites W2017205742 @default.
• W2015848106 cites W2019486245 @default.
• W2015848106 cites W2022698064 @default.
• W2015848106 cites W2025636832 @default.
• W2015848106 cites W2041255052 @default.
• W2015848106 cites W2041354784 @default.
• W2015848106 cites W2042659762 @default.
• W2015848106 cites W2043641114 @default.
• W2015848106 cites W2050977335 @default.
• W2015848106 cites W2051163690 @default.
• W2015848106 cites W2059761004 @default.
• W2015848106 cites W2076570067 @default.
• W2015848106 cites W2089511414 @default.
• W2015848106 cites W2093134993 @default.
• W2015848106 cites W2097396619 @default.
• W2015848106 cites W2112338382 @default.
• W2015848106 cites W2123587492 @default.
• W2015848106 cites W2159568475 @default.
• W2015848106 cites W2166785990 @default.
• W2015848106 cites W2168052328 @default.
• W2015848106 cites W2313875412 @default.
• W2015848106 cites W569670396 @default.
• W2015848106 cites W54757077 @default.
• W2015848106 doi "https://doi.org/10.1016/s0899-9007(98)00013-6" @default.
• W2015848106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9614306" @default.
• W2015848106 hasPublicationYear "1998" @default.
• W2015848106 type Work @default.
• W2015848106 sameAs 2015848106 @default.
• W2015848106 citedByCount "60" @default.
• W2015848106 countsByYear W20158481062012 @default.
• W2015848106 countsByYear W20158481062013 @default.
• W2015848106 countsByYear W20158481062014 @default.
• W2015848106 countsByYear W20158481062015 @default.
• W2015848106 countsByYear W20158481062019 @default.
• W2015848106 crossrefType "journal-article" @default.
• W2015848106 hasAuthorship W2015848106A5001986585 @default.
• W2015848106 hasAuthorship W2015848106A5014575450 @default.
• W2015848106 hasAuthorship W2015848106A5087622470 @default.
• W2015848106 hasAuthorship W2015848106A5088557193 @default.
• W2015848106 hasAuthorship W2015848106A5090413943 @default.
• W2015848106 hasConcept C141071460 @default.
• W2015848106 hasConcept C176947019 @default.
• W2015848106 hasConcept C178790620 @default.
• W2015848106 hasConcept C185592680 @default.
• W2015848106 hasConcept C2775832221 @default.
• W2015848106 hasConcept C2776520383 @default.
• W2015848106 hasConcept C2776927270 @default.
• W2015848106 hasConcept C2777762789 @default.
• W2015848106 hasConcept C2778980435 @default.
• W2015848106 hasConcept C2779489039 @default.
• W2015848106 hasConcept C2779769944 @default.
• W2015848106 hasConcept C2781267111 @default.
• W2015848106 hasConcept C501593827 @default.
• W2015848106 hasConcept C523546767 @default.
• W2015848106 hasConcept C54355233 @default.
• W2015848106 hasConcept C71924100 @default.
• W2015848106 hasConcept C86803240 @default.
• W2015848106 hasConcept C89423630 @default.
• W2015848106 hasConceptScore W2015848106C141071460 @default.
• W2015848106 hasConceptScore W2015848106C176947019 @default.
• W2015848106 hasConceptScore W2015848106C178790620 @default.
• W2015848106 hasConceptScore W2015848106C185592680 @default.
• W2015848106 hasConceptScore W2015848106C2775832221 @default.
• W2015848106 hasConceptScore W2015848106C2776520383 @default.
• W2015848106 hasConceptScore W2015848106C2776927270 @default.
• W2015848106 hasConceptScore W2015848106C2777762789 @default.
• W2015848106 hasConceptScore W2015848106C2778980435 @default.
• W2015848106 hasConceptScore W2015848106C2779489039 @default.
• W2015848106 hasConceptScore W2015848106C2779769944 @default.
• W2015848106 hasConceptScore W2015848106C2781267111 @default.
• W2015848106 hasConceptScore W2015848106C501593827 @default.
• W2015848106 hasConceptScore W2015848106C523546767 @default.
• W2015848106 hasConceptScore W2015848106C54355233 @default.
• W2015848106 hasConceptScore W2015848106C71924100 @default.
• W2015848106 hasConceptScore W2015848106C86803240 @default.
• W2015848106 hasConceptScore W2015848106C89423630 @default.
• W2015848106 hasIssue "5" @default.

• next