FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015860897> ?p ?o ?g. }

• W2015860897 endingPage "867" @default.
• W2015860897 startingPage "859" @default.
• W2015860897 abstract "Three structural variants of the joining peptide (JP) fragment of POMC have been purified from human pituitaries. Ion exchange and reverse phase tissue extraction procedures were combined with reverse phase HPLC to achieve complete purification of each form of JP. Fragments resulting from tryptic hydrolysis of each form were characterized by amino acid analysis and fast atom bombardment mass spectrometry. The predominant form of human JP, accounting for about 50% of the total purified, was found to be conjugated to glutathione through the lone cysteine residue at position 9. The other two variants were identified as human JP with a free cysteine residue and human JP dimer and accounted for 35% and 15%, respectively, of the total purified. Recently, human JP-(1-18) has been suggested as having adrenal androgen-stimulating activity. None of the three JP variants or their respective 1-20 amino-terminal fragments resulting from tryptic hydrolysis showed any ability to promote the secretion of dehydroepiandrosterone sulfate by cultured human fetal adrenal cells. Similarly, no potentiation of the stimulatory effects of ACTH-(1-39) was observed. The three variants of human JP as well as JP purified from rat, porcine, and bovine pituitaries were tested for their ability to stimulate androgenic steroids from dispersed fetal rabbit adrenal cells. None showed any significant biological activity either in stimulating steroid secretion or in potentiating the action of ACTH-(1-39)." @default.
• W2015860897 created "2016-06-24" @default.
• W2015860897 creator A5022958816 @default.
• W2015860897 creator A5047861913 @default.
• W2015860897 creator A5048969599 @default.
• W2015860897 creator A5049352534 @default.
• W2015860897 creator A5051332798 @default.
• W2015860897 creator A5057037965 @default.
• W2015860897 creator A5073525642 @default.
• W2015860897 date "1991-08-01" @default.
• W2015860897 modified "2023-10-16" @default.
• W2015860897 title "Isolation and Characterization of Three Forms of Joining Peptide from Adult Human Pituitaries: Lack of Adrenal Androgen-Stimulating Activity*" @default.
• W2015860897 cites W1027995038 @default.
• W2015860897 cites W1497531311 @default.
• W2015860897 cites W1498572024 @default.
• W2015860897 cites W1551834526 @default.
• W2015860897 cites W1590965772 @default.
• W2015860897 cites W1963864469 @default.
• W2015860897 cites W1964988005 @default.
• W2015860897 cites W1966169901 @default.
• W2015860897 cites W1967426812 @default.
• W2015860897 cites W1972932678 @default.
• W2015860897 cites W1978040083 @default.
• W2015860897 cites W1978946812 @default.
• W2015860897 cites W1982016187 @default.
• W2015860897 cites W1983882926 @default.
• W2015860897 cites W1984319724 @default.
• W2015860897 cites W1987644167 @default.
• W2015860897 cites W1987860847 @default.
• W2015860897 cites W199746022 @default.
• W2015860897 cites W1998858772 @default.
• W2015860897 cites W2004105388 @default.
• W2015860897 cites W2020956104 @default.
• W2015860897 cites W2025975898 @default.
• W2015860897 cites W2027002682 @default.
• W2015860897 cites W2028119873 @default.
• W2015860897 cites W2029418050 @default.
• W2015860897 cites W2031634506 @default.
• W2015860897 cites W2041584824 @default.
• W2015860897 cites W2048721456 @default.
• W2015860897 cites W2051570638 @default.
• W2015860897 cites W2052788650 @default.
• W2015860897 cites W2060784711 @default.
• W2015860897 cites W2089018293 @default.
• W2015860897 cites W2115413512 @default.
• W2015860897 cites W2138563371 @default.
• W2015860897 cites W2168926466 @default.
• W2015860897 cites W2335743724 @default.
• W2015860897 doi "https://doi.org/10.1210/endo-129-2-859" @default.
• W2015860897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1830271" @default.
• W2015860897 hasPublicationYear "1991" @default.
• W2015860897 type Work @default.
• W2015860897 sameAs 2015860897 @default.
• W2015860897 citedByCount "21" @default.
• W2015860897 countsByYear W20158608972016 @default.
• W2015860897 countsByYear W20158608972018 @default.
• W2015860897 countsByYear W20158608972022 @default.
• W2015860897 crossrefType "journal-article" @default.
• W2015860897 hasAuthorship W2015860897A5022958816 @default.
• W2015860897 hasAuthorship W2015860897A5047861913 @default.
• W2015860897 hasAuthorship W2015860897A5048969599 @default.
• W2015860897 hasAuthorship W2015860897A5049352534 @default.
• W2015860897 hasAuthorship W2015860897A5051332798 @default.
• W2015860897 hasAuthorship W2015860897A5057037965 @default.
• W2015860897 hasAuthorship W2015860897A5073525642 @default.
• W2015860897 hasConcept C116073593 @default.
• W2015860897 hasConcept C126322002 @default.
• W2015860897 hasConcept C134018914 @default.
• W2015860897 hasConcept C162356407 @default.
• W2015860897 hasConcept C181199279 @default.
• W2015860897 hasConcept C185592680 @default.
• W2015860897 hasConcept C199033913 @default.
• W2015860897 hasConcept C202751555 @default.
• W2015860897 hasConcept C2776992908 @default.
• W2015860897 hasConcept C2777911890 @default.
• W2015860897 hasConcept C2779201268 @default.
• W2015860897 hasConcept C2779281246 @default.
• W2015860897 hasConcept C2781338088 @default.
• W2015860897 hasConcept C43617362 @default.
• W2015860897 hasConcept C515207424 @default.
• W2015860897 hasConcept C55493867 @default.
• W2015860897 hasConcept C71315377 @default.
• W2015860897 hasConcept C71924100 @default.
• W2015860897 hasConcept C86803240 @default.
• W2015860897 hasConceptScore W2015860897C116073593 @default.
• W2015860897 hasConceptScore W2015860897C126322002 @default.
• W2015860897 hasConceptScore W2015860897C134018914 @default.
• W2015860897 hasConceptScore W2015860897C162356407 @default.
• W2015860897 hasConceptScore W2015860897C181199279 @default.
• W2015860897 hasConceptScore W2015860897C185592680 @default.
• W2015860897 hasConceptScore W2015860897C199033913 @default.
• W2015860897 hasConceptScore W2015860897C202751555 @default.
• W2015860897 hasConceptScore W2015860897C2776992908 @default.
• W2015860897 hasConceptScore W2015860897C2777911890 @default.
• W2015860897 hasConceptScore W2015860897C2779201268 @default.
• W2015860897 hasConceptScore W2015860897C2779281246 @default.
• W2015860897 hasConceptScore W2015860897C2781338088 @default.
• W2015860897 hasConceptScore W2015860897C43617362 @default.

• next