Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015864197> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2015864197 endingPage "234" @default.
- W2015864197 startingPage "223" @default.
- W2015864197 abstract "An asymmetric rutheniumIII complex containing dimethylsulphoxide ligands, namely mer-trichlorobisdimethylsulphoxideaminorutheniumIII (BBR2382), has been tested in mice bearing solid metastasizing tumors. The effects of i.p. treatment with BBR2382 on primary tumor growth and on the survival time of hosts carrying s.c. or i.m. tumors have been compared to those of cisplatin and of a rutheniumIII complex with imidazole ligands, ImH[RuIm2Cl4], described as a potent antitumor agent in a number of experimental models of murine neoplasms. In mice bearing Lewis lung carcinoma, BBR2382 results as effective as cisplatin on s.c. primary tumor growth and more potent than cisplatin on the prolongation of host survival time. The combined treatment of mice bearing Lewis lung carcinoma with cisplatin and BBR2382 causes a reduction of s.c. tumors higher than that caused by each single agent; the effects on host survival time are similar to those caused by BBR2382 alone but significantly superior to those caused by cisplatin alone. In CBA mice bearing MCa mammary carcinoma, the effects of BBR2382 are slightly lower than those of cisplatin on i.m. tumors but are equivalent on host survival time. The comparison of the antineoplastic action of BBR2382 with that of ImH[RuIm2Cl4] is always in favor of the former, independently of the parameter chosen and of the tumor system used. Qualitatively, the antitumor action of BBR2382 seems different from that of cisplatin and of ImH[RuIm2Cl4]; it is supposed that this agent, like other «rutheniumIII dimethylsulphoxideå complexes, could have a particular efficacy for tumors localized in the lungs." @default.
- W2015864197 created "2016-06-24" @default.
- W2015864197 creator A5005262464 @default.
- W2015864197 creator A5007999770 @default.
- W2015864197 creator A5014774166 @default.
- W2015864197 creator A5015109478 @default.
- W2015864197 creator A5027632014 @default.
- W2015864197 creator A5032743567 @default.
- W2015864197 date "1991-01-01" @default.
- W2015864197 modified "2023-10-10" @default.
- W2015864197 title "Antineoplastic effects of mer-trichlorobisdimethylsulphoxideaminorutheniumIII against murine tumors: Comparison with cisplatin and with ImH[RuIm2Cl4]" @default.
- W2015864197 cites W1965382965 @default.
- W2015864197 cites W1969773136 @default.
- W2015864197 cites W1978140112 @default.
- W2015864197 cites W1992853944 @default.
- W2015864197 cites W1999023373 @default.
- W2015864197 cites W2020040838 @default.
- W2015864197 cites W2047277761 @default.
- W2015864197 cites W2058145527 @default.
- W2015864197 cites W2065007250 @default.
- W2015864197 cites W2071968682 @default.
- W2015864197 doi "https://doi.org/10.1016/0009-2797(91)90016-z" @default.
- W2015864197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2040026" @default.
- W2015864197 hasPublicationYear "1991" @default.
- W2015864197 type Work @default.
- W2015864197 sameAs 2015864197 @default.
- W2015864197 citedByCount "22" @default.
- W2015864197 countsByYear W20158641972016 @default.
- W2015864197 countsByYear W20158641972019 @default.
- W2015864197 crossrefType "journal-article" @default.
- W2015864197 hasAuthorship W2015864197A5005262464 @default.
- W2015864197 hasAuthorship W2015864197A5007999770 @default.
- W2015864197 hasAuthorship W2015864197A5014774166 @default.
- W2015864197 hasAuthorship W2015864197A5015109478 @default.
- W2015864197 hasAuthorship W2015864197A5027632014 @default.
- W2015864197 hasAuthorship W2015864197A5032743567 @default.
- W2015864197 hasConcept C121608353 @default.
- W2015864197 hasConcept C126322002 @default.
- W2015864197 hasConcept C185592680 @default.
- W2015864197 hasConcept C202751555 @default.
- W2015864197 hasConcept C2776120743 @default.
- W2015864197 hasConcept C2776694085 @default.
- W2015864197 hasConcept C2777546739 @default.
- W2015864197 hasConcept C2777847059 @default.
- W2015864197 hasConcept C2778239845 @default.
- W2015864197 hasConcept C2779013556 @default.
- W2015864197 hasConcept C502942594 @default.
- W2015864197 hasConcept C55493867 @default.
- W2015864197 hasConcept C71924100 @default.
- W2015864197 hasConcept C98274493 @default.
- W2015864197 hasConceptScore W2015864197C121608353 @default.
- W2015864197 hasConceptScore W2015864197C126322002 @default.
- W2015864197 hasConceptScore W2015864197C185592680 @default.
- W2015864197 hasConceptScore W2015864197C202751555 @default.
- W2015864197 hasConceptScore W2015864197C2776120743 @default.
- W2015864197 hasConceptScore W2015864197C2776694085 @default.
- W2015864197 hasConceptScore W2015864197C2777546739 @default.
- W2015864197 hasConceptScore W2015864197C2777847059 @default.
- W2015864197 hasConceptScore W2015864197C2778239845 @default.
- W2015864197 hasConceptScore W2015864197C2779013556 @default.
- W2015864197 hasConceptScore W2015864197C502942594 @default.
- W2015864197 hasConceptScore W2015864197C55493867 @default.
- W2015864197 hasConceptScore W2015864197C71924100 @default.
- W2015864197 hasConceptScore W2015864197C98274493 @default.
- W2015864197 hasIssue "2" @default.
- W2015864197 hasLocation W20158641971 @default.
- W2015864197 hasLocation W20158641972 @default.
- W2015864197 hasOpenAccess W2015864197 @default.
- W2015864197 hasPrimaryLocation W20158641971 @default.
- W2015864197 hasRelatedWork W1991884873 @default.
- W2015864197 hasRelatedWork W2015864197 @default.
- W2015864197 hasRelatedWork W2091461259 @default.
- W2015864197 hasRelatedWork W2149068418 @default.
- W2015864197 hasRelatedWork W2362787741 @default.
- W2015864197 hasRelatedWork W2406596433 @default.
- W2015864197 hasRelatedWork W2406608798 @default.
- W2015864197 hasRelatedWork W2415181285 @default.
- W2015864197 hasRelatedWork W2460036924 @default.
- W2015864197 hasRelatedWork W3120025342 @default.
- W2015864197 hasVolume "78" @default.
- W2015864197 isParatext "false" @default.
- W2015864197 isRetracted "false" @default.
- W2015864197 magId "2015864197" @default.
- W2015864197 workType "article" @default.