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• W2015868082 abstract "Isolated single pancreatic acinar cells have long been used as a model for studying many kinds of signaling processes due to their structural and functional polarities, but without significant validation. In this study, we examined the morphological and functional changes of dissociated single pancreatic acinar cells. Acutely isolated single cells showed a collapsed membrane potential and a much reduced secretion of zymogen granules in response to acetylcholine (ACh) stimulation, whereas clustered cells showed a much more negative membrane potential and potent exocytotic secretion. The isolated single cells became vertically flattened due to the loss of supporting adhesions with nearby cells, and the granule-attached luminal membrane was severely reduced versus that of clustered cells. However, polarized Ca(2+) signals and mitochondrial localizations were relatively well preserved in the isolated single cells, in that Ca(2+) release by ACh commenced at the indented luminal membrane. In clusters, the Ca(2+) release site was closest to the lumen where more than three cells met or at the tips of conical regions of the luminal membrane. These findings suggest that the dissociated single pancreatic acinar cells preserve an intact Ca(2+) signaling machinery but alter in shape and have impaired exocytotic functions and resting membrane potentials." @default.
• W2015868082 created "2016-06-24" @default.
• W2015868082 creator A5005787220 @default.
• W2015868082 creator A5011001216 @default.
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• W2015868082 date "2004-04-01" @default.
• W2015868082 modified "2023-09-23" @default.
• W2015868082 title "Morphological and functional changes of dissociated single pancreatic acinar cells: testing the suitability of the single cell as a model for exocytosis and calcium signaling" @default.
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• W2015868082 doi "https://doi.org/10.1016/j.ceca.2003.10.003" @default.
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