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- W2015869969 abstract "The key event for antimicrobial action begins when streptomycin binds to the 30S subunit (S12 protein) of a ribosome. Lysine 42 and lysine 87 are involved. It is proposed that antagonism of acetyl coenzyme A carboxylase by streptomycin results in faulty fatty acids, lipids and derivatives marked exclusively for cell membrane synthesis. Streptomycin-sensitive growing cells are fatally wounded when defective membranes leak K(+) ions, then amino acids, nucleotides, oligonucleotides and proteins as increasing amounts of streptomycin enter the cell." @default.
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- W2015869969 date "2002-01-01" @default.
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- W2015869969 title "Streptomycin revisited: molecular action in the microbial cell" @default.
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- W2015869969 doi "https://doi.org/10.1054/mehy.2001.1450" @default.
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