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- W2015870565 abstract "SINCE chlorpromazine was introduced in 1952, the list of phenothiazines causing cholestasis has grown considerably. In addition to chlorpromazine, other icterogenic phenothiazines are promazine, prochlorperazine, mepazine, and trifluoperazine. 1 This complication occurs in less than 1% of individuals taking phenothiazines. 1,2 Phenothiazine cholestasis is benign and almost always remits when the offending drug is discontinued. 1-5 In fact there may be remission of jaundice while the drug is being administered. 4 Cases are reported in which there was progression of the condition to xanthomatous biliary cirrhosis. 1-3,5,6 Cohen has recently stated that an unequivocal case of jaundice due to thioridazine is not known. 2 In 1959, Block 7 reported jaundice in a 79-year-old woman who was administered modest doses of thioridazine for a nine-month period. At the end of that time, her bilirubin level was 1.2 mg/100 ml and her transaminase level was elevated. Within two weeks of stopping thioridazine," @default.
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- W2015870565 date "1967-04-03" @default.
- W2015870565 modified "2023-09-26" @default.
- W2015870565 title "Thioridazine-Induced Cholestasis" @default.
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- W2015870565 doi "https://doi.org/10.1001/jama.1967.03120140127031" @default.
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