Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015875115> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2015875115 endingPage "250" @default.
- W2015875115 startingPage "241" @default.
- W2015875115 abstract "In isolated tissue from the human corpus spongiosum urethrae (CS) the effects of adrenoreceptor and muscarinic receptor active drugs on release of 3H-noradrenaline (NA) from noradrenergic nerves and on isometric tension were investigated. The electrically induced release of 3H was reduced by clonidine (alpha 2-adrenoreceptor agonist), increased by rauwolscine (alpha 2-adrenoreceptor antagonist), and little affected by phenylephrine (alpha 1-adrenoreceptor agonist) and prazosin (alpha 1-adrenoreceptor antagonist). Isoprenaline (beta 1- and beta 2-adrenoreceptor agonist) and procaterol (beta 2-adrenoreceptor agonist) increased the release, propranolol (beta 1- and beta 2-adrenoreceptor antagonist) reduced it, and prenalterol (beta 1-adrenoreceptor agonist) and atenolol (beta 1-adrenoreceptor antagonist) had no effect. Carbachol (muscarinic receptor agonist) decreased and scopolamine (muscarinic receptor antagonist) increased stimulation-induced efflux of 3H. NA, phenylephrine and clonidine contracted isolated CS preparations, clonidine being less potent and having less intrinsic activity than phenylephrine. Prazosin was more effective than rauwolscine for inhibition of NA-induced contractions, and prazosin, but not rauwolscine, abolished electrically induced contractions. Isoprenaline and procaterol, but not prenalterol, relaxed NA-contracted preparations. These relaxations could be blocked by propranolol but not by atenolol. Acetylcholine and carbachol relaxed NA-contracted preparations but had no contractant effect on any of the preparations tested. The results suggest that prejunctionally in the human CS, the alpha-adrenoreceptors are of alpha 2-type and the beta-adrenoreceptors of beta 2-type. Postjunctionally, the main alpha-adrenoreceptor function seems to be of alpha 1-type and the beta-adrenoreceptor function of beta 2-type. Stimulation of muscarinic receptors may inhibit the effects of NA both by decreasing its release from noradrenergic nerves and by counteracting its postjunctional effects." @default.
- W2015875115 created "2016-06-24" @default.
- W2015875115 creator A5014135786 @default.
- W2015875115 creator A5021724731 @default.
- W2015875115 creator A5074586285 @default.
- W2015875115 date "1984-12-01" @default.
- W2015875115 modified "2023-10-18" @default.
- W2015875115 title "PRE- AND POSTJUNCTIONAL ADRENO- AND MUSCARINIC RECEPTOR FUNCTIONS IN THE ISOLATED HUMAN CORPUS SPONGIOSUM URETHRAE" @default.
- W2015875115 cites W149841458 @default.
- W2015875115 cites W186872926 @default.
- W2015875115 cites W1976813428 @default.
- W2015875115 cites W1995924675 @default.
- W2015875115 cites W2009131432 @default.
- W2015875115 cites W2031224797 @default.
- W2015875115 cites W2032002405 @default.
- W2015875115 cites W2040388774 @default.
- W2015875115 cites W2049704766 @default.
- W2015875115 cites W2078913760 @default.
- W2015875115 cites W2090831592 @default.
- W2015875115 cites W2417725540 @default.
- W2015875115 cites W2477432669 @default.
- W2015875115 doi "https://doi.org/10.1111/j.1474-8673.1984.tb00101.x" @default.
- W2015875115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6152266" @default.
- W2015875115 hasPublicationYear "1984" @default.
- W2015875115 type Work @default.
- W2015875115 sameAs 2015875115 @default.
- W2015875115 citedByCount "41" @default.
- W2015875115 countsByYear W20158751152013 @default.
- W2015875115 crossrefType "journal-article" @default.
- W2015875115 hasAuthorship W2015875115A5014135786 @default.
- W2015875115 hasAuthorship W2015875115A5021724731 @default.
- W2015875115 hasAuthorship W2015875115A5074586285 @default.
- W2015875115 hasConcept C126322002 @default.
- W2015875115 hasConcept C134018914 @default.
- W2015875115 hasConcept C170493617 @default.
- W2015875115 hasConcept C185592680 @default.
- W2015875115 hasConcept C24998067 @default.
- W2015875115 hasConcept C2776090920 @default.
- W2015875115 hasConcept C2776504411 @default.
- W2015875115 hasConcept C2776525901 @default.
- W2015875115 hasConcept C2776885963 @default.
- W2015875115 hasConcept C2777676773 @default.
- W2015875115 hasConcept C2777952589 @default.
- W2015875115 hasConcept C2778151854 @default.
- W2015875115 hasConcept C2778938600 @default.
- W2015875115 hasConcept C2778988552 @default.
- W2015875115 hasConcept C2780648677 @default.
- W2015875115 hasConcept C71924100 @default.
- W2015875115 hasConcept C84393581 @default.
- W2015875115 hasConcept C86803240 @default.
- W2015875115 hasConceptScore W2015875115C126322002 @default.
- W2015875115 hasConceptScore W2015875115C134018914 @default.
- W2015875115 hasConceptScore W2015875115C170493617 @default.
- W2015875115 hasConceptScore W2015875115C185592680 @default.
- W2015875115 hasConceptScore W2015875115C24998067 @default.
- W2015875115 hasConceptScore W2015875115C2776090920 @default.
- W2015875115 hasConceptScore W2015875115C2776504411 @default.
- W2015875115 hasConceptScore W2015875115C2776525901 @default.
- W2015875115 hasConceptScore W2015875115C2776885963 @default.
- W2015875115 hasConceptScore W2015875115C2777676773 @default.
- W2015875115 hasConceptScore W2015875115C2777952589 @default.
- W2015875115 hasConceptScore W2015875115C2778151854 @default.
- W2015875115 hasConceptScore W2015875115C2778938600 @default.
- W2015875115 hasConceptScore W2015875115C2778988552 @default.
- W2015875115 hasConceptScore W2015875115C2780648677 @default.
- W2015875115 hasConceptScore W2015875115C71924100 @default.
- W2015875115 hasConceptScore W2015875115C84393581 @default.
- W2015875115 hasConceptScore W2015875115C86803240 @default.
- W2015875115 hasIssue "4" @default.
- W2015875115 hasLocation W20158751151 @default.
- W2015875115 hasLocation W20158751152 @default.
- W2015875115 hasOpenAccess W2015875115 @default.
- W2015875115 hasPrimaryLocation W20158751151 @default.
- W2015875115 hasRelatedWork W1989207201 @default.
- W2015875115 hasRelatedWork W2000884187 @default.
- W2015875115 hasRelatedWork W2015875115 @default.
- W2015875115 hasRelatedWork W2052492309 @default.
- W2015875115 hasRelatedWork W2052706297 @default.
- W2015875115 hasRelatedWork W2053650671 @default.
- W2015875115 hasRelatedWork W2054573554 @default.
- W2015875115 hasRelatedWork W2080092117 @default.
- W2015875115 hasRelatedWork W2082166484 @default.
- W2015875115 hasRelatedWork W2411476455 @default.
- W2015875115 hasVolume "4" @default.
- W2015875115 isParatext "false" @default.
- W2015875115 isRetracted "false" @default.
- W2015875115 magId "2015875115" @default.
- W2015875115 workType "article" @default.