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• W2015890653 endingPage "499" @default.
• W2015890653 startingPage "494" @default.
• W2015890653 abstract "Nucleotide excision repair is a constitutive stress response that eliminates DNA lesions induced by multiple genotoxic agents. Unlike the immune system, which generates billions of immunoglobulins and T cell receptors for antigen recognition, the nucleotide excision repair complex uses only a few generic factors to detect an astounding diversity of DNA modifications. New data favor an unexpected strategy whereby damage recognition is initiated by the detection of abnormal oscillations in the undamaged strand opposite to DNA lesions. Another core subunit recognizes the increased susceptibility of DNA to be kinked at injured sites. We suggest that early nucleotide excision repair factors gain substrate versatility by avoiding direct contacts with modified residues and exploiting instead the altered dynamics of damaged DNA duplexes. Nucleotide excision repair is a constitutive stress response that eliminates DNA lesions induced by multiple genotoxic agents. Unlike the immune system, which generates billions of immunoglobulins and T cell receptors for antigen recognition, the nucleotide excision repair complex uses only a few generic factors to detect an astounding diversity of DNA modifications. New data favor an unexpected strategy whereby damage recognition is initiated by the detection of abnormal oscillations in the undamaged strand opposite to DNA lesions. Another core subunit recognizes the increased susceptibility of DNA to be kinked at injured sites. We suggest that early nucleotide excision repair factors gain substrate versatility by avoiding direct contacts with modified residues and exploiting instead the altered dynamics of damaged DNA duplexes." @default.
• W2015890653 created "2016-06-24" @default.
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• W2015890653 date "2007-11-01" @default.
• W2015890653 modified "2023-09-23" @default.
• W2015890653 title "DNA repair triggered by sensors of helical dynamics" @default.
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• W2015890653 doi "https://doi.org/10.1016/j.tibs.2007.08.008" @default.
• W2015890653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17962020" @default.
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