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• W2015896825 abstract "Abstract. The pathophysiologic mechanism behind microalbuminuria, a potential atherosclerotic risk factor, was explored by measuring fractional clearances of four endogenous plasma proteins of different size and electric charge (albumin, β2-microglobulin, immunoglobulin G, and immunoglobulin G4). Twenty-eight clinically healthy individuals with microalbuminuria, defined as a urinary albumin excretion of 6.6–150μg min-1, and 60 matched control subjects were studied. Fractional immunoglobulin G clearance was higher (geometric means (95% confidence intervals)) 3.0 (2.3–3.9) × 10-6, n= 28, vs. 2.1 (1.8–2.4) × 10-6, n= 60; P= 0.02), whereas the ratio immunoglobulin G clearance/immunoglobulin G4 clearance was lower (geometric means (95% confidence intervals)) 1.8 (1.4–2.2), n= 28, vs. 2.3 (2.0–2.5), n= 60; P= 0.03) in microalbuminuric than in normoalbuminuric individuals. Fractional β2-micro-globulin clearance was similar in the two groups. Since total IgG and the IgG4 subclass are of similar size and configuration but electrically neutral and negative, respectively; these findings indicate that microalbuminuria is associated with decreased size- and charge-selectivity of the glomerular vessel wall. Hypotheti-cally, such alterations may reflect generalized vascular abnormalities linking microalbuminuria to athero-genesis." @default.
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• W2015896825 date "1995-08-01" @default.
• W2015896825 modified "2023-09-25" @default.
• W2015896825 title "Reduced glomerular size- and charge-selectivity in clinically healthy individuals with microalbuminuria" @default.
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• W2015896825 doi "https://doi.org/10.1111/j.1365-2362.1995.tb01753.x" @default.
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