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- W2015897818 abstract "Immunological evaluations (lymphocyte markers, B cell differentiation, T cell function) were performed on peripheral blood mononuclear cells from four individuals with hyper IgM immunodeficiency. Number, proportion, and proliferation of T lymphocytes and T lymphocyte subpopulations were relatively normal in affected individuals. The percentage and number of B cells expressing surface IgM and IgD were either normal or elevated in both blood and lymph nodes. However, surface IgG- and IgA-bearing B lymphocytes were completely absent. In vitro stimulation of blood lymphocytes with both T cell-dependent and T-cell independent polyclonal B cell activators resulted in normal numbers of IgM plasma cells and IgM secretion in cultures, but failed to induce any IgG- or IgA-producing cells. This failure of isotype switching was intrinsic to the B cell population and did not involve aberrant T cell help or suppression. Therefore, individuals with this disorder possess an intrinsic B cell dysfunction that is not related to abnormal T cell regulation." @default.
- W2015897818 created "2016-06-24" @default.
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- W2015897818 date "1983-11-01" @default.
- W2015897818 modified "2023-10-16" @default.
- W2015897818 title "Hyper IgM immunodeficiency. A primary dysfunction of B lymphocyte isotype switching." @default.
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- W2015897818 doi "https://doi.org/10.1172/jci111124" @default.
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