FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015901914> ?p ?o ?g. }

• W2015901914 endingPage "594" @default.
• W2015901914 startingPage "583" @default.
• W2015901914 abstract "Metformin, an extensively used and well-tolerated drug for treating individuals with type 2 diabetes, has recently gained significant attention as an anticancer drug. On the other hand, paclitaxel (Taxol) is a new antineoplastic drug that has shown promise in the treatment of non-small cell lung cancer (NSCLC). High expression levels of excision repair cross-complementary 1 (ERCC1) in cancers have been positively associated with the DNA repair capacity and a poor prognosis in NSCLC patients treated with platinum-containing chemotherapy. In this current study, paclitaxel was found to increase phosphorylation of mitogen-activated protein kinase (MAPK) kinase 3/6 (MKK3/6)-p38 MAPK as well as protein and mRNA levels of ERCC1 in H1650 and H1703 cells. Moreover, paclitaxel-induced ERCC1 protein and mRNA levels significantly decreased via the downregulation of p38 activity by either a p38 MAPK inhibitor SB202190 or p38 knockdown with specific small interfering RNA (siRNA). Specific inhibition of ERCC1 with siRNA was found to enhance the paclitaxel-induced cytotoxic effect and growth inhibition. Furthermore, metformin was able to not only decrease the paclitaxel-induced p38 MAPK-mediated ERCC1 expression, but also augment the cytotoxic effect induced by paclitaxel. Finally, expression of constitutive activate MKK6 or HA-p38 MAPK vectors in lung cancer cells was able to abrogate ERCC1 downregulation by metformin and paclitaxel as well as cell viability and DNA repair capacity. Overall, our results suggest that inhibition of the p38 MAPK signaling by metformin coupled with paclitaxel therapy in human NSCLC cells may be a clinically useful combination, which however will require further validation." @default.
• W2015901914 created "2016-06-24" @default.
• W2015901914 creator A5018293901 @default.
• W2015901914 creator A5024591142 @default.
• W2015901914 creator A5031101659 @default.
• W2015901914 creator A5039887714 @default.
• W2015901914 creator A5045521650 @default.
• W2015901914 creator A5056680093 @default.
• W2015901914 creator A5067312257 @default.
• W2015901914 creator A5080286207 @default.
• W2015901914 date "2013-02-01" @default.
• W2015901914 modified "2023-09-26" @default.
• W2015901914 title "Metformin-mediated downregulation of p38 mitogen-activated protein kinase-dependent excision repair cross-complementing 1 decreases DNA repair capacity and sensitizes human lung cancer cells to paclitaxel" @default.
• W2015901914 cites W1507700358 @default.
• W2015901914 cites W1972152785 @default.
• W2015901914 cites W1974129259 @default.
• W2015901914 cites W1977544523 @default.
• W2015901914 cites W1978901032 @default.
• W2015901914 cites W1983434824 @default.
• W2015901914 cites W1984561337 @default.
• W2015901914 cites W1988339176 @default.
• W2015901914 cites W1990063646 @default.
• W2015901914 cites W1994504180 @default.
• W2015901914 cites W1998129814 @default.
• W2015901914 cites W1998756147 @default.
• W2015901914 cites W2001099356 @default.
• W2015901914 cites W2004718750 @default.
• W2015901914 cites W2007674640 @default.
• W2015901914 cites W2019405732 @default.
• W2015901914 cites W2021481573 @default.
• W2015901914 cites W2026238154 @default.
• W2015901914 cites W2032615620 @default.
• W2015901914 cites W2033304578 @default.
• W2015901914 cites W2036302238 @default.
• W2015901914 cites W2042676891 @default.
• W2015901914 cites W2045441711 @default.
• W2015901914 cites W2051171548 @default.
• W2015901914 cites W2064656431 @default.
• W2015901914 cites W2071496368 @default.
• W2015901914 cites W2074730941 @default.
• W2015901914 cites W2075003503 @default.
• W2015901914 cites W2085463440 @default.
• W2015901914 cites W2089826699 @default.
• W2015901914 cites W2090966736 @default.
• W2015901914 cites W2093664485 @default.
• W2015901914 cites W2100403180 @default.
• W2015901914 cites W2101399403 @default.
• W2015901914 cites W2101995865 @default.
• W2015901914 cites W2113307269 @default.
• W2015901914 cites W2115325946 @default.
• W2015901914 cites W2125292576 @default.
• W2015901914 cites W2125747634 @default.
• W2015901914 cites W2128910004 @default.
• W2015901914 cites W2129318162 @default.
• W2015901914 cites W2145540652 @default.
• W2015901914 cites W2154539063 @default.
• W2015901914 cites W2157000986 @default.
• W2015901914 cites W2165039236 @default.
• W2015901914 cites W2166583179 @default.
• W2015901914 cites W2170956481 @default.
• W2015901914 cites W2171998898 @default.
• W2015901914 cites W2186847038 @default.
• W2015901914 cites W2408284689 @default.
• W2015901914 cites W4255152173 @default.
• W2015901914 doi "https://doi.org/10.1016/j.bcp.2012.12.001" @default.
• W2015901914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23228696" @default.
• W2015901914 hasPublicationYear "2013" @default.
• W2015901914 type Work @default.
• W2015901914 sameAs 2015901914 @default.
• W2015901914 citedByCount "44" @default.
• W2015901914 countsByYear W20159019142012 @default.
• W2015901914 countsByYear W20159019142013 @default.
• W2015901914 countsByYear W20159019142014 @default.
• W2015901914 countsByYear W20159019142015 @default.
• W2015901914 countsByYear W20159019142016 @default.
• W2015901914 countsByYear W20159019142017 @default.
• W2015901914 countsByYear W20159019142018 @default.
• W2015901914 countsByYear W20159019142019 @default.
• W2015901914 countsByYear W20159019142020 @default.
• W2015901914 countsByYear W20159019142021 @default.
• W2015901914 countsByYear W20159019142022 @default.
• W2015901914 countsByYear W20159019142023 @default.
• W2015901914 crossrefType "journal-article" @default.
• W2015901914 hasAuthorship W2015901914A5018293901 @default.
• W2015901914 hasAuthorship W2015901914A5024591142 @default.
• W2015901914 hasAuthorship W2015901914A5031101659 @default.
• W2015901914 hasAuthorship W2015901914A5039887714 @default.
• W2015901914 hasAuthorship W2015901914A5045521650 @default.
• W2015901914 hasAuthorship W2015901914A5056680093 @default.
• W2015901914 hasAuthorship W2015901914A5067312257 @default.
• W2015901914 hasAuthorship W2015901914A5080286207 @default.
• W2015901914 hasConcept C104317684 @default.
• W2015901914 hasConcept C104451858 @default.
• W2015901914 hasConcept C121608353 @default.
• W2015901914 hasConcept C126322002 @default.
• W2015901914 hasConcept C127561419 @default.
• W2015901914 hasConcept C134935766 @default.
• W2015901914 hasConcept C173396325 @default.

• next