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- W2015928690 abstract "We asked whether the neuroprotective effect of cholinergic microglial stimulation during an ischemic event acts via a mechanism involving the activation of nuclear factor erythroid-2-related factor 2 (Nrf2) and/or the expression of its target cytoprotective gene, heme oxygenase-1 (HO-1). Specifically, the protective effect of the pharmacologic alpha-7 nicotinic acetylcholine receptor (α7 nAChR) agonist PNU282987 was analyzed in organotypic hippocampal cultures (OHCs) subjected to oxygen and glucose deprivation (OGD) in vitro as well as in photothrombotic stroke in vivo.OHCs exposed to OGD followed by reoxygenation elicited cell death, measured by propidium iodide and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide staining. Activation of α7 nAChR by PNU282987, after OGD, reduced cell death, reactive oxygen species production, and tumor necrosis factor release. This was associated with induction of HO-1 expression, an effect reversed by α-bungarotoxin and by tin-protoporphyrin IX. The protective effect of PNU282987 was lost in microglial-depleted OHCs as well as in OHCs from Nrf2-deficient-versus-wild-type mice, an effect associated with suppression of HO-1 expression in microglia. Administration of PNU282987 1 h after induction of photothrombotic stroke in vivo reduced the infarct size and improved motor skills in Hmox1(lox/lox) mice that express normal levels of HO-1, but not in LysM(Cre)Hmox1(Δ/Δ) in which HO-1 expression is inhibited in myeloid cells, including the microglia.This study suggests the participation of the microglial α7 nAChR in the brain cholinergic anti-inflammatory pathway.Activation of the α7 nAChR/Nrf2/HO-1 axis in microglia regulates neuroinflammation and oxidative stress, affording neuroprotection under brain ischemic conditions." @default.
- W2015928690 created "2016-06-24" @default.
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- W2015928690 date "2013-10-10" @default.
- W2015928690 modified "2023-10-03" @default.
- W2015928690 title "The Microglial α7-Acetylcholine Nicotinic Receptor Is a Key Element in Promoting Neuroprotection by Inducing Heme Oxygenase-1 <i>via</i> Nuclear Factor Erythroid-2-Related Factor 2" @default.
- W2015928690 cites W1516709032 @default.
- W2015928690 cites W1531336753 @default.
- W2015928690 cites W1595293335 @default.
- W2015928690 cites W1600690434 @default.
- W2015928690 cites W1629179716 @default.
- W2015928690 cites W1967894154 @default.
- W2015928690 cites W1971080924 @default.
- W2015928690 cites W1972534236 @default.
- W2015928690 cites W1976600918 @default.
- W2015928690 cites W1981408589 @default.
- W2015928690 cites W1985240193 @default.
- W2015928690 cites W1991631628 @default.
- W2015928690 cites W1993596487 @default.
- W2015928690 cites W1993765879 @default.
- W2015928690 cites W2001019228 @default.
- W2015928690 cites W2002217214 @default.
- W2015928690 cites W2004349171 @default.
- W2015928690 cites W2011243629 @default.
- W2015928690 cites W2017850724 @default.
- W2015928690 cites W2019070297 @default.
- W2015928690 cites W2026983332 @default.
- W2015928690 cites W2027713233 @default.
- W2015928690 cites W2028778467 @default.
- W2015928690 cites W2029401699 @default.
- W2015928690 cites W2029883168 @default.
- W2015928690 cites W2030908512 @default.
- W2015928690 cites W2036710276 @default.
- W2015928690 cites W2038821144 @default.
- W2015928690 cites W2042013114 @default.
- W2015928690 cites W2045379303 @default.
- W2015928690 cites W2046775696 @default.
- W2015928690 cites W2047482700 @default.
- W2015928690 cites W2048934249 @default.
- W2015928690 cites W2055988844 @default.
- W2015928690 cites W2062145087 @default.
- W2015928690 cites W2062604524 @default.
- W2015928690 cites W2064279995 @default.
- W2015928690 cites W2065278977 @default.
- W2015928690 cites W2065284764 @default.
- W2015928690 cites W2065606007 @default.
- W2015928690 cites W2073295417 @default.
- W2015928690 cites W2075882384 @default.
- W2015928690 cites W2077718567 @default.
- W2015928690 cites W2077767094 @default.
- W2015928690 cites W2079054696 @default.
- W2015928690 cites W2080899229 @default.
- W2015928690 cites W2109218530 @default.
- W2015928690 cites W2109759840 @default.
- W2015928690 cites W2120505405 @default.
- W2015928690 cites W2121418225 @default.
- W2015928690 cites W2132500820 @default.
- W2015928690 cites W2132512088 @default.
- W2015928690 cites W2132608478 @default.
- W2015928690 cites W2141567624 @default.
- W2015928690 cites W2146198846 @default.
- W2015928690 cites W2146336916 @default.
- W2015928690 cites W2146467926 @default.
- W2015928690 cites W2148052253 @default.
- W2015928690 cites W2149059937 @default.
- W2015928690 cites W2150842829 @default.
- W2015928690 cites W2156291518 @default.
- W2015928690 cites W2160251618 @default.
- W2015928690 cites W2161679746 @default.
- W2015928690 cites W2162853795 @default.
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- W2015928690 doi "https://doi.org/10.1089/ars.2012.4671" @default.
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