FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015943542> ?p ?o ?g. }

• W2015943542 endingPage "nrs.04020" @default.
• W2015943542 startingPage "nrs.04020" @default.
• W2015943542 abstract "Thyroid hormone (TH) action is mediated principally through binding of the hormone ligand, 3,3,5-triiodothyronine (T3), to TH receptors (TRs). This hormone-receptor interaction recruits other proteins to form complexes that regulate gene expression by binding to DNA sequences in the promoter of target genes. We recently described an extranuclear mechanism of TH action that consists of the association of TH-liganded TRβ with p85α [regulatory subunit of phosphatidylinositol 3-kinase (PI3K)] in the cytosol and subsequent activation of the PI3K, generating phosphatidylinositol 3,4,5-triphosphate [PtdIns(3,4,5)P3]. This initiates the activation of a signaling cascade by phosphorylation of Akt, mammalian target of rapamycin (mTOR) and its substrate p70S6K, leading to the stimulation of ZAKI-4α synthesis, a calcineurin inhibitor. Furthermore, we found that this same mechanism leads to induction of the transcription factor hypoxia-inducible factor (HIF-1α), and its target genes, glucose transporter (GLUT)1, platelet-type phosphofructokinase (PFKP), and monocarboxylate transporter (MCT) 4. These genes are of special interest, because their products have important roles in cellular glucose metabolism, from glucose uptake (GLUT1) to glycolysis (PFKP) and lactate export (MCT4). These results demonstrate that the TH-TRβ complex can exert a non-genomic action in the cytosol leading to changes in gene expression by direct (HIF-1α) and indirect (ZAKI-4α, GLUT1, PFKP) means." @default.
• W2015943542 created "2016-06-24" @default.
• W2015943542 creator A5003021652 @default.
• W2015943542 creator A5030162924 @default.
• W2015943542 creator A5038183050 @default.
• W2015943542 creator A5046003235 @default.
• W2015943542 creator A5091134822 @default.
• W2015943542 date "2006-01-01" @default.
• W2015943542 modified "2023-10-15" @default.
• W2015943542 title "Thyroid hormone mediated changes in gene expression can be initiated by cytosolic action of the thyroid hormone receptor β through the phosphatidylinositol 3-kinase pathway" @default.
• W2015943542 cites W1661647511 @default.
• W2015943542 cites W1968241038 @default.
• W2015943542 cites W1971460112 @default.
• W2015943542 cites W1978982317 @default.
• W2015943542 cites W1987475341 @default.
• W2015943542 cites W1996573898 @default.
• W2015943542 cites W1999610793 @default.
• W2015943542 cites W2006418305 @default.
• W2015943542 cites W2013880145 @default.
• W2015943542 cites W2039219814 @default.
• W2015943542 cites W2050489252 @default.
• W2015943542 cites W2059389182 @default.
• W2015943542 cites W2060254175 @default.
• W2015943542 cites W2083160145 @default.
• W2015943542 cites W2088134840 @default.
• W2015943542 cites W2093014461 @default.
• W2015943542 cites W2096138350 @default.
• W2015943542 cites W2160166542 @default.
• W2015943542 cites W2167041673 @default.
• W2015943542 doi "https://doi.org/10.1621/nrs.04020" @default.
• W2015943542 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1513074" @default.
• W2015943542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16862226" @default.
• W2015943542 hasPublicationYear "2006" @default.
• W2015943542 type Work @default.
• W2015943542 sameAs 2015943542 @default.
• W2015943542 citedByCount "114" @default.
• W2015943542 countsByYear W20159435422012 @default.
• W2015943542 countsByYear W20159435422013 @default.
• W2015943542 countsByYear W20159435422014 @default.
• W2015943542 countsByYear W20159435422015 @default.
• W2015943542 countsByYear W20159435422016 @default.
• W2015943542 countsByYear W20159435422017 @default.
• W2015943542 countsByYear W20159435422018 @default.
• W2015943542 countsByYear W20159435422019 @default.
• W2015943542 countsByYear W20159435422020 @default.
• W2015943542 countsByYear W20159435422021 @default.
• W2015943542 countsByYear W20159435422022 @default.
• W2015943542 countsByYear W20159435422023 @default.
• W2015943542 crossrefType "journal-article" @default.
• W2015943542 hasAuthorship W2015943542A5003021652 @default.
• W2015943542 hasAuthorship W2015943542A5030162924 @default.
• W2015943542 hasAuthorship W2015943542A5038183050 @default.
• W2015943542 hasAuthorship W2015943542A5046003235 @default.
• W2015943542 hasAuthorship W2015943542A5091134822 @default.
• W2015943542 hasBestOaLocation W20159435421 @default.
• W2015943542 hasConcept C109115496 @default.
• W2015943542 hasConcept C121608353 @default.
• W2015943542 hasConcept C134018914 @default.
• W2015943542 hasConcept C161573976 @default.
• W2015943542 hasConcept C170493617 @default.
• W2015943542 hasConcept C184235292 @default.
• W2015943542 hasConcept C23589133 @default.
• W2015943542 hasConcept C2777952866 @default.
• W2015943542 hasConcept C2778308172 @default.
• W2015943542 hasConcept C2779306644 @default.
• W2015943542 hasConcept C2780610907 @default.
• W2015943542 hasConcept C530470458 @default.
• W2015943542 hasConcept C54355233 @default.
• W2015943542 hasConcept C55493867 @default.
• W2015943542 hasConcept C62478195 @default.
• W2015943542 hasConcept C86554907 @default.
• W2015943542 hasConcept C86803240 @default.
• W2015943542 hasConcept C95444343 @default.
• W2015943542 hasConceptScore W2015943542C109115496 @default.
• W2015943542 hasConceptScore W2015943542C121608353 @default.
• W2015943542 hasConceptScore W2015943542C134018914 @default.
• W2015943542 hasConceptScore W2015943542C161573976 @default.
• W2015943542 hasConceptScore W2015943542C170493617 @default.
• W2015943542 hasConceptScore W2015943542C184235292 @default.
• W2015943542 hasConceptScore W2015943542C23589133 @default.
• W2015943542 hasConceptScore W2015943542C2777952866 @default.
• W2015943542 hasConceptScore W2015943542C2778308172 @default.
• W2015943542 hasConceptScore W2015943542C2779306644 @default.
• W2015943542 hasConceptScore W2015943542C2780610907 @default.
• W2015943542 hasConceptScore W2015943542C530470458 @default.
• W2015943542 hasConceptScore W2015943542C54355233 @default.
• W2015943542 hasConceptScore W2015943542C55493867 @default.
• W2015943542 hasConceptScore W2015943542C62478195 @default.
• W2015943542 hasConceptScore W2015943542C86554907 @default.
• W2015943542 hasConceptScore W2015943542C86803240 @default.
• W2015943542 hasConceptScore W2015943542C95444343 @default.
• W2015943542 hasIssue "1" @default.
• W2015943542 hasLocation W20159435421 @default.
• W2015943542 hasLocation W20159435422 @default.
• W2015943542 hasLocation W20159435423 @default.
• W2015943542 hasLocation W20159435424 @default.
• W2015943542 hasOpenAccess W2015943542 @default.
• W2015943542 hasPrimaryLocation W20159435421 @default.

• next