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• W2015945927 abstract "Abstract Regulatory T (T reg ) cells are indispensable for maintaining peripheral tolerance, whereas T helper (Th)1 and Th17 cells induce inflammation and tissue destruction. Using Foxp3‐GFP knock‐in mice, we report a novel regulatory role for B cell subsets in influencing the differentiation of T reg versus Th1/Th17 cells. Peritoneal B1 cells strongly promoted T cell proliferation and cytokine secretion when presenting nominal or allogeneic antigens, as compared to conventional follicular B (B2) cells. However, peritoneal B1 cells largely failed to convert naive Foxp3 – CD4 + T cells into Foxp3 + T reg cells in the presence of TGF‐β and IL‐2, in marked contrast to conventional B2 cells, which excelled in T reg conversion. Interestingly, under the same T reg conversion conditions, peritoneal B1 cells preferentially promoted Th1 and Th17 cell differentiation. Blockade of CD86 but not CD80 costimulation markedly enhanced T reg cell induction by B1 cells. Thus, B cell antigen presentation function is inversely correlated with de novo T reg cell induction for these B cell subsets. Our findings suggest that B1 and B2 cell subsets play distinct roles in immune regulation by promoting reciprocal differentiation of T cell lineages." @default.
• W2015945927 created "2016-06-24" @default.
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• W2015945927 date "2007-08-27" @default.
• W2015945927 modified "2023-10-13" @default.
• W2015945927 title "Reciprocal generation of Th1/Th17 and Treg cells by B1 and B2 B cells" @default.
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• W2015945927 doi "https://doi.org/10.1002/eji.200737296" @default.
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