Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015953233> ?p ?o ?g. }
- W2015953233 endingPage "318" @default.
- W2015953233 startingPage "312" @default.
- W2015953233 abstract "We sought to clarify pathological features and genetic alterations in colorectal carcinomas with characteristics of nonpolypoid growth. Colorectal carcinomas resected at Showa University Hospital in Tokyo included 86 with characteristics of polypoid growth (PG) and 21 with those of nonpolypoid growth (NPG). Mutations of APC, Ki-ras, and p53 genes, as well as microsatellite instability (MSI), were analysed using fluorescence-based polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP). Carcinomas with an NPG pattern were smaller than PG tumours (P<0.0001). Carcinomas with a PG pattern were more likely to harbour Ki-ras mutations (36%) than NPG tumours (0%; P<0.0001). Mutation types in the APC gene differed significantly between PG and NPG carcinomas (P=0.0189), including frameshift mutations in 66% of PG carcinomas but no NPG carcinomas. Presence of a p53 mutation at a 'hot spot' also was more likely in PG carcinomas (37%) than in NPG carcinomas (0%; P=0.0124). No significant difference in presence of MSI was evident between carcinomas with PG and NPG patterns. In conclusion, significant genetic differences were evident between carcinomas with PG and NPG patterns. Genetic changes in NPG carcinomas differed from those of the conventional adenoma-carcinoma sequence. Assuming that some nonpolypoid growth lesions transform rapidly into advanced carcinomas, 20% of all colorectal carcinomas may progress in this manner." @default.
- W2015953233 created "2016-06-24" @default.
- W2015953233 creator A5006603221 @default.
- W2015953233 creator A5007163549 @default.
- W2015953233 creator A5028538646 @default.
- W2015953233 creator A5032487304 @default.
- W2015953233 creator A5040325241 @default.
- W2015953233 creator A5043631647 @default.
- W2015953233 creator A5049903784 @default.
- W2015953233 creator A5051763064 @default.
- W2015953233 creator A5056102084 @default.
- W2015953233 creator A5060616094 @default.
- W2015953233 creator A5062762785 @default.
- W2015953233 creator A5066662582 @default.
- W2015953233 creator A5069879116 @default.
- W2015953233 creator A5075580885 @default.
- W2015953233 creator A5084274447 @default.
- W2015953233 date "2004-06-22" @default.
- W2015953233 modified "2023-10-09" @default.
- W2015953233 title "Pathological features and genetic alterations in colorectal carcinomas with characteristics of nonpolypoid growth" @default.
- W2015953233 cites W1513040830 @default.
- W2015953233 cites W1552426876 @default.
- W2015953233 cites W1578503276 @default.
- W2015953233 cites W1587370672 @default.
- W2015953233 cites W1668105735 @default.
- W2015953233 cites W1725604608 @default.
- W2015953233 cites W1964753576 @default.
- W2015953233 cites W1973385862 @default.
- W2015953233 cites W1976044987 @default.
- W2015953233 cites W1979618971 @default.
- W2015953233 cites W1996449685 @default.
- W2015953233 cites W2001258296 @default.
- W2015953233 cites W2002629196 @default.
- W2015953233 cites W2003705416 @default.
- W2015953233 cites W2005344674 @default.
- W2015953233 cites W2005701686 @default.
- W2015953233 cites W2006456146 @default.
- W2015953233 cites W2015984612 @default.
- W2015953233 cites W2018348035 @default.
- W2015953233 cites W2031453950 @default.
- W2015953233 cites W2040445699 @default.
- W2015953233 cites W2043539979 @default.
- W2015953233 cites W2045254379 @default.
- W2015953233 cites W2047598466 @default.
- W2015953233 cites W2053186041 @default.
- W2015953233 cites W2053950147 @default.
- W2015953233 cites W2060919145 @default.
- W2015953233 cites W2065045375 @default.
- W2015953233 cites W2065091147 @default.
- W2015953233 cites W2070898102 @default.
- W2015953233 cites W2071697240 @default.
- W2015953233 cites W2075300416 @default.
- W2015953233 cites W2077656576 @default.
- W2015953233 cites W2091689774 @default.
- W2015953233 cites W2091723114 @default.
- W2015953233 cites W2093052192 @default.
- W2015953233 cites W2093531978 @default.
- W2015953233 cites W2096276671 @default.
- W2015953233 cites W2098806657 @default.
- W2015953233 cites W2110920426 @default.
- W2015953233 cites W2122684485 @default.
- W2015953233 cites W2142314313 @default.
- W2015953233 cites W2151838624 @default.
- W2015953233 cites W2154546296 @default.
- W2015953233 cites W2155436463 @default.
- W2015953233 cites W2162701425 @default.
- W2015953233 cites W2163330492 @default.
- W2015953233 cites W2169075760 @default.
- W2015953233 cites W2171080110 @default.
- W2015953233 cites W2283746817 @default.
- W2015953233 cites W2316641459 @default.
- W2015953233 cites W2405173083 @default.
- W2015953233 cites W2470031035 @default.
- W2015953233 cites W4237610859 @default.
- W2015953233 doi "https://doi.org/10.1038/sj.bjc.6601965" @default.
- W2015953233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2409809" @default.
- W2015953233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15213719" @default.
- W2015953233 hasPublicationYear "2004" @default.
- W2015953233 type Work @default.
- W2015953233 sameAs 2015953233 @default.
- W2015953233 citedByCount "12" @default.
- W2015953233 countsByYear W20159532332012 @default.
- W2015953233 countsByYear W20159532332013 @default.
- W2015953233 countsByYear W20159532332018 @default.
- W2015953233 countsByYear W20159532332020 @default.
- W2015953233 countsByYear W20159532332022 @default.
- W2015953233 crossrefType "journal-article" @default.
- W2015953233 hasAuthorship W2015953233A5006603221 @default.
- W2015953233 hasAuthorship W2015953233A5007163549 @default.
- W2015953233 hasAuthorship W2015953233A5028538646 @default.
- W2015953233 hasAuthorship W2015953233A5032487304 @default.
- W2015953233 hasAuthorship W2015953233A5040325241 @default.
- W2015953233 hasAuthorship W2015953233A5043631647 @default.
- W2015953233 hasAuthorship W2015953233A5049903784 @default.
- W2015953233 hasAuthorship W2015953233A5051763064 @default.
- W2015953233 hasAuthorship W2015953233A5056102084 @default.
- W2015953233 hasAuthorship W2015953233A5060616094 @default.
- W2015953233 hasAuthorship W2015953233A5062762785 @default.