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- W2015961312 endingPage "396" @default.
- W2015961312 startingPage "385" @default.
- W2015961312 abstract "There are several issues to be considered to reduce the risk of rejection and minimize side effects associated with liver cell transplantation in chronic liver diseases. The source and the condition of stem cell proliferation and differentiation ex vivo and the transplantation protocols are important safety considerations for cell based therapy. The biochemical and molecular markers are important tools for safety evaluation of different processes of cell expansion and transplantation. Studies show that hepatocytes differentiated from adult and embryonic stem cells exhibit biochemical and metabolic properties resembling mature hepatocytes. Therefore these assays can help to assess the biological and metabolic performance of hepatocytes and progenitor stem cells. The assays also help in testing the contribution of transplanted hepatocytes in improving the repair and function of damaged liver in the recipient. Here we review the biochemical and metabolic markers, which are implicated in evaluation of safety issues of stem cells used for therapeutic purposes in chronic liver diseases and regeneration of damaged liver. We also highlight application of biochemical tests for assessment of liver cell transplantation." @default.
- W2015961312 created "2016-06-24" @default.
- W2015961312 creator A5024971399 @default.
- W2015961312 creator A5058045726 @default.
- W2015961312 date "2012-04-01" @default.
- W2015961312 modified "2023-09-27" @default.
- W2015961312 title "Safety evaluation of stem cells used for clinical cell therapy in chronic liver diseases; with emphasize on biochemical markers" @default.
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