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- W2015963521 abstract "Creatine Monohydrate has been shown to increase strength in studies of young healthy individuals. Because muscle weakness and atrophy are common to neuromuscular disorders, there may be potential therapeutic uses for creatine supplementation in these patients. Therefore, the aim of this study was to randomize Amyotrophic Lateral Sclerosis (ALS) patients to a prospective four week trial comparing daily placebo (P) to 5 grams of creatine monohydrate (CM) to determine alterations in muscular strength and body composition. Using a double-blind, placebo- controlled design, twenty-one ALS patients aged 43–65 years (11 men, 10 women) were randomize to P or CM for 30 days. All patients were sedentary, but ambulatory. Exercise level and dietary habits remained constant throughout the study period. Maximal oxygen uptake was measured on a cycle ergometer (15W/2 min), maximal strength was measured by grip strength and CYBEX II Isokinetic Dynamometer (knee flexion/extension), and indices of body composition as measured by DEXA were assessed at baseline and 30 days. Results indicate no change in VO2Max between P and CM groups. Significant increases (p = 0.026) in hamstring muscle strength were observed within the CM group (8%), but not within the P group. A significant increase (p < 0.0001) in lean body mass occurred in the CM group (1.1%), but not within the P group as measured by DEXA. These findings suggest that 30d of creatine supplementation (5 gm/d) increases muscle mass and improves muscle strength in men and women with neuromuscular disease." @default.
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- W2015963521 date "2001-05-01" @default.
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- W2015963521 title "EFFECTS OF CREATINE ON MUSCULAR STRENGTH AND BODY COMPOSITION AMONG PATIENTS WITH NEUROMUSCULAR DISEASE" @default.
- W2015963521 doi "https://doi.org/10.1097/00005768-200105001-01005" @default.
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