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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015963622> ?p ?o ?g. }

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• W2015963622 abstract "Allosteric inhibition of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase enzyme has recently emerged as a viable strategy toward blocking replication of viral RNA in cell-based systems. We report here 2 series of indole-N-acetamides, bearing physicochemically diverse carboxylic acid replacements, which show potent affinity for the NS5B enzyme with reduced potential for formation of glucuronide conjugates. Preliminary optimization of these series furnished compounds that are potent in the blockade of subgenomic HCV RNA replication in HUH-7 cells." @default.
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• W2015963622 date "2007-09-01" @default.
• W2015963622 modified "2023-09-23" @default.
• W2015963622 title "Development of carboxylic acid replacements in indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase" @default.
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• W2015963622 doi "https://doi.org/10.1016/j.bmcl.2007.06.093" @default.
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