Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015963921> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2015963921 endingPage "232" @default.
- W2015963921 startingPage "225" @default.
- W2015963921 abstract "Peripheral blood recovery after cord blood (CB) transplantation is delayed compared with marrow. Expansion of CB haemopoietic cells has been investigated with the aim of reducing cytopenia following transplantation. Mature cells, post-progenitors, progenitors and long-term culture-initiating cells (LTC-IC) from expansion products may contribute to peripheral blood recovery. We investigated the increase in total nucleated cells, colony-forming cells (CFC), CD34+ cells and LTC-IC by limiting dilution after a 14 day culture of CB CD34+ cells (5 x 10(3)/ml) with SCF, IL-3, IL-6, GM-CSF and G-CSF all at 10 ng/ml. On average, nucleated cells increased 2500-fold, CD34+ cells 39-fold and CFU-GM 49-fold with maintenance of BFU-E. The more primitive LTC-IC expanded on average 2.5-fold but effects on long-term marrow-repopulating cells (LTRC) during culture are unknown. A practical application of in vitro expansion of CB might be to expand a 20% aliquot of a CB donation and infuse the remainder unmanipulated. This could provide a 5- to 7-fold increase in progenitor cells, an estimated 1570-fold increase in post-progenitor cells and maintenance of LTC-IC compared to an untreated donation. Combined with in vivo post-transplant growth factor therapy this could prompt early peripheral blood recovery after CB transplantation, without significant loss of LTC-IC or donor lymphocytes." @default.
- W2015963921 created "2016-06-24" @default.
- W2015963921 creator A5014842740 @default.
- W2015963921 creator A5033094032 @default.
- W2015963921 creator A5050802738 @default.
- W2015963921 creator A5054688113 @default.
- W2015963921 creator A5066133666 @default.
- W2015963921 creator A5069233723 @default.
- W2015963921 date "1998-02-01" @default.
- W2015963921 modified "2023-10-06" @default.
- W2015963921 title "Is in vitro expansion of human cord blood cells clinically relevant?" @default.
- W2015963921 cites W261082544 @default.
- W2015963921 doi "https://doi.org/10.1038/sj.bmt.1701078" @default.
- W2015963921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9489644" @default.
- W2015963921 hasPublicationYear "1998" @default.
- W2015963921 type Work @default.
- W2015963921 sameAs 2015963921 @default.
- W2015963921 citedByCount "32" @default.
- W2015963921 countsByYear W20159639212015 @default.
- W2015963921 crossrefType "journal-article" @default.
- W2015963921 hasAuthorship W2015963921A5014842740 @default.
- W2015963921 hasAuthorship W2015963921A5033094032 @default.
- W2015963921 hasAuthorship W2015963921A5050802738 @default.
- W2015963921 hasAuthorship W2015963921A5054688113 @default.
- W2015963921 hasAuthorship W2015963921A5066133666 @default.
- W2015963921 hasAuthorship W2015963921A5069233723 @default.
- W2015963921 hasBestOaLocation W20159639211 @default.
- W2015963921 hasConcept C10205521 @default.
- W2015963921 hasConcept C109159458 @default.
- W2015963921 hasConcept C126322002 @default.
- W2015963921 hasConcept C16685009 @default.
- W2015963921 hasConcept C201750760 @default.
- W2015963921 hasConcept C203014093 @default.
- W2015963921 hasConcept C2780007613 @default.
- W2015963921 hasConcept C2780366003 @default.
- W2015963921 hasConcept C2780914630 @default.
- W2015963921 hasConcept C28328180 @default.
- W2015963921 hasConcept C2911091166 @default.
- W2015963921 hasConcept C71924100 @default.
- W2015963921 hasConcept C86803240 @default.
- W2015963921 hasConcept C95444343 @default.
- W2015963921 hasConceptScore W2015963921C10205521 @default.
- W2015963921 hasConceptScore W2015963921C109159458 @default.
- W2015963921 hasConceptScore W2015963921C126322002 @default.
- W2015963921 hasConceptScore W2015963921C16685009 @default.
- W2015963921 hasConceptScore W2015963921C201750760 @default.
- W2015963921 hasConceptScore W2015963921C203014093 @default.
- W2015963921 hasConceptScore W2015963921C2780007613 @default.
- W2015963921 hasConceptScore W2015963921C2780366003 @default.
- W2015963921 hasConceptScore W2015963921C2780914630 @default.
- W2015963921 hasConceptScore W2015963921C28328180 @default.
- W2015963921 hasConceptScore W2015963921C2911091166 @default.
- W2015963921 hasConceptScore W2015963921C71924100 @default.
- W2015963921 hasConceptScore W2015963921C86803240 @default.
- W2015963921 hasConceptScore W2015963921C95444343 @default.
- W2015963921 hasIssue "3" @default.
- W2015963921 hasLocation W20159639211 @default.
- W2015963921 hasLocation W20159639212 @default.
- W2015963921 hasOpenAccess W2015963921 @default.
- W2015963921 hasPrimaryLocation W20159639211 @default.
- W2015963921 hasRelatedWork W1812483684 @default.
- W2015963921 hasRelatedWork W1984831932 @default.
- W2015963921 hasRelatedWork W1998228373 @default.
- W2015963921 hasRelatedWork W2044559595 @default.
- W2015963921 hasRelatedWork W2054167115 @default.
- W2015963921 hasRelatedWork W2062256187 @default.
- W2015963921 hasRelatedWork W2097466377 @default.
- W2015963921 hasRelatedWork W2416649916 @default.
- W2015963921 hasRelatedWork W2518614969 @default.
- W2015963921 hasRelatedWork W2734587145 @default.
- W2015963921 hasVolume "21" @default.
- W2015963921 isParatext "false" @default.
- W2015963921 isRetracted "false" @default.
- W2015963921 magId "2015963921" @default.
- W2015963921 workType "article" @default.