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- W2015964215 abstract "The transient receptor potential channel, subfamily V, member 6 (TRPV6), is strongly expressed in advanced prostate cancer and significantly correlates with the Gleason >7 grading, being undetectable in healthy and benign prostate tissues. However, the role of TRPV6 as a highly Ca2+-selective channel in prostate carcinogenesis remains poorly understood. Here, we report that TRPV6 is directly involved in the control of prostate cancer cells proliferation by decreasing the proliferation rate, cell accumulation in the S-phase of cell cycle and proliferating cell nuclear antigen (PCNA) expression. We demonstrate that the Ca2+ uptake into prostate cancer cells is mediated by TRPV6, with the subsequent downstream activation of the transcription factor nuclear factor of activated T-cell. TRPV6- mediated Ca2+ entry is also involved in apoptosis resistance of prostate cancer cells. One of the mechanisms by which TRPV6 regulates apoptosis is related to the translocation of channel to the plasma membrane. We conclude that the upregulation of TRPV6 channel in prostate cancer cells may represent a mechanism for maintaining a higher proliferation rate, increasing cell survival and apoptosis resistance as well." @default.
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- W2015964215 date "2012-01-01" @default.
- W2015964215 modified "2023-10-17" @default.
- W2015964215 title "Oncogenic Potential of TRPV6 Channel in Prostate Cancer" @default.
- W2015964215 doi "https://doi.org/10.1016/j.bpj.2011.11.1879" @default.
- W2015964215 hasPublicationYear "2012" @default.
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