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- W2015964672 endingPage "1246" @default.
- W2015964672 startingPage "1227" @default.
- W2015964672 abstract "Protein tyrosine phosphorylation is a key regulatory process in virtually all aspects of cellular functions. Dysregulation of protein tyrosine phosphorylation is a major cause of human diseases, such as cancers, diabetes, autoimmune disorders, and neurological diseases. Indeed, protein tyrosine phosphorylation-mediated signaling events offer ample therapeutic targets, and drug discovery efforts to date have brought over two dozen kinase inhibitors to the clinic. Accordingly, protein tyrosine phosphatases (PTPs) are considered next-generation drug targets. For instance, PTP1B is a well-known targets of type 2 diabetes and obesity, and recent studies indicate that it is also a promising target for breast cancer. SHP2 is a bona-fide oncoprotein, mutations of which cause juvenile myelomonocytic leukemia, acute myeloid leukemia, and solid tumors. In addition, LYP is strongly associated with type 1 diabetes and many other autoimmune diseases. This review summarizes recent findings on several highly recognized PTP family drug targets, including PTP1B, Src homology phosphotyrosyl phosphatase 2(SHP2), lymphoid-specific tyrosine phosphatase (LYP), CD45, Fas associated phosphatase-1 (FAP-1), striatal enriched tyrosine phosphatases (STEP), mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1), phosphatases of regenerating liver-1 (PRL), low molecular weight PTPs (LMWPTP), and CDC25. Given that there are over 100 family members, we hope this review will serve as a road map for innovative drug discovery targeting PTPs." @default.
- W2015964672 created "2016-06-24" @default.
- W2015964672 creator A5002878271 @default.
- W2015964672 creator A5006367063 @default.
- W2015964672 creator A5063650973 @default.
- W2015964672 creator A5067447937 @default.
- W2015964672 date "2014-09-15" @default.
- W2015964672 modified "2023-10-14" @default.
- W2015964672 title "Protein tyrosine phosphatases as potential therapeutic targets" @default.
- W2015964672 cites W133056582 @default.
- W2015964672 cites W1483839132 @default.
- W2015964672 cites W1485667500 @default.
- W2015964672 cites W1487122816 @default.
- W2015964672 cites W1497274503 @default.
- W2015964672 cites W1498892177 @default.
- W2015964672 cites W149894293 @default.
- W2015964672 cites W1522300421 @default.
- W2015964672 cites W1542264887 @default.
- W2015964672 cites W1548747789 @default.
- W2015964672 cites W1552451078 @default.
- W2015964672 cites W1561726217 @default.
- W2015964672 cites W1576593419 @default.
- W2015964672 cites W1577373236 @default.
- W2015964672 cites W159040755 @default.
- W2015964672 cites W1616343296 @default.
- W2015964672 cites W163644054 @default.
- W2015964672 cites W1653069047 @default.
- W2015964672 cites W1656644461 @default.
- W2015964672 cites W1727290854 @default.
- W2015964672 cites W1830301026 @default.
- W2015964672 cites W1832328879 @default.
- W2015964672 cites W1911955404 @default.
- W2015964672 cites W1925896202 @default.
- W2015964672 cites W1960824264 @default.
- W2015964672 cites W1964504843 @default.
- W2015964672 cites W1964595914 @default.
- W2015964672 cites W1965909642 @default.
- W2015964672 cites W1966285532 @default.
- W2015964672 cites W1967818518 @default.
- W2015964672 cites W1968472053 @default.
- W2015964672 cites W1968682237 @default.
- W2015964672 cites W1969918683 @default.
- W2015964672 cites W1970265757 @default.
- W2015964672 cites W1970770376 @default.
- W2015964672 cites W1972985325 @default.
- W2015964672 cites W1973173778 @default.
- W2015964672 cites W1973854677 @default.
- W2015964672 cites W1974357851 @default.
- W2015964672 cites W1975225648 @default.
- W2015964672 cites W1975327945 @default.
- W2015964672 cites W1975746476 @default.
- W2015964672 cites W1976324983 @default.
- W2015964672 cites W1979069875 @default.
- W2015964672 cites W1980360982 @default.
- W2015964672 cites W1980750700 @default.
- W2015964672 cites W1981673694 @default.
- W2015964672 cites W1982020336 @default.
- W2015964672 cites W1983778842 @default.
- W2015964672 cites W1983831457 @default.
- W2015964672 cites W1985368964 @default.
- W2015964672 cites W1985627474 @default.
- W2015964672 cites W1987104712 @default.
- W2015964672 cites W1987114890 @default.
- W2015964672 cites W1987677365 @default.
- W2015964672 cites W1989031138 @default.
- W2015964672 cites W1989535960 @default.
- W2015964672 cites W1990678679 @default.
- W2015964672 cites W1990830210 @default.
- W2015964672 cites W1991449336 @default.
- W2015964672 cites W1992395108 @default.
- W2015964672 cites W1994402720 @default.
- W2015964672 cites W1995088117 @default.
- W2015964672 cites W1996965392 @default.
- W2015964672 cites W1998829285 @default.
- W2015964672 cites W1999046674 @default.
- W2015964672 cites W1999686120 @default.
- W2015964672 cites W2000813775 @default.
- W2015964672 cites W2002083647 @default.
- W2015964672 cites W2003975612 @default.
- W2015964672 cites W2005076200 @default.
- W2015964672 cites W2005955483 @default.
- W2015964672 cites W2006626832 @default.
- W2015964672 cites W2007555056 @default.
- W2015964672 cites W2008574867 @default.
- W2015964672 cites W2008649874 @default.
- W2015964672 cites W2010500827 @default.
- W2015964672 cites W2010959859 @default.
- W2015964672 cites W2011398963 @default.
- W2015964672 cites W2011417333 @default.
- W2015964672 cites W2011736622 @default.
- W2015964672 cites W2013411499 @default.
- W2015964672 cites W2013421761 @default.
- W2015964672 cites W2013438353 @default.
- W2015964672 cites W2013480667 @default.
- W2015964672 cites W2013594457 @default.
- W2015964672 cites W2014129040 @default.
- W2015964672 cites W2014574326 @default.
- W2015964672 cites W2015333169 @default.