FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015965640> ?p ?o ?g. }

• W2015965640 endingPage "423" @default.
• W2015965640 startingPage "414" @default.
• W2015965640 abstract "The angiotensin-converting enzymes (ACE) are involved in the regulation of the specific maturation or degradation of a number of mammalian bioactive peptides. A carboxydipeptidase similar to mammalian ACE has now been identified in the adult stage of the haematophagous fly, Haematobia irritans exigua (buffalo fly), a close relative of the horn fly of North America. The enzyme was purified by lectin-affinity chromatography and ion-exchange chromatography and migrated as a doublet of 70 kDa upon reducing SDS/PAGE. Unlike mammalian ACE, the fly carboxydipeptidase (HieACE) is not membrane bound. The amino acid sequence of an internal peptide from HieACE and a conserved amino acid region present in all mammalian ACE were used to design degenerate oligonucleotide primers suitable for PCR. A DNA fragment amplified from adult buffalo fly cDNA was used to identify a cDNA clone that encoded the enzyme. The cDNA sequence encodes a carboxydipeptidase with 41–42% amino acid identity to the mammalian testicular ACE. The active-site regions of mammalian ACE are conserved in the deduced amino acid sequence of HieACE. Enzymatically, HieACE is very similar to its mammalian counterparts, with comparable Km and Vmax values for the synthetic substrate, benzoylglycylglycylglycine, and similar patterns of inhibition by EDTA, ACE inhibitor peptide and captopril. HieACE also specifically activates angiotensin I to angiotensin II and degrades other mammalian ACE substrates such as bradykinin, substance P and cholecystokinin-8. In the adult fly, HieACE is expressed in the compound ganglion and in the posterior region of the midgut. Similar to the mammalian system, expression of this enzyme is induced in the maturing male reproductive system, which suggests conservation of ACE function in these species." @default.
• W2015965640 created "2016-06-24" @default.
• W2015965640 creator A5014920600 @default.
• W2015965640 creator A5018947225 @default.
• W2015965640 creator A5029415401 @default.
• W2015965640 creator A5030460723 @default.
• W2015965640 creator A5046229868 @default.
• W2015965640 creator A5047159619 @default.
• W2015965640 creator A5066650593 @default.
• W2015965640 date "1996-04-15" @default.
• W2015965640 modified "2023-10-14" @default.
• W2015965640 title "Cloning and Characterisation of Angiotensin-Converting Enzyme from the Dipteran Species, Haematobia irritans exigua, and Its Expression in the Maturing Male Reproductive System" @default.
• W2015965640 cites W120943192 @default.
• W2015965640 cites W142262548 @default.
• W2015965640 cites W1495074957 @default.
• W2015965640 cites W1519205051 @default.
• W2015965640 cites W1527049741 @default.
• W2015965640 cites W1553543142 @default.
• W2015965640 cites W1767994247 @default.
• W2015965640 cites W1949772429 @default.
• W2015965640 cites W1956868294 @default.
• W2015965640 cites W1965286844 @default.
• W2015965640 cites W1968494270 @default.
• W2015965640 cites W1979445128 @default.
• W2015965640 cites W1987452330 @default.
• W2015965640 cites W1988814356 @default.
• W2015965640 cites W1992351338 @default.
• W2015965640 cites W1993532190 @default.
• W2015965640 cites W1993875068 @default.
• W2015965640 cites W1996052952 @default.
• W2015965640 cites W1996526518 @default.
• W2015965640 cites W2000314850 @default.
• W2015965640 cites W2009233266 @default.
• W2015965640 cites W2020435403 @default.
• W2015965640 cites W2024557874 @default.
• W2015965640 cites W2025502113 @default.
• W2015965640 cites W2026921577 @default.
• W2015965640 cites W2038547150 @default.
• W2015965640 cites W2051332153 @default.
• W2015965640 cites W2054794915 @default.
• W2015965640 cites W2056087565 @default.
• W2015965640 cites W2056435519 @default.
• W2015965640 cites W2062738447 @default.
• W2015965640 cites W2067165584 @default.
• W2015965640 cites W2067763402 @default.
• W2015965640 cites W2067822763 @default.
• W2015965640 cites W2077143473 @default.
• W2015965640 cites W2078541862 @default.
• W2015965640 cites W2084800579 @default.
• W2015965640 cites W2085033969 @default.
• W2015965640 cites W2092286842 @default.
• W2015965640 cites W2139851406 @default.
• W2015965640 cites W2159206824 @default.
• W2015965640 cites W2163398157 @default.
• W2015965640 cites W2175228938 @default.
• W2015965640 cites W2410790297 @default.
• W2015965640 cites W4236236547 @default.
• W2015965640 doi "https://doi.org/10.1111/j.1432-1033.1996.0414k.x" @default.
• W2015965640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8647080" @default.
• W2015965640 hasPublicationYear "1996" @default.
• W2015965640 type Work @default.
• W2015965640 sameAs 2015965640 @default.
• W2015965640 citedByCount "57" @default.
• W2015965640 countsByYear W20159656402012 @default.
• W2015965640 countsByYear W20159656402013 @default.
• W2015965640 countsByYear W20159656402014 @default.
• W2015965640 countsByYear W20159656402015 @default.
• W2015965640 countsByYear W20159656402016 @default.
• W2015965640 countsByYear W20159656402017 @default.
• W2015965640 countsByYear W20159656402019 @default.
• W2015965640 countsByYear W20159656402022 @default.
• W2015965640 crossrefType "journal-article" @default.
• W2015965640 hasAuthorship W2015965640A5014920600 @default.
• W2015965640 hasAuthorship W2015965640A5018947225 @default.
• W2015965640 hasAuthorship W2015965640A5029415401 @default.
• W2015965640 hasAuthorship W2015965640A5030460723 @default.
• W2015965640 hasAuthorship W2015965640A5046229868 @default.
• W2015965640 hasAuthorship W2015965640A5047159619 @default.
• W2015965640 hasAuthorship W2015965640A5066650593 @default.
• W2015965640 hasConcept C104317684 @default.
• W2015965640 hasConcept C134018914 @default.
• W2015965640 hasConcept C153911025 @default.
• W2015965640 hasConcept C167625842 @default.
• W2015965640 hasConcept C187882448 @default.
• W2015965640 hasConcept C18903297 @default.
• W2015965640 hasConcept C27016395 @default.
• W2015965640 hasConcept C2777707652 @default.
• W2015965640 hasConcept C2778369456 @default.
• W2015965640 hasConcept C2780039072 @default.
• W2015965640 hasConcept C515207424 @default.
• W2015965640 hasConcept C55493867 @default.
• W2015965640 hasConcept C84393581 @default.
• W2015965640 hasConcept C86803240 @default.
• W2015965640 hasConceptScore W2015965640C104317684 @default.
• W2015965640 hasConceptScore W2015965640C134018914 @default.
• W2015965640 hasConceptScore W2015965640C153911025 @default.
• W2015965640 hasConceptScore W2015965640C167625842 @default.
• W2015965640 hasConceptScore W2015965640C187882448 @default.

• next