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- W2015971103 abstract "Stimulation of periaqueductal gray sites resulted in both increased latencies to escape heated water with a tail-flick and audible vocalizations. To determine whether these two responses were the result of stimulation of the same substrates, refractory periods were estimated by delivering paired-pulse trains of stimulation. Stimulation consisted of 10 or 20 s trains of single pulses or pulse pairs. The pulse pair frequency threshold for both behaviors was determined for intra-pulse (C-T) intervals of 0.4–10 ms. The ratio of single to double pulse frequency thresholds provided an indication of relative effectiveness of the paired-pulse stimulation. For analgesia, the paired-pulse effectiveness gradually increased between C-T intervals of 2.0 and 5.0 ms, after which asymptotic effectiveness values were obtained. Thus, the estimated refractory period for analgesia was 2.0–5.0 ms. The refractory period estimate for vocalizations was shorter. Effectiveness values increased with a C-T interval of 1.2 ms and reached asymptote with a C-T interval of 2.0 ms. These results suggest that different fibers with overlapping spatial distributions contribute to analgesia and vocalizations produced by midbrain stimulation." @default.
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- W2015971103 title "Differentiation of the substrates for analgesia and vocalizations elicited by midbrain stimulation in rats: Refractory period estimates" @default.
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- W2015971103 doi "https://doi.org/10.1016/0166-4328(88)90012-5" @default.
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