FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015985945> ?p ?o ?g. }

• W2015985945 endingPage "184" @default.
• W2015985945 startingPage "179" @default.
• W2015985945 abstract "Objectives E-cadherin and β-catenin are adhesion molecules responsible for the maintenance of normal epithelial cell phenotype. A disturbance in epithelial cell adhesion, which leads to a more invasive and metastatic phenotype, is a hallmark of tumor progression. Several immunohistochemical studies have reported a strong correlation between loss of their expression to higher stage and grade in prostate carcinoma, but their influence in metastatic process is not yet known. The aim of this study is to verify the role of adhesion molecules in the progression of prostate cancer (PC), assessing the expression of E-cadherin and β-catenin in bone metastasis. Materials and Methods Twenty-eight bone metastases of prostate carcinoma were submitted to immunohistochemistry analysis for E-cadherin and β-catenin expression. In 6 patients, we were able to assess the expression of the adhesion molecules in the primary tumors and their respective metastases. The definition of normal expression for both antibodies was strong and diffuse expression in more than 70% of tumor cells. Results In bone metastases, there was loss of expression of E-cadherin and β-catenin in 86% and 82%, respectively. Among the primary tumors, E-cadherin and β-catenin expression was normal in 83% and 50% cases, respectively. Considering the 6 patients with paired primary and bone metastasis, we found loss of expression for both E-cadherin and β-catenin in most of the cases. Conclusions Comparing primary PC and its metastasis, we showed persistent loss of E-cadherin and β-catenin expression. This phenomenon may be related to metastatic potential in PC, because we have shown underexpression for E-cadherin and β-catenin in 86% and 82% of bone metastases." @default.
• W2015985945 created "2016-06-24" @default.
• W2015985945 creator A5008066734 @default.
• W2015985945 creator A5015268271 @default.
• W2015985945 creator A5025924020 @default.
• W2015985945 creator A5040525868 @default.
• W2015985945 creator A5054445751 @default.
• W2015985945 creator A5066775756 @default.
• W2015985945 date "2010-03-01" @default.
• W2015985945 modified "2023-10-16" @default.
• W2015985945 title "E-cadherin and β-catenin Loss of Expression Related to Bone Metastasis in Prostate Cancer" @default.
• W2015985945 cites W1496143836 @default.
• W2015985945 cites W1553431928 @default.
• W2015985945 cites W1974712385 @default.
• W2015985945 cites W1975159611 @default.
• W2015985945 cites W1978740715 @default.
• W2015985945 cites W1980637945 @default.
• W2015985945 cites W1985841620 @default.
• W2015985945 cites W1992608118 @default.
• W2015985945 cites W1993016991 @default.
• W2015985945 cites W2004408232 @default.
• W2015985945 cites W2006502722 @default.
• W2015985945 cites W2010467196 @default.
• W2015985945 cites W2018884883 @default.
• W2015985945 cites W2019622223 @default.
• W2015985945 cites W2028124085 @default.
• W2015985945 cites W2044062209 @default.
• W2015985945 cites W2067747936 @default.
• W2015985945 cites W2073537069 @default.
• W2015985945 cites W2083073815 @default.
• W2015985945 cites W2108360007 @default.
• W2015985945 cites W2108793493 @default.
• W2015985945 cites W2122519439 @default.
• W2015985945 cites W2130837149 @default.
• W2015985945 cites W2135331851 @default.
• W2015985945 cites W2141287999 @default.
• W2015985945 cites W2397842152 @default.
• W2015985945 doi "https://doi.org/10.1097/pai.0b013e3181640bca" @default.
• W2015985945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18685493" @default.
• W2015985945 hasPublicationYear "2010" @default.
• W2015985945 type Work @default.
• W2015985945 sameAs 2015985945 @default.
• W2015985945 citedByCount "32" @default.
• W2015985945 countsByYear W20159859452012 @default.
• W2015985945 countsByYear W20159859452013 @default.
• W2015985945 countsByYear W20159859452014 @default.
• W2015985945 countsByYear W20159859452015 @default.
• W2015985945 countsByYear W20159859452016 @default.
• W2015985945 countsByYear W20159859452017 @default.
• W2015985945 countsByYear W20159859452018 @default.
• W2015985945 countsByYear W20159859452019 @default.
• W2015985945 countsByYear W20159859452020 @default.
• W2015985945 crossrefType "journal-article" @default.
• W2015985945 hasAuthorship W2015985945A5008066734 @default.
• W2015985945 hasAuthorship W2015985945A5015268271 @default.
• W2015985945 hasAuthorship W2015985945A5025924020 @default.
• W2015985945 hasAuthorship W2015985945A5040525868 @default.
• W2015985945 hasAuthorship W2015985945A5054445751 @default.
• W2015985945 hasAuthorship W2015985945A5066775756 @default.
• W2015985945 hasConcept C121608353 @default.
• W2015985945 hasConcept C126322002 @default.
• W2015985945 hasConcept C137620995 @default.
• W2015985945 hasConcept C142724271 @default.
• W2015985945 hasConcept C1491633281 @default.
• W2015985945 hasConcept C149402561 @default.
• W2015985945 hasConcept C16224149 @default.
• W2015985945 hasConcept C203014093 @default.
• W2015985945 hasConcept C204232928 @default.
• W2015985945 hasConcept C2776235491 @default.
• W2015985945 hasConcept C2777783956 @default.
• W2015985945 hasConcept C2779013556 @default.
• W2015985945 hasConcept C2780192828 @default.
• W2015985945 hasConcept C2780283643 @default.
• W2015985945 hasConcept C30145163 @default.
• W2015985945 hasConcept C502942594 @default.
• W2015985945 hasConcept C54355233 @default.
• W2015985945 hasConcept C55493867 @default.
• W2015985945 hasConcept C62478195 @default.
• W2015985945 hasConcept C71924100 @default.
• W2015985945 hasConcept C86803240 @default.
• W2015985945 hasConceptScore W2015985945C121608353 @default.
• W2015985945 hasConceptScore W2015985945C126322002 @default.
• W2015985945 hasConceptScore W2015985945C137620995 @default.
• W2015985945 hasConceptScore W2015985945C142724271 @default.
• W2015985945 hasConceptScore W2015985945C1491633281 @default.
• W2015985945 hasConceptScore W2015985945C149402561 @default.
• W2015985945 hasConceptScore W2015985945C16224149 @default.
• W2015985945 hasConceptScore W2015985945C203014093 @default.
• W2015985945 hasConceptScore W2015985945C204232928 @default.
• W2015985945 hasConceptScore W2015985945C2776235491 @default.
• W2015985945 hasConceptScore W2015985945C2777783956 @default.
• W2015985945 hasConceptScore W2015985945C2779013556 @default.
• W2015985945 hasConceptScore W2015985945C2780192828 @default.
• W2015985945 hasConceptScore W2015985945C2780283643 @default.
• W2015985945 hasConceptScore W2015985945C30145163 @default.
• W2015985945 hasConceptScore W2015985945C502942594 @default.
• W2015985945 hasConceptScore W2015985945C54355233 @default.
• W2015985945 hasConceptScore W2015985945C55493867 @default.

• next