Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015986978> ?p ?o ?g. }
- W2015986978 endingPage "676" @default.
- W2015986978 startingPage "670" @default.
- W2015986978 abstract "Abstract Spreading of melanoma is associated with efficient extravasation of circulating tumor cells from the vascular system into distant target organs. This process is accompanied and supported by proinflammatory and procoagulatory conditions. In this study, we analysed the ability of human melanoma cell lines to activate endothelial cells ( EC s) in vitro . Some melanoma cells, that is, MV 3, were shown to trigger an prompt calcium‐flux‐dependent, procoagulatory endothelial response that was accompanied by luminal release of ultra‐large von Willebrand factor ( ULVWF ) fibres that were immobilized to the endothelial surface layer. In contrast to MV 3‐derived supernatant, prolonged treatment of EC s with WM 9‐derived supernatant mediated a pronounced activation of nuclear factor kappa B ( NF κ B). NF κ B activation in EC s was dependent on both IL ‐1 α and IL ‐1 β secreted from melanoma cells. Melanoma‐derived IL ‐1 mediated an upregulation of proinflammatory cytokines IL ‐6 and IL ‐8, the intercellular adhesion molecule‐1 ( ICAM ‐1), the vascular cell adhesion molecule‐1 ( VCAM ‐1) and the procoagulatory tissue factor ( TF ) in EC s. Our data show that melanoma cells activate EC s either directly and within seconds or by an IL ‐1‐mediated NF κ B activation. Both pathways of EC activation convert the regular repressive function of EC s on inflammation and coagulation to a proinflammatory and procoagulatory surface that supports tumor progression." @default.
- W2015986978 created "2016-06-24" @default.
- W2015986978 creator A5005226020 @default.
- W2015986978 creator A5031674227 @default.
- W2015986978 creator A5043495084 @default.
- W2015986978 creator A5058105947 @default.
- W2015986978 creator A5072806793 @default.
- W2015986978 creator A5086051455 @default.
- W2015986978 creator A5086771258 @default.
- W2015986978 date "2014-09-01" @default.
- W2015986978 modified "2023-10-09" @default.
- W2015986978 title "Melanoma‐derived <scp>IL</scp>‐1 converts vascular endothelium to a proinflammatory and procoagulatory phenotype via <scp>NF</scp><i>κ</i>B activation" @default.
- W2015986978 cites W1547515123 @default.
- W2015986978 cites W1951152790 @default.
- W2015986978 cites W1963494914 @default.
- W2015986978 cites W1975073476 @default.
- W2015986978 cites W1987133730 @default.
- W2015986978 cites W1993192315 @default.
- W2015986978 cites W1996150072 @default.
- W2015986978 cites W1997454000 @default.
- W2015986978 cites W2000673564 @default.
- W2015986978 cites W2000677615 @default.
- W2015986978 cites W2002445713 @default.
- W2015986978 cites W2005278507 @default.
- W2015986978 cites W2012718436 @default.
- W2015986978 cites W2014951035 @default.
- W2015986978 cites W2015331990 @default.
- W2015986978 cites W2018038784 @default.
- W2015986978 cites W2018556348 @default.
- W2015986978 cites W2020357852 @default.
- W2015986978 cites W2022788095 @default.
- W2015986978 cites W2029221777 @default.
- W2015986978 cites W2034992352 @default.
- W2015986978 cites W2035234209 @default.
- W2015986978 cites W2052418612 @default.
- W2015986978 cites W2059776541 @default.
- W2015986978 cites W2064597980 @default.
- W2015986978 cites W2068516100 @default.
- W2015986978 cites W2069766968 @default.
- W2015986978 cites W2072063413 @default.
- W2015986978 cites W2080811414 @default.
- W2015986978 cites W2081527131 @default.
- W2015986978 cites W2082815729 @default.
- W2015986978 cites W2083071223 @default.
- W2015986978 cites W2087984134 @default.
- W2015986978 cites W2089996797 @default.
- W2015986978 cites W2093330684 @default.
- W2015986978 cites W2093456571 @default.
- W2015986978 cites W2097995306 @default.
- W2015986978 cites W2098076634 @default.
- W2015986978 cites W2105672169 @default.
- W2015986978 cites W2105706735 @default.
- W2015986978 cites W2111405574 @default.
- W2015986978 cites W2114604545 @default.
- W2015986978 cites W2120929800 @default.
- W2015986978 cites W2124551895 @default.
- W2015986978 cites W2128273788 @default.
- W2015986978 cites W2137728993 @default.
- W2015986978 cites W2138321048 @default.
- W2015986978 cites W2138876537 @default.
- W2015986978 cites W2142160537 @default.
- W2015986978 cites W2143580209 @default.
- W2015986978 cites W2152425711 @default.
- W2015986978 cites W2152854706 @default.
- W2015986978 cites W2162300976 @default.
- W2015986978 cites W2170462247 @default.
- W2015986978 cites W2171003020 @default.
- W2015986978 cites W3134253202 @default.
- W2015986978 cites W4244068819 @default.
- W2015986978 cites W4246434552 @default.
- W2015986978 doi "https://doi.org/10.1111/exd.12505" @default.
- W2015986978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25041487" @default.
- W2015986978 hasPublicationYear "2014" @default.
- W2015986978 type Work @default.
- W2015986978 sameAs 2015986978 @default.
- W2015986978 citedByCount "21" @default.
- W2015986978 countsByYear W20159869782015 @default.
- W2015986978 countsByYear W20159869782017 @default.
- W2015986978 countsByYear W20159869782018 @default.
- W2015986978 countsByYear W20159869782019 @default.
- W2015986978 countsByYear W20159869782020 @default.
- W2015986978 countsByYear W20159869782021 @default.
- W2015986978 countsByYear W20159869782022 @default.
- W2015986978 countsByYear W20159869782023 @default.
- W2015986978 crossrefType "journal-article" @default.
- W2015986978 hasAuthorship W2015986978A5005226020 @default.
- W2015986978 hasAuthorship W2015986978A5031674227 @default.
- W2015986978 hasAuthorship W2015986978A5043495084 @default.
- W2015986978 hasAuthorship W2015986978A5058105947 @default.
- W2015986978 hasAuthorship W2015986978A5072806793 @default.
- W2015986978 hasAuthorship W2015986978A5086051455 @default.
- W2015986978 hasAuthorship W2015986978A5086771258 @default.
- W2015986978 hasConcept C104317684 @default.
- W2015986978 hasConcept C123012128 @default.
- W2015986978 hasConcept C126322002 @default.
- W2015986978 hasConcept C127561419 @default.
- W2015986978 hasConcept C134018914 @default.
- W2015986978 hasConcept C16224149 @default.