Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015990950> ?p ?o ?g. }
- W2015990950 endingPage "6053" @default.
- W2015990950 startingPage "6033" @default.
- W2015990950 abstract "Alzheimer’s disease (AD) is associated with impaired Aβ degradation in the brain. Enhancing the process of Aβ clearance is an attractive potential AD therapy. Treatment with LXR agonists may reduce Aβ levels in vivo. However, the clinical potential of many LXR agonists is limited because of their nonselective actions on LXRα/β, which lead to undesired hepatic lipogenesis via LXRα-dependent pathways. In this study, ABCA1 up-regulators were identified from a series of flavonoids and were found to preferentially activate LXRβ and up-regulate expression of ABCA1 and apoE in different cell lines. Further investigations confirmed that these compounds facilitate intracellular Aβ clearance in Aβ-loaded BV2 cells. Administration of compound 19 reduced total brain Aβ and plaque burden in APP/PS1 double transgenic mice, associated with elevated ABCA1 and apoE expression. Compared with the nonselective LXR agonists, the active compounds reported here induced less accumulation of undesired lipids and triglycerides in HepG2 cells." @default.
- W2015990950 created "2016-06-24" @default.
- W2015990950 creator A5006925784 @default.
- W2015990950 creator A5007847855 @default.
- W2015990950 creator A5008517264 @default.
- W2015990950 creator A5014253943 @default.
- W2015990950 creator A5019928568 @default.
- W2015990950 creator A5020491242 @default.
- W2015990950 creator A5025473895 @default.
- W2015990950 creator A5036418469 @default.
- W2015990950 creator A5052511466 @default.
- W2015990950 creator A5058814917 @default.
- W2015990950 creator A5069797266 @default.
- W2015990950 creator A5074513416 @default.
- W2015990950 creator A5089135718 @default.
- W2015990950 date "2013-07-26" @default.
- W2015990950 modified "2023-09-26" @default.
- W2015990950 title "Synthesis and Identification of New Flavonoids Targeting Liver X Receptor β Involved Pathway as Potential Facilitators of Aβ Clearance with Reduced Lipid Accumulation" @default.
- W2015990950 cites W1570388980 @default.
- W2015990950 cites W1616122655 @default.
- W2015990950 cites W1947043095 @default.
- W2015990950 cites W1974878596 @default.
- W2015990950 cites W1977646332 @default.
- W2015990950 cites W1978907821 @default.
- W2015990950 cites W1979983012 @default.
- W2015990950 cites W1985721648 @default.
- W2015990950 cites W1989076425 @default.
- W2015990950 cites W1991166529 @default.
- W2015990950 cites W1992544262 @default.
- W2015990950 cites W1994554610 @default.
- W2015990950 cites W1995975927 @default.
- W2015990950 cites W1996457468 @default.
- W2015990950 cites W1997859594 @default.
- W2015990950 cites W1998208719 @default.
- W2015990950 cites W2000673403 @default.
- W2015990950 cites W2004324219 @default.
- W2015990950 cites W2010271481 @default.
- W2015990950 cites W2012716588 @default.
- W2015990950 cites W2013111251 @default.
- W2015990950 cites W2014400440 @default.
- W2015990950 cites W2016676112 @default.
- W2015990950 cites W2029427029 @default.
- W2015990950 cites W2030442022 @default.
- W2015990950 cites W2033354781 @default.
- W2015990950 cites W2034522338 @default.
- W2015990950 cites W2037427678 @default.
- W2015990950 cites W2039999716 @default.
- W2015990950 cites W2046658442 @default.
- W2015990950 cites W2046847750 @default.
- W2015990950 cites W2048100774 @default.
- W2015990950 cites W2053715303 @default.
- W2015990950 cites W2054594146 @default.
- W2015990950 cites W2059256286 @default.
- W2015990950 cites W2067450395 @default.
- W2015990950 cites W2069121057 @default.
- W2015990950 cites W2069275980 @default.
- W2015990950 cites W2070030133 @default.
- W2015990950 cites W2081388499 @default.
- W2015990950 cites W2096410114 @default.
- W2015990950 cites W2105761603 @default.
- W2015990950 cites W2112003179 @default.
- W2015990950 cites W2117639596 @default.
- W2015990950 cites W2124927590 @default.
- W2015990950 cites W2127104460 @default.
- W2015990950 cites W2128660079 @default.
- W2015990950 cites W2130728151 @default.
- W2015990950 cites W2131819352 @default.
- W2015990950 cites W2142943752 @default.
- W2015990950 cites W2165373090 @default.
- W2015990950 cites W2168023477 @default.
- W2015990950 doi "https://doi.org/10.1021/jm301913k" @default.
- W2015990950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23844653" @default.
- W2015990950 hasPublicationYear "2013" @default.
- W2015990950 type Work @default.
- W2015990950 sameAs 2015990950 @default.
- W2015990950 citedByCount "17" @default.
- W2015990950 countsByYear W20159909502014 @default.
- W2015990950 countsByYear W20159909502015 @default.
- W2015990950 countsByYear W20159909502016 @default.
- W2015990950 countsByYear W20159909502017 @default.
- W2015990950 countsByYear W20159909502018 @default.
- W2015990950 countsByYear W20159909502019 @default.
- W2015990950 countsByYear W20159909502020 @default.
- W2015990950 countsByYear W20159909502022 @default.
- W2015990950 crossrefType "journal-article" @default.
- W2015990950 hasAuthorship W2015990950A5006925784 @default.
- W2015990950 hasAuthorship W2015990950A5007847855 @default.
- W2015990950 hasAuthorship W2015990950A5008517264 @default.
- W2015990950 hasAuthorship W2015990950A5014253943 @default.
- W2015990950 hasAuthorship W2015990950A5019928568 @default.
- W2015990950 hasAuthorship W2015990950A5020491242 @default.
- W2015990950 hasAuthorship W2015990950A5025473895 @default.
- W2015990950 hasAuthorship W2015990950A5036418469 @default.
- W2015990950 hasAuthorship W2015990950A5052511466 @default.
- W2015990950 hasAuthorship W2015990950A5058814917 @default.
- W2015990950 hasAuthorship W2015990950A5069797266 @default.
- W2015990950 hasAuthorship W2015990950A5074513416 @default.
- W2015990950 hasAuthorship W2015990950A5089135718 @default.