Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015995382> ?p ?o ?g. }
- W2015995382 endingPage "150" @default.
- W2015995382 startingPage "133" @default.
- W2015995382 abstract "This paper updates an early review on benzodiazepine-enhanced food intake, published in the first issue of Appetite, and describes the considerable advances since then in the pharmacology of benzodiazepines, their sites and mechanisms of action, and in understanding the psychological processes leading to the increase in food consumption. A great diversity of benzodiazepine receptor ligands have been developed, many of which affect food intake. Agonists can be divided into full agonists (which produce the full spectrum of benzodiazepine effects) and partial agonists (which are more selective in their effects). In addition, inverse agonists have been identified, with high affinity for benzodiazepine receptors but having negative efficacy: these drugs exhibit anorectic properties. Benzodiazepine receptors are part of GABA(A) receptor complexes, and ligands thereby modulate inhibitory neurotransmission in the brain. Molecular approaches have identified a palette of receptor subunits from which GABA(A) receptors are assembled. In all likelihood, benzodiazepine-induced hyperphagia is mediated by the alpha2/alpha3 subtype not the alpha1 subtype. Novel alpha2/alpha3 selective compounds will test this hypothesis. A probable site of action in the caudal brainstem for benzodiazepines is the parabrachial nucleus. Behavioural evidence strongly indicates that a primary action of benzodiazepines is to enhance the positive hedonic evaluation (palatability) of tastes and foodstuffs. This generates the increased food intake and instrumental responding for food rewards. Therapeutic applications may derive from the actions of benzodiazepine agonists and inverse agonists on food procurement and ingestion." @default.
- W2015995382 created "2016-06-24" @default.
- W2015995382 creator A5020739932 @default.
- W2015995382 date "2005-04-01" @default.
- W2015995382 modified "2023-09-25" @default.
- W2015995382 title "Palatability-dependent appetite and benzodiazepines: new directions from the pharmacology of GABAA receptor subtypes" @default.
- W2015995382 cites W1548297237 @default.
- W2015995382 cites W1565551672 @default.
- W2015995382 cites W1593014028 @default.
- W2015995382 cites W1802685233 @default.
- W2015995382 cites W1824285989 @default.
- W2015995382 cites W1879000632 @default.
- W2015995382 cites W1963512037 @default.
- W2015995382 cites W1964191104 @default.
- W2015995382 cites W1964198111 @default.
- W2015995382 cites W1964806566 @default.
- W2015995382 cites W1965814070 @default.
- W2015995382 cites W1966101832 @default.
- W2015995382 cites W1966569420 @default.
- W2015995382 cites W1973254116 @default.
- W2015995382 cites W1976769955 @default.
- W2015995382 cites W1978342290 @default.
- W2015995382 cites W1979244909 @default.
- W2015995382 cites W1979367476 @default.
- W2015995382 cites W1980341670 @default.
- W2015995382 cites W1980661175 @default.
- W2015995382 cites W1980755879 @default.
- W2015995382 cites W1980810001 @default.
- W2015995382 cites W1981205771 @default.
- W2015995382 cites W1982904143 @default.
- W2015995382 cites W1983404085 @default.
- W2015995382 cites W1983544988 @default.
- W2015995382 cites W1983621709 @default.
- W2015995382 cites W1984624506 @default.
- W2015995382 cites W1984923982 @default.
- W2015995382 cites W1985277035 @default.
- W2015995382 cites W1985383722 @default.
- W2015995382 cites W1985881933 @default.
- W2015995382 cites W1987534078 @default.
- W2015995382 cites W1988949197 @default.
- W2015995382 cites W1989902100 @default.
- W2015995382 cites W1993462849 @default.
- W2015995382 cites W1993548390 @default.
- W2015995382 cites W1994091958 @default.
- W2015995382 cites W1994448673 @default.
- W2015995382 cites W1995188076 @default.
- W2015995382 cites W1996480937 @default.
- W2015995382 cites W1996580405 @default.
- W2015995382 cites W1997172666 @default.
- W2015995382 cites W1998691527 @default.
- W2015995382 cites W2000120332 @default.
- W2015995382 cites W2000459835 @default.
- W2015995382 cites W2000839039 @default.
- W2015995382 cites W2001303662 @default.
- W2015995382 cites W2001619275 @default.
- W2015995382 cites W2003411269 @default.
- W2015995382 cites W2005146693 @default.
- W2015995382 cites W2008375950 @default.
- W2015995382 cites W2009712351 @default.
- W2015995382 cites W2010237601 @default.
- W2015995382 cites W2010400196 @default.
- W2015995382 cites W2011048427 @default.
- W2015995382 cites W2011899364 @default.
- W2015995382 cites W2012628815 @default.
- W2015995382 cites W2016072491 @default.
- W2015995382 cites W2016431808 @default.
- W2015995382 cites W2017331493 @default.
- W2015995382 cites W2021194790 @default.
- W2015995382 cites W2022170649 @default.
- W2015995382 cites W2022549781 @default.
- W2015995382 cites W2023132644 @default.
- W2015995382 cites W2023732657 @default.
- W2015995382 cites W2025429574 @default.
- W2015995382 cites W2025667815 @default.
- W2015995382 cites W2026798030 @default.
- W2015995382 cites W2026820393 @default.
- W2015995382 cites W2026920124 @default.
- W2015995382 cites W2027958547 @default.
- W2015995382 cites W2029253918 @default.
- W2015995382 cites W2030153935 @default.
- W2015995382 cites W2031759347 @default.
- W2015995382 cites W2033271218 @default.
- W2015995382 cites W2034176474 @default.
- W2015995382 cites W2034181049 @default.
- W2015995382 cites W2036892339 @default.
- W2015995382 cites W2037046144 @default.
- W2015995382 cites W2038203163 @default.
- W2015995382 cites W2039299884 @default.
- W2015995382 cites W2039405031 @default.
- W2015995382 cites W2039884272 @default.
- W2015995382 cites W2040964381 @default.
- W2015995382 cites W2043300507 @default.
- W2015995382 cites W2043900119 @default.
- W2015995382 cites W2044230607 @default.
- W2015995382 cites W2044379852 @default.
- W2015995382 cites W204518945 @default.
- W2015995382 cites W2045591191 @default.
- W2015995382 cites W2046787882 @default.