FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015998085> ?p ?o ?g. }

• W2015998085 endingPage "11" @default.
• W2015998085 startingPage "1" @default.
• W2015998085 abstract "TRIpartite Motif (TRIM) family proteins are ring finger domain-containing, multi-domain proteins implicated in many biological processes. Members of the TRIM-9/C-I subfamily of TRIM proteins, including TRIM-9, MID1 and MID2, have neuronal functions and are associated with neurological diseases. To explore whether the functions of C-I TRIM proteins are conserved in invertebrates, we analyzed Caenorhabditis elegans and Drosophila trim-9 mutants. C. elegans trim-9 mutants exhibit defects in the ventral guidance of hermaphrodite specific neuron (HSN) and the touch neuron AVM. Further genetic analyses indicate that TRIM-9 participates in the UNC-6-UNC-40 attraction pathway. Asymmetric distribution of UNC-40 during HSN development is normal in trim-9 mutants. However, the asymmetric localization of MIG-10, a downstream effector of UNC-40, is abolished in trim-9 mutants. These results suggest that TRIM-9 functions upstream of MIG-10 in the UNC-40 pathway. Moreover, we showed that TRIM-9 exhibits E3 ubiquitin ligase activity in vitro and this activity is important for TRIM-9 function in vivo. Additionally, we found that Drosophila trim-9 is required for the midline attraction of a group of sensory neuron axons. Over-expression of the Netrin/UNC-6 receptor Frazzled suppresses the guidance defects in trim-9 mutants. Our study reveals an evolutionarily conserved function of TRIM-9 in the UNC-40/Frazzled-mediated UNC-6/Netrin attraction pathway." @default.
• W2015998085 created "2016-06-24" @default.
• W2015998085 creator A5041342442 @default.
• W2015998085 creator A5043937349 @default.
• W2015998085 creator A5047598263 @default.
• W2015998085 creator A5070737489 @default.
• W2015998085 creator A5075359444 @default.
• W2015998085 creator A5079738340 @default.
• W2015998085 creator A5084147442 @default.
• W2015998085 creator A5089666742 @default.
• W2015998085 creator A5091105051 @default.
• W2015998085 date "2011-01-01" @default.
• W2015998085 modified "2023-10-07" @default.
• W2015998085 title "TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance" @default.
• W2015998085 cites W1576464279 @default.
• W2015998085 cites W1896069710 @default.
• W2015998085 cites W1944127002 @default.
• W2015998085 cites W1966272997 @default.
• W2015998085 cites W1967734203 @default.
• W2015998085 cites W1975974821 @default.
• W2015998085 cites W1976179891 @default.
• W2015998085 cites W1993490391 @default.
• W2015998085 cites W1999181858 @default.
• W2015998085 cites W2000432680 @default.
• W2015998085 cites W2014519647 @default.
• W2015998085 cites W2017257935 @default.
• W2015998085 cites W2017688356 @default.
• W2015998085 cites W2022376508 @default.
• W2015998085 cites W2023981624 @default.
• W2015998085 cites W2030194551 @default.
• W2015998085 cites W2033712349 @default.
• W2015998085 cites W2035384780 @default.
• W2015998085 cites W2040884996 @default.
• W2015998085 cites W2041306367 @default.
• W2015998085 cites W2043260620 @default.
• W2015998085 cites W2044005732 @default.
• W2015998085 cites W2045528596 @default.
• W2015998085 cites W2053384096 @default.
• W2015998085 cites W2061822901 @default.
• W2015998085 cites W2063962655 @default.
• W2015998085 cites W2068209211 @default.
• W2015998085 cites W2083017377 @default.
• W2015998085 cites W2088895400 @default.
• W2015998085 cites W2089879664 @default.
• W2015998085 cites W2090865074 @default.
• W2015998085 cites W2110520657 @default.
• W2015998085 cites W2111051650 @default.
• W2015998085 cites W2124248841 @default.
• W2015998085 cites W2131037087 @default.
• W2015998085 cites W2132818618 @default.
• W2015998085 cites W2135168051 @default.
• W2015998085 cites W2150409874 @default.
• W2015998085 cites W2155584359 @default.
• W2015998085 cites W2162849876 @default.
• W2015998085 cites W2164494941 @default.
• W2015998085 cites W2164591040 @default.
• W2015998085 cites W2169800968 @default.
• W2015998085 doi "https://doi.org/10.1016/j.jcg.2010.12.004" @default.
• W2015998085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21338947" @default.
• W2015998085 hasPublicationYear "2011" @default.
• W2015998085 type Work @default.
• W2015998085 sameAs 2015998085 @default.
• W2015998085 citedByCount "24" @default.
• W2015998085 countsByYear W20159980852012 @default.
• W2015998085 countsByYear W20159980852013 @default.
• W2015998085 countsByYear W20159980852014 @default.
• W2015998085 countsByYear W20159980852015 @default.
• W2015998085 countsByYear W20159980852016 @default.
• W2015998085 countsByYear W20159980852017 @default.
• W2015998085 countsByYear W20159980852018 @default.
• W2015998085 countsByYear W20159980852021 @default.
• W2015998085 countsByYear W20159980852022 @default.
• W2015998085 crossrefType "journal-article" @default.
• W2015998085 hasAuthorship W2015998085A5041342442 @default.
• W2015998085 hasAuthorship W2015998085A5043937349 @default.
• W2015998085 hasAuthorship W2015998085A5047598263 @default.
• W2015998085 hasAuthorship W2015998085A5070737489 @default.
• W2015998085 hasAuthorship W2015998085A5075359444 @default.
• W2015998085 hasAuthorship W2015998085A5079738340 @default.
• W2015998085 hasAuthorship W2015998085A5084147442 @default.
• W2015998085 hasAuthorship W2015998085A5089666742 @default.
• W2015998085 hasAuthorship W2015998085A5091105051 @default.
• W2015998085 hasConcept C104317684 @default.
• W2015998085 hasConcept C111919701 @default.
• W2015998085 hasConcept C127955056 @default.
• W2015998085 hasConcept C134459356 @default.
• W2015998085 hasConcept C143065580 @default.
• W2015998085 hasConcept C199215989 @default.
• W2015998085 hasConcept C25602115 @default.
• W2015998085 hasConcept C2778944004 @default.
• W2015998085 hasConcept C2779530196 @default.
• W2015998085 hasConcept C2780104201 @default.
• W2015998085 hasConcept C41008148 @default.
• W2015998085 hasConcept C54355233 @default.
• W2015998085 hasConcept C69125201 @default.
• W2015998085 hasConcept C86803240 @default.
• W2015998085 hasConcept C88611116 @default.
• W2015998085 hasConcept C95444343 @default.

• next