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• W2015998692 abstract "This paper concerns the Circular Dichroism (CD) and Nuclear Magnetic Resonance (NMR) structural studies of the quadruple helix arrangements adopted by three tailored oligodeoxyribonucleotide analogues, namely d(TGMeGGT), d(TGGMeGT) and d(TGGGMeT), where dGMe represents a 8-methyl-2′-deoxyguanosine residue. The results of this study clearly demonstrate that the effects of the incorporation of dGMe instead of a dG residue are strongly dependant upon the positioning of a single base replacement along the sequence. As such, d(TGMeGGT), d(TGGMeGT) have been found to form 4-fold symmetric quadruplexes with all strands parallel and equivalent to each other, each more stable than their natural counterpart. NMR experiments clearly indicate that [d(TGMeGGT)]4 possesses a GMe-tetrad with all dGMe residues in a syn-glycosidic conformation while an anti-arrangement is apparent for the four dGMe of [d(TGGMeGT)]4. As the two complexes show a quite different CD behaviour, a possible relationship between the presence of residues adopting syn-glycosidic conformations and CD profiles is briefly discussed. As far as d(TGGGMeT) is concerned, NMR data indicate that at 25°C it exists primarily as a single-strand conformation in equilibrium with minor amounts of a quadruplex structure." @default.
• W2015998692 created "2016-06-24" @default.
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• W2015998692 date "2005-10-24" @default.
• W2015998692 modified "2023-10-16" @default.
• W2015998692 title "8-Methyl-2'-deoxyguanosine incorporation into parallel DNA quadruplex structures" @default.
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• W2015998692 doi "https://doi.org/10.1093/nar/gki924" @default.
• W2015998692 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1275585" @default.
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