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- W2016000897 abstract "Controlling neural stem and progenitor cell (NSPC) proliferation is critical to maintain neurogenesis in the mammalian brain throughout life. However, it remains poorly understood how niche-derived cues such as β1-integrin-mediated signaling are translated into NSPC-intrinsic molecular changes to regulate NSPC activity. Here we show that genetic deletion of integrin-linked kinase ( ILK ) increases NSPC proliferation through PINCH1/2-dependent enhancement of c-Jun N-terminal protein kinase activity in both neurogenic regions of the adult mouse brain. This effect downstream of ILK signaling is mediated through loss of Ras suppressor unit-1 (RSU-1), as virus-based reconstitution of RSU-1 expression rescued the ILK-dependent effects on NSPC proliferation. Thus, we here identified an intracellular signaling cascade linking extrinsic integrin-mediated signaling to NSPC proliferation and characterized a novel mechanism that regulates NSPC activity in the adult mammalian brain." @default.
- W2016000897 created "2016-06-24" @default.
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- W2016000897 date "2014-04-09" @default.
- W2016000897 modified "2023-10-12" @default.
- W2016000897 title "Dissecting Integrin-Dependent Regulation of Neural Stem Cell Proliferation in the Adult Brain" @default.
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- W2016000897 doi "https://doi.org/10.1523/jneurosci.4928-13.2014" @default.
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