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- W2016001804 abstract "An examination was made of several systems in which thiouracil and the pyrimidines, uracil, thymine and orotic acid, might compete. The goitrogenic effects of thiouracil were compared with those of other thiopyrimidines and thiopurines. Only thiopyrimidines exhibited goitrogenic properties with thioorotic acid and thiocytosine being weakly goitrogenic and thiothymine inactive. The goitrogenic properties of thiouracil in an iodine-deficient diet were not reduced by simultaneous administration of daily doses of uracil or thymine 300 and 120 times, respectively, that of thiouracil. The pyrimidines and thiouracil were not degraded to 14CO2 by rat thyroid or calf thymus slices. Rat liver slices rapidly oxidized uracil-2-14C, metabolized orotic acid-6-14C only slightly, and did not appear to degrade thiouracil at all. The addition of thiouracil had no discernible effect on the degradation of uracil. Utilization of uracil for RNA formation by thyroid slices was not altered by the presence of thiouracil but was d..." @default.
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- W2016001804 date "1965-04-01" @default.
- W2016001804 modified "2023-09-27" @default.
- W2016001804 title "Thiouracil-Pyrimidine Relationships in Thyroid and Other Tissues" @default.
- W2016001804 doi "https://doi.org/10.1210/endo-76-4-728" @default.
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