FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016004823> ?p ?o ?g. }

• W2016004823 endingPage "1299" @default.
• W2016004823 startingPage "1297" @default.
• W2016004823 abstract "Recent statistics from the Alzheimer Research Trust suggest that in the UK alone 820 000 people are affected by dementia with a cost to the economy of £23 billion/year. Similar figures apply to all developed countries and most others are catching up rapidly. With increasing life expectancy, age-related dementia is seen globally as an urgent public health priority.Histological examination of the brain is still regarded as the gold standard for diagnosis of the specific disease process underlying dementia, the commonest cause of which is Alzheimer’s disease. The main features of Alzheimer’s disease are extracellular accumulation of amyloid β-protein (Aβ) in the form of plaques and in blood vessel walls as cerebral amyloid angiopathy; intraneuronal accumulation of tau protein forming tangles in neuronal cell bodies as well as in neuronal processes situated close to plaques (dystrophic neurites) and elsewhere (neuropil threads); activation of microglia and astrocytes; and neuronal and synaptic loss. However, histological assessment of the disease has several limitations including, almost by definition, observations made at only one time point in the disease, usually the end-stage of a neurodegenerative process that has been developing over many years. This means that using post-mortem neuropathology, we have little or no notion of the dynamics of the pathological processes involved, how they are interrelated in terms of cause and effect, and which feature, if any, best correlates with, or causes, the cognitive dysfunction.The principal hypothesis for the pathogenesis of Alzheimer’s disease for two decades or more has been built around amyloid, and known as the Aβ cascade hypothesis, which states that Aβ, either in the form of extracellular amyloid plaques or in soluble or oligomeric forms, has the key role in initiation of the disease. A powerful way to test the Aβ hypothesis is to modify this aspect of the pathophysiology …" @default.
• W2016004823 created "2016-06-24" @default.
• W2016004823 creator A5008325892 @default.
• W2016004823 creator A5053163430 @default.
• W2016004823 date "2010-04-23" @default.
• W2016004823 modified "2023-09-27" @default.
• W2016004823 title "Are we getting to grips with Alzheimer's disease at last?" @default.
• W2016004823 cites W1546526125 @default.
• W2016004823 cites W1693283493 @default.
• W2016004823 cites W1823419340 @default.
• W2016004823 cites W1979415323 @default.
• W2016004823 cites W2000917982 @default.
• W2016004823 cites W2024262813 @default.
• W2016004823 cites W2053488262 @default.
• W2016004823 cites W2060851420 @default.
• W2016004823 cites W2088084445 @default.
• W2016004823 cites W2150231759 @default.
• W2016004823 cites W2152446053 @default.
• W2016004823 cites W2157064933 @default.
• W2016004823 doi "https://doi.org/10.1093/brain/awq099" @default.
• W2016004823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20418529" @default.
• W2016004823 hasPublicationYear "2010" @default.
• W2016004823 type Work @default.
• W2016004823 sameAs 2016004823 @default.
• W2016004823 citedByCount "4" @default.
• W2016004823 countsByYear W20160048232013 @default.
• W2016004823 countsByYear W20160048232015 @default.
• W2016004823 countsByYear W20160048232018 @default.
• W2016004823 countsByYear W20160048232019 @default.
• W2016004823 crossrefType "journal-article" @default.
• W2016004823 hasAuthorship W2016004823A5008325892 @default.
• W2016004823 hasAuthorship W2016004823A5053163430 @default.
• W2016004823 hasBestOaLocation W20160048231 @default.
• W2016004823 hasConcept C126322002 @default.
• W2016004823 hasConcept C15744967 @default.
• W2016004823 hasConcept C169760540 @default.
• W2016004823 hasConcept C2779134260 @default.
• W2016004823 hasConcept C502032728 @default.
• W2016004823 hasConcept C71924100 @default.
• W2016004823 hasConceptScore W2016004823C126322002 @default.
• W2016004823 hasConceptScore W2016004823C15744967 @default.
• W2016004823 hasConceptScore W2016004823C169760540 @default.
• W2016004823 hasConceptScore W2016004823C2779134260 @default.
• W2016004823 hasConceptScore W2016004823C502032728 @default.
• W2016004823 hasConceptScore W2016004823C71924100 @default.
• W2016004823 hasIssue "5" @default.
• W2016004823 hasLocation W20160048231 @default.
• W2016004823 hasLocation W20160048232 @default.
• W2016004823 hasOpenAccess W2016004823 @default.
• W2016004823 hasPrimaryLocation W20160048231 @default.
• W2016004823 hasRelatedWork W17728192 @default.
• W2016004823 hasRelatedWork W1963787144 @default.
• W2016004823 hasRelatedWork W1975130127 @default.
• W2016004823 hasRelatedWork W2033160153 @default.
• W2016004823 hasRelatedWork W2106304681 @default.
• W2016004823 hasRelatedWork W2390625150 @default.
• W2016004823 hasRelatedWork W2481229554 @default.
• W2016004823 hasRelatedWork W2525664020 @default.
• W2016004823 hasRelatedWork W2748952813 @default.
• W2016004823 hasRelatedWork W2899084033 @default.
• W2016004823 hasVolume "133" @default.
• W2016004823 isParatext "false" @default.
• W2016004823 isRetracted "false" @default.
• W2016004823 magId "2016004823" @default.
• W2016004823 workType "article" @default.