FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016005125> ?p ?o ?g. }

• W2016005125 endingPage "117" @default.
• W2016005125 startingPage "109" @default.
• W2016005125 abstract "The roots of Achyranthes japonica Nakai have been used in traditional herbal medicine for the treatment of edema and arthritis in Korea.In this study, we investigated the molecular mechanism responsible for anti-inflammatory effects of the aqueous extract of A. japonica roots (AJ) in LPS-stimulated macrophages.Nitric oxide (NO) production and as inducible nitric oxide synthase (iNOS) expression were examined in TG-elicited peritoneal macrophages and RAW 264.7 cells. Cell viability was monitored by MTT assay. Protein and mRNA expressions were determined by Western blotting and RT-PCR, respectively. The activity of NF-κB and Nrf2 were examined by EMSA, immunocytochemistry or reporter assay.AJ inhibited LPS-induced NO secretion as well as iNOS expression, without affecting cell viability. Furthermore, AJ suppressed LPS-induced NF-κB activation, degradation of IκB-α, phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38. Further study demonstrated that AJ induced heme oxygenase-1 (HO-1) gene expression via nuclear translocation and transactivation of Nrf2. In addition, the inhibitory effects of AJ on iNOS expression were abrogated by small interfering RNA-mediated knock-down of HO-1.These results suggest that AJ suppresses LPS-induced NO production and iNOS expression in macrophages through the inhibition of IκB/NF-κB and MAPK as well as the Nrf2-mediated HO-1 induction. These findings provide the scientific rationale for anti-inflammatory therapeutic use of A. japonica roots." @default.
• W2016005125 created "2016-06-24" @default.
• W2016005125 creator A5003200546 @default.
• W2016005125 creator A5007226887 @default.
• W2016005125 creator A5031272480 @default.
• W2016005125 creator A5047602039 @default.
• W2016005125 creator A5050733578 @default.
• W2016005125 creator A5066408904 @default.
• W2016005125 creator A5078809425 @default.
• W2016005125 date "2012-10-01" @default.
• W2016005125 modified "2023-10-18" @default.
• W2016005125 title "Achyranthes japonica exhibits anti-inflammatory effect via NF-κB suppression and HO-1 induction in macrophages" @default.
• W2016005125 cites W1542066254 @default.
• W2016005125 cites W1591881963 @default.
• W2016005125 cites W1600690434 @default.
• W2016005125 cites W1966197860 @default.
• W2016005125 cites W1970993437 @default.
• W2016005125 cites W1991070376 @default.
• W2016005125 cites W1993623548 @default.
• W2016005125 cites W1996521867 @default.
• W2016005125 cites W2000258847 @default.
• W2016005125 cites W2001751920 @default.
• W2016005125 cites W2003011230 @default.
• W2016005125 cites W2003056857 @default.
• W2016005125 cites W2005904261 @default.
• W2016005125 cites W2005990374 @default.
• W2016005125 cites W2007087158 @default.
• W2016005125 cites W2022398608 @default.
• W2016005125 cites W2050283646 @default.
• W2016005125 cites W2055110079 @default.
• W2016005125 cites W2068406884 @default.
• W2016005125 cites W2076530627 @default.
• W2016005125 cites W2087518067 @default.
• W2016005125 cites W2090327604 @default.
• W2016005125 cites W2095294463 @default.
• W2016005125 cites W2097655876 @default.
• W2016005125 cites W2123063562 @default.
• W2016005125 cites W2130074959 @default.
• W2016005125 cites W2144675149 @default.
• W2016005125 cites W2149200346 @default.
• W2016005125 cites W2158359850 @default.
• W2016005125 cites W2163792649 @default.
• W2016005125 cites W2165626477 @default.
• W2016005125 doi "https://doi.org/10.1016/j.jep.2012.08.037" @default.
• W2016005125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22974544" @default.
• W2016005125 hasPublicationYear "2012" @default.
• W2016005125 type Work @default.
• W2016005125 sameAs 2016005125 @default.
• W2016005125 citedByCount "47" @default.
• W2016005125 countsByYear W20160051252013 @default.
• W2016005125 countsByYear W20160051252014 @default.
• W2016005125 countsByYear W20160051252015 @default.
• W2016005125 countsByYear W20160051252016 @default.
• W2016005125 countsByYear W20160051252017 @default.
• W2016005125 countsByYear W20160051252018 @default.
• W2016005125 countsByYear W20160051252019 @default.
• W2016005125 countsByYear W20160051252020 @default.
• W2016005125 countsByYear W20160051252021 @default.
• W2016005125 countsByYear W20160051252022 @default.
• W2016005125 countsByYear W20160051252023 @default.
• W2016005125 crossrefType "journal-article" @default.
• W2016005125 hasAuthorship W2016005125A5003200546 @default.
• W2016005125 hasAuthorship W2016005125A5007226887 @default.
• W2016005125 hasAuthorship W2016005125A5031272480 @default.
• W2016005125 hasAuthorship W2016005125A5047602039 @default.
• W2016005125 hasAuthorship W2016005125A5050733578 @default.
• W2016005125 hasAuthorship W2016005125A5066408904 @default.
• W2016005125 hasAuthorship W2016005125A5078809425 @default.
• W2016005125 hasConcept C104317684 @default.
• W2016005125 hasConcept C134018914 @default.
• W2016005125 hasConcept C1491633281 @default.
• W2016005125 hasConcept C153911025 @default.
• W2016005125 hasConcept C181199279 @default.
• W2016005125 hasConcept C184235292 @default.
• W2016005125 hasConcept C185592680 @default.
• W2016005125 hasConcept C22615655 @default.
• W2016005125 hasConcept C2776217839 @default.
• W2016005125 hasConcept C2777622882 @default.
• W2016005125 hasConcept C2777730290 @default.
• W2016005125 hasConcept C2779219270 @default.
• W2016005125 hasConcept C2779730028 @default.
• W2016005125 hasConcept C2780783641 @default.
• W2016005125 hasConcept C51551487 @default.
• W2016005125 hasConcept C519581460 @default.
• W2016005125 hasConcept C53227056 @default.
• W2016005125 hasConcept C54009773 @default.
• W2016005125 hasConcept C55493867 @default.
• W2016005125 hasConcept C57074206 @default.
• W2016005125 hasConcept C62112901 @default.
• W2016005125 hasConcept C62478195 @default.
• W2016005125 hasConcept C86803240 @default.
• W2016005125 hasConceptScore W2016005125C104317684 @default.
• W2016005125 hasConceptScore W2016005125C134018914 @default.
• W2016005125 hasConceptScore W2016005125C1491633281 @default.
• W2016005125 hasConceptScore W2016005125C153911025 @default.
• W2016005125 hasConceptScore W2016005125C181199279 @default.
• W2016005125 hasConceptScore W2016005125C184235292 @default.
• W2016005125 hasConceptScore W2016005125C185592680 @default.

• next