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• W2016006138 abstract "Rainbow trout, yellow perch, carp, bluegill, largemouth bass, and bullhead were treated with graded doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 1, 5, 25, or 125 μg/kg) or vehicle, ip. The lethal potency of TCDD tended to be greater in yellow perch, carp, and bullhead than in the other three species (LD50 80 days post-treatment, 3–5 versus 10–16 μg/kg, respectively). All species treated with the highest dose of TCDD (125 μg/kg) displayed a latency period of 1–4 weeks prior to death; longer latency periods were produced by lower lethal doses. Effects of TCDD treatment on body weight were both species-dependent and dose-dependent. Fin necrosis was observed in all fish species; however, cutaneous hemorrhage was observed only in TCDD-treated perch, carp, and bluegill, and cutaneous hyperpigmentation only in TCDD-treated carp and largemouth bass. Gallbladder bile was analyzed for TCDD and its metabolites 7 days after fish were injected with [14C]TCDD (60 μg/kg, ip). At least three TCDD metabolites in addition to the parent compound were found in the gallbladder bile of all six species. In addition, the retention time of the major biliary TCDD metabolite (determined by HPLC) was similar in all species except yellow perch. β-Glucuronidase treatment of the bile from large-mouth bass and bluegill suggested that at least two of the TCDD metabolites were glucuronide conjugates. Thus, species differences exist in the lethal potency, signs of overt toxicity, and biotransformation of TCDD among freshwater fish." @default.
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• W2016006138 date "1988-02-01" @default.
• W2016006138 modified "2023-09-27" @default.
• W2016006138 title "Species differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and biotransformation in fish*1" @default.
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• W2016006138 doi "https://doi.org/10.1016/0272-0590(88)90304-1" @default.
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