FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016010116> ?p ?o ?g. }

• W2016010116 endingPage "e66842" @default.
• W2016010116 startingPage "e66842" @default.
• W2016010116 abstract "Background The recurrence of colorectal cancer (CRC) is frequent within the first year of curative resection surgery and may be unavoidable. microRNAs have been suggested to play roles in carcinogenesis and cancer recurrence. We recently identified microRNA-29c (miRNA-29c) as a predictor of early recurrence in CRC. In the present study, we further investigated the functions and serum level of miRNA-29c in relation to early recurrence of CRC. Methods First we further confirmed overexpression of miRNA-29c in non-early relapse subjects. Gain-of-function in vitro studies were used to evaluate the effect of miRNA-29c on cell proliferation, migration, invasion, and cell cycle progression. The colon cancer cell line Caco2 and a stable clone overexpressing miRNA-29c were xenografted to evaluate the in vivo effect of miRNA-29c in null mice. Finally, circulating miRNA-29c was investigated as a potential biomarker for identifying early relapse. Results miRNA-29c expression significantly decreased during early relapse compared to non-early relapse in UICC stage II and III CRC patients (P = 0.021). In vitro studies showed that overexpression of miRNA-29c inhibited cell proliferation and migration. The cell cycle studies also revealed that miRNA-29c caused an accumulation of the G1 and G2 population. In vivo, miRNA-29c suppressed tumor growth in null mice. The serum miRNA-29c increased significantly in early relapsed patients compared to non-early elapsed patients (P = 0.012). Conclusions miRNA-29c shows anti-tumorigenesis activity, and preoperative circulating miRNA-29c levels can be used to predict postoperative early relapse of CRC." @default.
• W2016010116 created "2016-06-24" @default.
• W2016010116 creator A5006129657 @default.
• W2016010116 creator A5008262587 @default.
• W2016010116 creator A5020485663 @default.
• W2016010116 creator A5024524978 @default.
• W2016010116 creator A5040749080 @default.
• W2016010116 creator A5053604127 @default.
• W2016010116 creator A5090739321 @default.
• W2016010116 date "2013-06-28" @default.
• W2016010116 modified "2023-10-06" @default.
• W2016010116 title "The Functional Significance of MicroRNA-29c in Patients with Colorectal Cancer: A Potential Circulating Biomarker for Predicting Early Relapse" @default.
• W2016010116 cites W1499305226 @default.
• W2016010116 cites W1563316806 @default.
• W2016010116 cites W1963691340 @default.
• W2016010116 cites W1986332208 @default.
• W2016010116 cites W1998009232 @default.
• W2016010116 cites W2005873549 @default.
• W2016010116 cites W2006797972 @default.
• W2016010116 cites W2012536934 @default.
• W2016010116 cites W2013269714 @default.
• W2016010116 cites W2015097233 @default.
• W2016010116 cites W2035213975 @default.
• W2016010116 cites W2039023109 @default.
• W2016010116 cites W2042907812 @default.
• W2016010116 cites W2061873339 @default.
• W2016010116 cites W2066344609 @default.
• W2016010116 cites W2066442082 @default.
• W2016010116 cites W2072688209 @default.
• W2016010116 cites W2097180978 @default.
• W2016010116 cites W2101383571 @default.
• W2016010116 cites W2103177465 @default.
• W2016010116 cites W2113239055 @default.
• W2016010116 cites W2113551318 @default.
• W2016010116 cites W2115093090 @default.
• W2016010116 cites W2123680132 @default.
• W2016010116 cites W2135836598 @default.
• W2016010116 cites W2139528114 @default.
• W2016010116 cites W2140245250 @default.
• W2016010116 cites W2146684369 @default.
• W2016010116 cites W2146857332 @default.
• W2016010116 cites W2147319300 @default.
• W2016010116 doi "https://doi.org/10.1371/journal.pone.0066842" @default.
• W2016010116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3696003" @default.
• W2016010116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23840538" @default.
• W2016010116 hasPublicationYear "2013" @default.
• W2016010116 type Work @default.
• W2016010116 sameAs 2016010116 @default.
• W2016010116 citedByCount "41" @default.
• W2016010116 countsByYear W20160101162014 @default.
• W2016010116 countsByYear W20160101162015 @default.
• W2016010116 countsByYear W20160101162016 @default.
• W2016010116 countsByYear W20160101162017 @default.
• W2016010116 countsByYear W20160101162018 @default.
• W2016010116 countsByYear W20160101162019 @default.
• W2016010116 countsByYear W20160101162020 @default.
• W2016010116 countsByYear W20160101162021 @default.
• W2016010116 countsByYear W20160101162022 @default.
• W2016010116 countsByYear W20160101162023 @default.
• W2016010116 crossrefType "journal-article" @default.
• W2016010116 hasAuthorship W2016010116A5006129657 @default.
• W2016010116 hasAuthorship W2016010116A5008262587 @default.
• W2016010116 hasAuthorship W2016010116A5020485663 @default.
• W2016010116 hasAuthorship W2016010116A5024524978 @default.
• W2016010116 hasAuthorship W2016010116A5040749080 @default.
• W2016010116 hasAuthorship W2016010116A5053604127 @default.
• W2016010116 hasAuthorship W2016010116A5090739321 @default.
• W2016010116 hasBestOaLocation W20160101161 @default.
• W2016010116 hasConcept C104317684 @default.
• W2016010116 hasConcept C121608353 @default.
• W2016010116 hasConcept C126322002 @default.
• W2016010116 hasConcept C143998085 @default.
• W2016010116 hasConcept C145059251 @default.
• W2016010116 hasConcept C207001950 @default.
• W2016010116 hasConcept C2781197716 @default.
• W2016010116 hasConcept C2908647359 @default.
• W2016010116 hasConcept C29537977 @default.
• W2016010116 hasConcept C502942594 @default.
• W2016010116 hasConcept C526805850 @default.
• W2016010116 hasConcept C54355233 @default.
• W2016010116 hasConcept C555283112 @default.
• W2016010116 hasConcept C62112901 @default.
• W2016010116 hasConcept C71924100 @default.
• W2016010116 hasConcept C86803240 @default.
• W2016010116 hasConcept C99454951 @default.
• W2016010116 hasConceptScore W2016010116C104317684 @default.
• W2016010116 hasConceptScore W2016010116C121608353 @default.
• W2016010116 hasConceptScore W2016010116C126322002 @default.
• W2016010116 hasConceptScore W2016010116C143998085 @default.
• W2016010116 hasConceptScore W2016010116C145059251 @default.
• W2016010116 hasConceptScore W2016010116C207001950 @default.
• W2016010116 hasConceptScore W2016010116C2781197716 @default.
• W2016010116 hasConceptScore W2016010116C2908647359 @default.
• W2016010116 hasConceptScore W2016010116C29537977 @default.
• W2016010116 hasConceptScore W2016010116C502942594 @default.
• W2016010116 hasConceptScore W2016010116C526805850 @default.
• W2016010116 hasConceptScore W2016010116C54355233 @default.
• W2016010116 hasConceptScore W2016010116C555283112 @default.

• next