FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016011302> ?p ?o ?g. }

• W2016011302 endingPage "874" @default.
• W2016011302 startingPage "867" @default.
• W2016011302 abstract "Background Research on mesenchymal stromal cells has created high expectations for a variety of therapeutic applications. Extensive propagation to yield enough mesenchymal stromal cells for therapy may result in replicative senescence and thus hamper long-term functionality in vivo. Highly variable proliferation rates of mesenchymal stromal cells in the course of long-term expansions under varying culture conditions may already indicate different propensity for cellular senescence. We hypothesized that senescence-associated regulated genes differ in mesenchymal stromal cells propagated under different culture conditions.Design and Methods Human bone marrow-derived mesenchymal stromal cells were cultured either by serial passaging or by a two-step protocol in three different growth conditions. Culture media were supplemented with either fetal bovine serum in varying concentrations or pooled human platelet lysate.Results All mesenchymal stromal cell preparations revealed significant gene expression changes upon long-term culture. Especially genes involved in cell differentiation, apoptosis and cell death were up-regulated, whereas genes involved in mitosis and proliferation were down-regulated. Furthermore, overlapping senescence-associated gene expression changes were found in all mesenchymal stromal cell preparations.Conclusions Long-term cell growth induced similar gene expression changes in mesenchymal stromal cells independently of isolation and expansion conditions. In advance of therapeutic application, this panel of genes might offer a feasible approach to assessing mesenchymal stromal cell quality with regard to the state of replicative senescence." @default.
• W2016011302 created "2016-06-24" @default.
• W2016011302 creator A5015144738 @default.
• W2016011302 creator A5020525710 @default.
• W2016011302 creator A5024617009 @default.
• W2016011302 creator A5026397452 @default.
• W2016011302 creator A5029625483 @default.
• W2016011302 creator A5029804926 @default.
• W2016011302 creator A5035554715 @default.
• W2016011302 creator A5039359688 @default.
• W2016011302 creator A5054997757 @default.
• W2016011302 creator A5067574718 @default.
• W2016011302 creator A5078729702 @default.
• W2016011302 date "2010-01-06" @default.
• W2016011302 modified "2023-10-15" @default.
• W2016011302 title "Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions" @default.
• W2016011302 cites W1534731743 @default.
• W2016011302 cites W1567481505 @default.
• W2016011302 cites W1804670053 @default.
• W2016011302 cites W1965241231 @default.
• W2016011302 cites W1965426918 @default.
• W2016011302 cites W1970590929 @default.
• W2016011302 cites W1971603822 @default.
• W2016011302 cites W1984180661 @default.
• W2016011302 cites W1993723077 @default.
• W2016011302 cites W1998461585 @default.
• W2016011302 cites W2004314923 @default.
• W2016011302 cites W2010118713 @default.
• W2016011302 cites W2011482325 @default.
• W2016011302 cites W2014698810 @default.
• W2016011302 cites W2025371271 @default.
• W2016011302 cites W2026429432 @default.
• W2016011302 cites W2027716220 @default.
• W2016011302 cites W2030652100 @default.
• W2016011302 cites W2034924908 @default.
• W2016011302 cites W2035176325 @default.
• W2016011302 cites W2036385196 @default.
• W2016011302 cites W2037378549 @default.
• W2016011302 cites W2049446122 @default.
• W2016011302 cites W2049979669 @default.
• W2016011302 cites W2053976497 @default.
• W2016011302 cites W2054375726 @default.
• W2016011302 cites W2055670245 @default.
• W2016011302 cites W2056510698 @default.
• W2016011302 cites W2059539380 @default.
• W2016011302 cites W2059880083 @default.
• W2016011302 cites W2066940076 @default.
• W2016011302 cites W2067028061 @default.
• W2016011302 cites W2080416062 @default.
• W2016011302 cites W2090548715 @default.
• W2016011302 cites W2093242556 @default.
• W2016011302 cites W2099764429 @default.
• W2016011302 cites W2112059462 @default.
• W2016011302 cites W2113619226 @default.
• W2016011302 cites W2120865735 @default.
• W2016011302 cites W2127443288 @default.
• W2016011302 cites W2129298171 @default.
• W2016011302 cites W2130410032 @default.
• W2016011302 cites W2138474497 @default.
• W2016011302 cites W2138946470 @default.
• W2016011302 cites W2141917582 @default.
• W2016011302 cites W2142186203 @default.
• W2016011302 cites W2150110701 @default.
• W2016011302 cites W2155852899 @default.
• W2016011302 cites W2156815362 @default.
• W2016011302 cites W2157795344 @default.
• W2016011302 cites W2159596235 @default.
• W2016011302 cites W2168766237 @default.
• W2016011302 cites W2398842251 @default.
• W2016011302 cites W45534775 @default.
• W2016011302 doi "https://doi.org/10.3324/haematol.2009.011692" @default.
• W2016011302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2878782" @default.
• W2016011302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20053868" @default.
• W2016011302 hasPublicationYear "2010" @default.
• W2016011302 type Work @default.
• W2016011302 sameAs 2016011302 @default.
• W2016011302 citedByCount "103" @default.
• W2016011302 countsByYear W20160113022012 @default.
• W2016011302 countsByYear W20160113022013 @default.
• W2016011302 countsByYear W20160113022014 @default.
• W2016011302 countsByYear W20160113022015 @default.
• W2016011302 countsByYear W20160113022016 @default.
• W2016011302 countsByYear W20160113022017 @default.
• W2016011302 countsByYear W20160113022018 @default.
• W2016011302 countsByYear W20160113022019 @default.
• W2016011302 countsByYear W20160113022020 @default.
• W2016011302 countsByYear W20160113022021 @default.
• W2016011302 countsByYear W20160113022022 @default.
• W2016011302 countsByYear W20160113022023 @default.
• W2016011302 crossrefType "journal-article" @default.
• W2016011302 hasAuthorship W2016011302A5015144738 @default.
• W2016011302 hasAuthorship W2016011302A5020525710 @default.
• W2016011302 hasAuthorship W2016011302A5024617009 @default.
• W2016011302 hasAuthorship W2016011302A5026397452 @default.
• W2016011302 hasAuthorship W2016011302A5029625483 @default.
• W2016011302 hasAuthorship W2016011302A5029804926 @default.
• W2016011302 hasAuthorship W2016011302A5035554715 @default.
• W2016011302 hasAuthorship W2016011302A5039359688 @default.

• next