FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016014948> ?p ?o ?g. }

• W2016014948 endingPage "352" @default.
• W2016014948 startingPage "345" @default.
• W2016014948 abstract "Nitric oxide (NO) and its reactant product, peroxynitrite, have been implied to mediate neuronal damage following cerebral ischemia. However, the cellular targets of these compounds remain unclear. Studies using poly(ADP-ribose) polymerase (PARP) inhibitors and PARP knock-out mice have recently demonstrated that excessive activation of this nuclear enzyme plays an important role in NO-induced neurotoxicity. To evaluate the relevance of this plausible candidate gene to human stroke, we undertook a case-control study in Japanese. Participants comprised 213 cerebral infarction cases and 374 age- and sex-matched controls. As a primary investigation, we screened polymorphic sites of the PARP gene, and newly identified a total of four polymorphisms in 1230-bp 5'-flanking sequence. None of them were, however, located on the known promoter components of the gene. Two bi-allelic polymorphisms selected and a CA-repeat polymorphism were subsequently characterized in the case-control study, but none were significantly associated with cerebral infarction in the present study. Our data thus suggest that the tested PARP polymorphisms do not principally contribute to cerebral infarction, although extensive searches would be required to clarify whether the PARP gene plays an important role in the pathogenesis of human stroke." @default.
• W2016014948 created "2016-06-24" @default.
• W2016014948 creator A5004675540 @default.
• W2016014948 creator A5040049943 @default.
• W2016014948 creator A5046013878 @default.
• W2016014948 creator A5048858084 @default.
• W2016014948 creator A5050160011 @default.
• W2016014948 creator A5053851057 @default.
• W2016014948 creator A5062468701 @default.
• W2016014948 creator A5064335808 @default.
• W2016014948 creator A5065724424 @default.
• W2016014948 date "2000-02-01" @default.
• W2016014948 modified "2023-10-18" @default.
• W2016014948 title "Evaluation of the poly(ADP-ribose) polymerase gene in human stroke" @default.
• W2016014948 cites W1969652691 @default.
• W2016014948 cites W1971735577 @default.
• W2016014948 cites W1973582222 @default.
• W2016014948 cites W1978000569 @default.
• W2016014948 cites W1988092942 @default.
• W2016014948 cites W2005706069 @default.
• W2016014948 cites W2012874800 @default.
• W2016014948 cites W2024862570 @default.
• W2016014948 cites W2024876727 @default.
• W2016014948 cites W2024884429 @default.
• W2016014948 cites W2025538133 @default.
• W2016014948 cites W2029348404 @default.
• W2016014948 cites W2035064373 @default.
• W2016014948 cites W2035278369 @default.
• W2016014948 cites W2037763236 @default.
• W2016014948 cites W2050388132 @default.
• W2016014948 cites W2054248299 @default.
• W2016014948 cites W2059640915 @default.
• W2016014948 cites W2061442540 @default.
• W2016014948 cites W2069179994 @default.
• W2016014948 cites W2074187719 @default.
• W2016014948 cites W2078764065 @default.
• W2016014948 cites W2085459880 @default.
• W2016014948 cites W2090405981 @default.
• W2016014948 cites W2097276579 @default.
• W2016014948 cites W2114814128 @default.
• W2016014948 cites W2125283476 @default.
• W2016014948 cites W2127445773 @default.
• W2016014948 cites W2129292973 @default.
• W2016014948 cites W2135849441 @default.
• W2016014948 cites W2146141975 @default.
• W2016014948 cites W2160209091 @default.
• W2016014948 cites W2164548131 @default.
• W2016014948 cites W2276478926 @default.
• W2016014948 cites W96819370 @default.
• W2016014948 doi "https://doi.org/10.1016/s0021-9150(99)00284-1" @default.
• W2016014948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10657571" @default.
• W2016014948 hasPublicationYear "2000" @default.
• W2016014948 type Work @default.
• W2016014948 sameAs 2016014948 @default.
• W2016014948 citedByCount "15" @default.
• W2016014948 countsByYear W20160149482013 @default.
• W2016014948 countsByYear W20160149482014 @default.
• W2016014948 countsByYear W20160149482016 @default.
• W2016014948 countsByYear W20160149482022 @default.
• W2016014948 crossrefType "journal-article" @default.
• W2016014948 hasAuthorship W2016014948A5004675540 @default.
• W2016014948 hasAuthorship W2016014948A5040049943 @default.
• W2016014948 hasAuthorship W2016014948A5046013878 @default.
• W2016014948 hasAuthorship W2016014948A5048858084 @default.
• W2016014948 hasAuthorship W2016014948A5050160011 @default.
• W2016014948 hasAuthorship W2016014948A5053851057 @default.
• W2016014948 hasAuthorship W2016014948A5062468701 @default.
• W2016014948 hasAuthorship W2016014948A5064335808 @default.
• W2016014948 hasAuthorship W2016014948A5065724424 @default.
• W2016014948 hasConcept C104317684 @default.
• W2016014948 hasConcept C126322002 @default.
• W2016014948 hasConcept C127413603 @default.
• W2016014948 hasConcept C180754005 @default.
• W2016014948 hasConcept C181199279 @default.
• W2016014948 hasConcept C182979987 @default.
• W2016014948 hasConcept C203014093 @default.
• W2016014948 hasConcept C2778784160 @default.
• W2016014948 hasConcept C2779491297 @default.
• W2016014948 hasConcept C2780645631 @default.
• W2016014948 hasConcept C2780795997 @default.
• W2016014948 hasConcept C2780942790 @default.
• W2016014948 hasConcept C29730261 @default.
• W2016014948 hasConcept C541997718 @default.
• W2016014948 hasConcept C54355233 @default.
• W2016014948 hasConcept C55493867 @default.
• W2016014948 hasConcept C71924100 @default.
• W2016014948 hasConcept C78519656 @default.
• W2016014948 hasConcept C82381507 @default.
• W2016014948 hasConcept C86803240 @default.
• W2016014948 hasConceptScore W2016014948C104317684 @default.
• W2016014948 hasConceptScore W2016014948C126322002 @default.
• W2016014948 hasConceptScore W2016014948C127413603 @default.
• W2016014948 hasConceptScore W2016014948C180754005 @default.
• W2016014948 hasConceptScore W2016014948C181199279 @default.
• W2016014948 hasConceptScore W2016014948C182979987 @default.
• W2016014948 hasConceptScore W2016014948C203014093 @default.
• W2016014948 hasConceptScore W2016014948C2778784160 @default.
• W2016014948 hasConceptScore W2016014948C2779491297 @default.

• next