FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016015838> ?p ?o ?g. }

• W2016015838 endingPage "1580" @default.
• W2016015838 startingPage "1573" @default.
• W2016015838 abstract "In isolated human trophoblastic cells, dopamine (DA) significantly inhibited the angiotensin-II (AII)-stimulated inositol phosphate (IP) accumulation by 44 +/- 8% (EC50, 0.5 +/- 0.2 microM) and human placental lactogen (hPL) release by 85 +/- 5% (EC50, 1.0 +/- 0.8 microM). These effects were blocked by sulpiride, a specific D2 antagonist. On the contrary, scherring 23390 (a specific D1 antagonist) and propranolol (a specific beta-adrenergic antagonist) were ineffective, suggesting that these DA effects are mediated through a DA receptor of the D2 subtype. The mechanism by which DA inhibited AII-stimulated inositol phosphate production implicates a GTP-binding protein sensitive to the islet-activating-protein (IAP), since DA's effects on IP accumulation and hPL release were blocked by this toxin. To further characterize this GTP-binding protein, particulate fractions of placental cells were incubated with [alpha-32P]NAD and IAP. Solubilized extracts were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Two proteins of 40 and 41 kDa mol wt were specifically ADP ribosylated. They were probably involved in the DA inhibitory processes, since IAP treatment, known to suppress the effects of DA, also reduced the labeling of these two molecules by around 40%. The effects of AII and DA on hPL release appear to be insensitive to the external calcium concentration, since the results were not significantly different in normal (1.8 mM Ca2+) and low Ca2+ (10(-5) M Ca2+) concentrations. On the other hand, increasing the intracellular concentration of cAMP by adding forskolin did not modify the effect of DA on either IP accumulation or hPL release, suggesting that cAMP is not implicated in hPL release from freshly isolated human trophoblastic cells." @default.
• W2016015838 created "2016-06-24" @default.
• W2016015838 creator A5012572436 @default.
• W2016015838 creator A5023885518 @default.
• W2016015838 creator A5025932075 @default.
• W2016015838 creator A5032143796 @default.
• W2016015838 creator A5044684532 @default.
• W2016015838 creator A5056803967 @default.
• W2016015838 creator A5065132245 @default.
• W2016015838 creator A5091477954 @default.
• W2016015838 date "1990-12-01" @default.
• W2016015838 modified "2023-10-17" @default.
• W2016015838 title "An Islet-Activating Protein-Sensitive G-Protein Is Involved in Dopamine Inhibition of Both Angiotensin-Stimulated Inositol Phosphate Production and Human Placental Lactogen Release in Human Trophoblastic Cells*" @default.
• W2016015838 cites W1485683585 @default.
• W2016015838 cites W1498016650 @default.
• W2016015838 cites W1510793262 @default.
• W2016015838 cites W1545308620 @default.
• W2016015838 cites W1557400609 @default.
• W2016015838 cites W1579126107 @default.
• W2016015838 cites W1596993584 @default.
• W2016015838 cites W1790472336 @default.
• W2016015838 cites W1802980406 @default.
• W2016015838 cites W1963977413 @default.
• W2016015838 cites W1988433268 @default.
• W2016015838 cites W2005385083 @default.
• W2016015838 cites W2009463275 @default.
• W2016015838 cites W2013300560 @default.
• W2016015838 cites W2015941240 @default.
• W2016015838 cites W2018176091 @default.
• W2016015838 cites W2025881104 @default.
• W2016015838 cites W2028477931 @default.
• W2016015838 cites W2028999825 @default.
• W2016015838 cites W2032036679 @default.
• W2016015838 cites W2041845093 @default.
• W2016015838 cites W2042746171 @default.
• W2016015838 cites W2043652163 @default.
• W2016015838 cites W2054533778 @default.
• W2016015838 cites W2054736244 @default.
• W2016015838 cites W2058891878 @default.
• W2016015838 cites W2062291911 @default.
• W2016015838 cites W2069635660 @default.
• W2016015838 cites W2071578692 @default.
• W2016015838 cites W207929025 @default.
• W2016015838 cites W2117026099 @default.
• W2016015838 cites W2169503005 @default.
• W2016015838 cites W2224206397 @default.
• W2016015838 cites W2412964675 @default.
• W2016015838 cites W2433870271 @default.
• W2016015838 doi "https://doi.org/10.1210/jcem-71-6-1573" @default.
• W2016015838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2172281" @default.
• W2016015838 hasPublicationYear "1990" @default.
• W2016015838 type Work @default.
• W2016015838 sameAs 2016015838 @default.
• W2016015838 citedByCount "22" @default.
• W2016015838 countsByYear W20160158382015 @default.
• W2016015838 countsByYear W20160158382017 @default.
• W2016015838 crossrefType "journal-article" @default.
• W2016015838 hasAuthorship W2016015838A5012572436 @default.
• W2016015838 hasAuthorship W2016015838A5023885518 @default.
• W2016015838 hasAuthorship W2016015838A5025932075 @default.
• W2016015838 hasAuthorship W2016015838A5032143796 @default.
• W2016015838 hasAuthorship W2016015838A5044684532 @default.
• W2016015838 hasAuthorship W2016015838A5056803967 @default.
• W2016015838 hasAuthorship W2016015838A5065132245 @default.
• W2016015838 hasAuthorship W2016015838A5091477954 @default.
• W2016015838 hasConcept C126322002 @default.
• W2016015838 hasConcept C134018914 @default.
• W2016015838 hasConcept C170493617 @default.
• W2016015838 hasConcept C185592680 @default.
• W2016015838 hasConcept C24998067 @default.
• W2016015838 hasConcept C2777427919 @default.
• W2016015838 hasConcept C2778618036 @default.
• W2016015838 hasConcept C2779276759 @default.
• W2016015838 hasConcept C2908929049 @default.
• W2016015838 hasConcept C49773422 @default.
• W2016015838 hasConcept C71924100 @default.
• W2016015838 hasConcept C80631254 @default.
• W2016015838 hasConcept C84393581 @default.
• W2016015838 hasConcept C86803240 @default.
• W2016015838 hasConceptScore W2016015838C126322002 @default.
• W2016015838 hasConceptScore W2016015838C134018914 @default.
• W2016015838 hasConceptScore W2016015838C170493617 @default.
• W2016015838 hasConceptScore W2016015838C185592680 @default.
• W2016015838 hasConceptScore W2016015838C24998067 @default.
• W2016015838 hasConceptScore W2016015838C2777427919 @default.
• W2016015838 hasConceptScore W2016015838C2778618036 @default.
• W2016015838 hasConceptScore W2016015838C2779276759 @default.
• W2016015838 hasConceptScore W2016015838C2908929049 @default.
• W2016015838 hasConceptScore W2016015838C49773422 @default.
• W2016015838 hasConceptScore W2016015838C71924100 @default.
• W2016015838 hasConceptScore W2016015838C80631254 @default.
• W2016015838 hasConceptScore W2016015838C84393581 @default.
• W2016015838 hasConceptScore W2016015838C86803240 @default.
• W2016015838 hasIssue "6" @default.
• W2016015838 hasLocation W20160158381 @default.
• W2016015838 hasLocation W20160158382 @default.
• W2016015838 hasOpenAccess W2016015838 @default.
• W2016015838 hasPrimaryLocation W20160158381 @default.

• next