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- W2016017183 abstract "In October 1995, a pill scare developed in Europe. In the Netherlands, the recommendations given were 1) to not alarm women without risk for deep vein thrombosis (DVT), and 2) to be reserved in prescribing third generation oral contraceptives (OC) for young women who were beginning OC use. To determine whether there is a change in the prescription of third generation OC after the latest pill scare, prescription data from 1/10/94 to 1/10/96, covering a population of +/- 120,000 persons, were studied with respect to OC use before and after the pill scare. Trend analyses revealed a significant decline in third generation compared with total OC prescribing only in the youngest age category (p = 0.0034). Further, switch behavior was studied. Switches from third to second generation OC were more prevalent after the pill scare than before (odds ratio = 2.63; 95% confidence interval 1.84-3.75) and switches from second to third generation OC were significantly less prevalent after the pill scare. This indicates that Dutch prescribers have reacted to the pill scare in the way that the government recommended.In response to studies demonstrating a moderately increased risk of deep vein thrombosis in users of third-generation oral contraceptives (OCs) with pre-existing risk factors for this condition, the UK Committee on Safety of Medicines issued a statement in October 1995 urging providers to advise OC acceptors of this finding. While some European countries imposed strict limits on the use of third-generation OCs, others decided to await publication of the OC studies. The present study assessed the impact of the pill scare on OC use in the Netherlands, where the recommendations were 1) not to alarm women without risk of deep vein thrombosis and 2) to be conservative in prescribing third-generation OCs for young women initiating OC use. Trend analyses were conducted of prescription data from 12 pharmacies in the northeastern part of the Netherlands covering the period from January 1, 1994, to January 10, 1996. A significant decline in third-generation compared with total OC prescribing was found during the study period only in the youngest age group (under 20 years). After the pill scare, the incidence rate of switches from second- to third-generation OCs compared with switches from one second-generation OC to another was less than before (odds ratio (OR), 0.50; 95% confidence interval (CI), 0.36-0.70). Compared with switches from one third-generation OC to another, switches from a third- to a second-generation OC increased (OR, 2.63; 95% CI, 1.84-3.75). These findings indicate that the 1995 pill scare had resulted in slight changes in Oc use that are consistent with recommendations issued by Dutch health authorities." @default.
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- W2016017183 title "Oral contraceptive use before and after the latest pill scare in the Netherlands" @default.
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- W2016017183 doi "https://doi.org/10.1016/s0010-7824(98)00021-3" @default.
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